DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and Atp8b4

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_038962769.1	Gene:	Atp8b4 / 311396	RGDID:	1306712	Length:	1194	Species:	Rattus norvegicus

Alignment Length:	1356	Identity:	412/1356 - (30%)
Similarity:	653/1356 - (48%)	Gaps:	305/1356 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 KTPKRDH-PNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVA 302
            |...||: ...|:..|:|.|:||.:|:|:|.||.|||.||||.||:|:::|..:||||:......
  Rat    17 KANDRDYNEKFQYADNRIHTSKYNILTFLPINLFEQFQRVANAYFLFLLILQLIPEISSLTWFTT 81

  Fly   303 MIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGDIVHLSNNET 367
            ::|::.|:.:|||||..:|..|..||.::||....|.  ...:.:..||..::||||:.|.||:.
  Rat    82 IVPLVLVISMTAVKDATDDFFRHKSDNQVNNRQSEVL--INSKLQNEKWMNVKVGDIIKLENNQF 144

  Fly   368 VPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEM-QSIFVPSKFVSRVEADAPTTKL 431
            |.||:|||.:|:|.|:||::|.:||||||||.|:.:....|: ..|...:||...|..:||..||
  Rat   145 VAADLLLLSSSEPHGLCYVETAELDGETNLKVRQALPVTSELGADISSLAKFDGIVICEAPNNKL 209

  Fly   432 YRFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQ 496
            .||.|.|.....:.. :|.:.::||...|:||.:..|:|::||.:||.|.|:...::||:.:::.
  Rat   210 DRFSGVLSWKDSKHT-LSNQKIILRGCVLRNTSWCFGMVLFAGPDTKLMQNSGKTKFKRTSIDRL 273

  Fly   497 MNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFPVPYLPPNKLTANMESMW-------------I 548
            ||..|:|....|:.|.::.|:|..:|.|..         .|:...::  .|             .
  Rat   274 MNTLVLWIFGFLVCLGIILAVGNSIWESEV---------GNQFRTSL--FWREGEKSSLFSGFLT 327

  Fly   549 FWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFT 613
            ||:|::||..::|:||||::|:.::...:.|:.:..::.|......|.|...:.||||||::||:
  Rat   328 FWSYVIILNTLVPISLYVSVEVIRLGHSYFINWDRKMYYAAKAMPAEARTTTLNEELGQIEYIFS 392

  Fly   614 DKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIPNDNLN--------SDMAQL 670
            |||||||:|.|.|::|.:||           ::|:  |.....|.....:.        |..::.
  Rat   393 DKTGTLTQNIMTFKKCSING-----------RVYA--GEVLDDLDQKKEITKKKEAVDFSGKSKS 444

  Fly   671 TQGTYLTPHA---------QRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLK 726
            .:..:...|:         .::.|||.:||:|:||:
  Rat   445 ERTLHFFDHSLMESIELGDPKVHEFLRLLALCHTVM----------------------------- 480

  Fly   727 HGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSH 791

  Rat   481 ----------------------------------------------------------------- 480

  Fly   792 QPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRM 856
                            ||.:|.
  Rat   481 ----------------SEEDSA------------------------------------------- 486

  Fly   857 KLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEIL 921
                           |:.:|:.:||||.|||.||.::.....:|:|..|.:.  ..|....|::|
  Rat   487 ---------------GQLVYQVQSPDEGALVTAARNFGFIFKSRTPETITIE--ELGTPVTYQLL 534

  Fly   922 KVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYARE 986
            ..|.|::.||.||::||....| |.||:||||:.:...|    |.|.|.:| ..|...|..:|.|
  Rat   535 AFLDFNNIRKRMSVIVRNPEGQ-IKLYSKGADTILFEKL----HPSNEDLL-SLTSDHLSEFAGE 593

  Fly   987 GLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGV 1051
            |||.|.:|.|.|:...:..|....::...::..|:.|:...:.::|.:|.|||||.:||:||:||
  Rat   594 GLRTLAIAYRELDDKYFKMWQKMLEDANSAIAERDERISGLYEEIERDLMLLGATAVEDKLQEGV 658

  Fly  1052 PETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQME---------LIRLTARSRDAAETAI 1107
            .|||.||..|.|.:|:|||||.||||||.|:..:.|..|:         .:.:....|.|.|..:
  Rat   659 IETITSLSLANIKIWILTGDKQETAINIGYACNVLTDAMDAVFVITGNTAVEVREELRKAKENLL 723

  Fly  1108 -------NFYLTDMENDKTTSTLGYGQSLRKKQRALVVDGKTLTFILDPKSKLILPFLRLSKRCA 1165
                   |.:.......:.....|.|::: ..:.|||::|.:|...|:  |.:....|.|:..|.
  Rat   724 GQNTSFSNGHAVYENKQRLELDSGAGETV-TGEYALVINGHSLAHALE--SDVEKDLLELACVCK 785

  Fly  1166 SVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTL 1230
            :|:|||.||||||.:|::||:..|..||||||||||||||:.|.:|:|||||||:|||:|:|:.|
  Rat   786 TVVCCRVTPLQKAQVVELVKKHRNAVTLAIGDGANDVSMIKSAHIGIGISGQEGLQAVLASDYAL 850

  Fly  1231 PRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLI 1295
            .:||||:||||.||.|.|.|:.:.:.||||||.||..:.||:..|||||.|.:.||.::.|:|::
  Rat   851 AQFRYLQRLLLVHGRWSYYRMCKFLCYFFYKNFAFTLVHFWFAFYCGFSAQTVYDQWFITLFNIV 915

  Fly  1296 FTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVALCAY- 1359
            :||||.||:||:|:.|:|...:..|.||:.|:|.:.:....|::.:...:|.||::||:...|:
  Rat   916 YTSLPVLAMGVFDQDVSEQNSMDCPQLYEPGQLNLLFNKRRFFICVAHGIYTSLILFFIPYGAFY 980

  Fly  1360 ---AESDVGIWE---FGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFY--LFAIVYDS 1416
               ||....|.:   |..|:..|.:....|..|::...|||::.:.|..|:.:::  |.|:..|.
  Rat   981 NVAAEDGQHIADYQSFAVTVATSLVIVVSVQIALDTSYWTVVNHVFIWGSVATYFSILLAMHSDG 1045

  Fly  1417 VCMNCFGV-----------RSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDS 1470
            |    ||:           |.|....||       |||::|:.|.:|:|.::...:::.|.|..|
  Rat  1046 V----FGIFPRQFPFVGNARRSLSQKFV-------WLVVLLTAVTSVMPVVVFRFLKMHLYPSLS 1099

  Fly  1471 TKV-----------ILQSKRERSRGEALLVTWSRSTSASSIYRITDYGSKNQIITT 1515
            .::           .|:|:|.::|         ||:|..|.|.........::||:
  Rat  1100 DQIRRWQKAQRKERPLRSRRPQTR---------RSSSRRSGYAFAHQEGYGELITS 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	26/49 (53%)
		ATPase-Plipid	250..1473	CDD:273734	397/1289 (31%)
		E1-E2_ATPase	302..>394	CDD:278548	37/91 (41%)
		Cation_ATPase	<880..965	CDD:289987	32/84 (38%)
		HAD_like	<1177..1240	CDD:304363	40/62 (65%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	91/264 (34%)
Atp8b4	XP_038962769.1	P-type_ATPase_APLT_Dnf-like	31..975	CDD:319770	363/1149 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920