DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and Atp8b3

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_234937.3	Gene:	Atp8b3 / 299616	RGDID:	1307622	Length:	1340	Species:	Rattus norvegicus

Alignment Length:	1316	Identity:	399/1316 - (30%)
Similarity:	625/1316 - (47%)	Gaps:	284/1316 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 QFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVT 313
            ::..|.|.|.||.:.||:|.||.|||.||:||||:||::|..:||||.........|::.:|.:.
  Rat    44 KYKSNAIHTAKYNVFSFLPLNLYEQFRRVSNLYFLFIIILQSIPEISTLPWFTLFAPLVCLLMIR 108

  Fly   314 AVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTS 378
            |.:||.:|..|..||:.|||..|::..|::..:|  ||:.|.|||:|.||.:..||||:|||.::
  Rat   109 AARDLVDDIGRHRSDRIINNRPCQILKGKSFLWK--KWKNLCVGDVVCLSKDNIVPADLLLLAST 171

  Fly   379 DPQGVCYIDTCDLDGETNLK-RREVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIHPT 442
            :|..:||::|.|:||||||| |:.::....|:.|....:.|...|..:.|.::::.|.|:| ...
  Rat   172 EPSSLCYLETADIDGETNLKFRQALMVTHHELTSPKKMASFQGIVTCEEPNSRMHHFVGSL-EWN 235

  Fly   443 GERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVII 507
            ..:.|:....||||..:::|||...|:|:|||.:||.|.|......||::::..||..||...:.
  Rat   236 SRKYPLDIGNLLLRGCKIRNTDTCYGLVIYAGLDTKIMKNCGKIHLKRTKLDLMMNKLVILIFMS 300

  Fly   508 LLILCVVGAIGCRMWLSSF--THFPVPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLYVTIEL 570
            |:|..:...:|....:..|  .|..:..:...  |..|:|.:|||.::::|.||:|:::::..|.
  Rat   301 LVIASMFLTLGFAFMVKEFKAKHHYMSSMQGR--TDAMDSFFIFWGFLILLSVMVPMAMFIIAEF 363

  Fly   571 CKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNG-- 633
            ..:.....|:.::.::....:...:.|:.::.:.|||:|:||:|||||||:|.|.|::|.:||
  Rat   364 IYLGNSIFINWDLSMYYEPLDIPAKARSTSLNDHLGQVQYIFSDKTGTLTQNIMTFKKCCINGCT 428

  Fly   634 --SDYNHPPSELEKIYS-KPGAPAPPLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNT 695
              ||..|........|| .|.|.......|..|.|    |.:|    ...:.:|||..:||||:|
  Rat   429 YDSDDEHGTLRKRNPYSWNPFADGKLQFYNKELES----LVRG----KQDRAVQEFWRLLAICHT 485

  Fly   696 VIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSI 760
            |:|
  Rat   486 VMV-------------------------------------------------------------- 488

  Fly   761 PADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNS 825

  Rat   489 ----------------------------------------------------------------- 488

  Fly   826 ISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAA 890
                                                      :..|.:.||:|.||||.|||.||
  Rat   489 ------------------------------------------QEKDNQLLYQAASPDEEALVAAA 511

  Fly   891 YSYDCCLLNRSPNQI-LVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQ-IGSQEIVLYTKGAD 953
            .::....|:|:.:.| ||.:   |..|.|::|.::.|:|.||.||::||. .||  |.|||||||
  Rat   512 RNFGYVFLSRTQDTITLVEL---GEERVYQVLAMMDFNSVRKRMSVLVRNPEGS--ICLYTKGAD 571

  Fly   954 SSIMPVLVPCSHNSPEGILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLE 1018
            :.|:..|    |:  :|::...|:::|..:|.:.||.|.:|.:.:....|.:|...|||..:.|:
  Rat   572 TVILERL----HH--KGVMEATTEEVLAAFAEQTLRTLCLAYKDVAEDAYKEWEPEHQEAALLLQ 630

  Fly  1019 NRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSA 1083
            ||.:.|...:.|||.||.|||.|.|||:|||||||||..|....|.:|||||||||||:||.::.
  Rat   631 NRAQALHQVYNKLEQNLQLLGVTAIEDKLQDGVPETIRCLKKGNIKMWVLTGDKPETAVNIGFAC 695

  Fly  1084 KLFTQQMELIRLTARSRDAAETAINFYLTDMENDKTTSTLGY--------GQ-------SLRKKQ 1133
            :|.::.|.::    ..:|......| |..:.|:.:...|:.:        |:       ||||:.
  Rat   696 QLLSENMSIL----EDKDIKGLLEN-YWDENEHQRAFQTMTHHNMALVINGEFLDQLLLSLRKEP 755

  Fly  1134 RAL----VVDGKT-------LTFIL---------------------------DPKSKLILPFLRL 1160
            |||    |||..|       |.|:.                           .|:.:....|:.|
  Rat   756 RALVQNAVVDEATQEPGVSALDFLQARRISQMWRNFGTTMATSQSDASKTRESPEERRERAFVDL 820

  Fly  1161 SKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMA 1225
            :.:|.:|:|||.||.|||.:|.:||:...:.|||||||||||:||:.||:|||::||||||||..
  Rat   821 ASKCQAVICCRVTPKQKALVVALVKKYQQVVTLAIGDGANDVNMIKTADIGVGLAGQEGMQAVQN 885

  Fly  1226 ADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLM 1290
            :|:.|.:|.||:||||.||.|.|.|:.:.:.|||||..|.:....|:.|:.|||.|.:.:..:|.
  Rat   886 SDYVLAQFCYLQRLLLVHGRWSYMRICKFLRYFFYKTVASMMAQIWFSLFNGFSAQPLYEGWFLA 950

  Fly  1291 LYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVA 1355
            |:||::::||.|.||::::.|..:..||.|.||..|:....:....|...:......||:.|||.
  Rat   951 LFNLLYSTLPVLYIGLFEQDVTAEKSLKMPELYTAGQKDELFNYSIFVQAIAHGTITSLINFFVT 1015

  Fly  1356 -LCAYAESDVG----IWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYD 1415
             |.:|..:..|    ...||..:..|.|.:..:...:.::.||:|.|.::|:||.|:.:|..:.:
  Rat  1016 ILVSYDMTKTGSSPDYQSFGVLVAISSLLSITLEVILVVKYWTLLFVGTVVVSLSSYVIFTSLTE 1080

  Fly  1416 SVCMNCFGVRSSYWVIFVCFASAVH----WLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKVILQ 1476
            |:.:  |.:....:.......:.:.    .|||:|:..:..||.|.:..:|         :.:|:
  Rat  1081 SLLL--FRISPKTFPFLFADYNVIREPSSLLVIVLNVTLNTLPMLAVRIIR---------RTVLK 1134

  Fly  1477 ---SKRERSRGEALLV 1489
               .|.|....|.|.|
  Rat  1135 RHPKKEEEVPSEELTV 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	26/49 (53%)
		ATPase-Plipid	250..1473	CDD:273734	393/1294 (30%)
		E1-E2_ATPase	302..>394	CDD:278548	37/91 (41%)
		Cation_ATPase	<880..965	CDD:289987	38/86 (44%)
		HAD_like	<1177..1240	CDD:304363	37/62 (60%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	75/253 (30%)
Atp8b3	XP_234937.3	PhoLip_ATPase_N	20..96	CDD:292826	26/51 (51%)
		ATPase-Plipid	45..1143	CDD:273734	396/1306 (30%)
		Cation_ATPase	483..577	CDD:289987	45/267 (17%)
		COG4087	<839..890	CDD:226572	30/50 (60%)
		PhoLip_ATPase_C	883..1131	CDD:292829	75/258 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830