DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and Atp8a1

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_038948654.1	Gene:	Atp8a1 / 289615	RGDID:	1309619	Length:	1209	Species:	Rattus norvegicus

Alignment Length:	1342	Identity:	408/1342 - (30%)
Similarity:	646/1342 - (48%)	Gaps:	309/1342 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 PAREPSAPTSATGGRGHSRQASRSESIYTLRRTEAPPWWKRLTLCNYNTGDKFEERS------YR 228
            |:|.|.:..|.||...|:::|.:            ||.:::       |.|..|:.|      .|
  Rat    37 PSRAPGSSYSGTGRLTHNQRARK------------PPGYEK-------TDDVSEKTSLADQEEVR 82

  Fly   229 TVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPE 293
            |:..|.   |:..|       |..|.:.|.||.:::|:|:.|..||.|.||.:|:||.||..:|:
  Rat    83 TIFINQ---PQLTK-------FCNNHVSTAKYNVITFLPRFLYSQFRRAANSFFLFIALLQQIPD 137

  Fly   294 ISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGD 358
            :|..|:...::|:||:|.|.|:|::.||.:|..:|..:|....:|.  ....::.|.|:::.|||
  Rat   138 VSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVL--RNGAWEIVHWEKVNVGD 200

  Fly   359 IVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFVSRVE 423
            ||.:...|.:|||.:||.:|:||.:|||:|.:||||||||.|:.:....:::.|....:...|:|
  Rat   201 IVIIKGKEFIPADTVLLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIKDIDSLMRISGRIE 265

  Fly   424 ADAPTTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRY 488
            .::|...||.|.|.:.......||:..:.:|||.::|:||.::.|||||.||:||.|.|::.|..
  Rat   266 CESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPL 330

  Fly   489 KRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFT----HFPVPYLPPNKLTANMESMWIF 549
            |.|.||:..|:.::....||:.:.:|.::|..:|....:    :..:.|...:....|      |
  Rat   331 KLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLHLHYGGASNFGLN------F 389

  Fly   550 WTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTD 614
            .|:|::...:||:||.||:|:.|..|.:.|:.::|:....|:.....|..|:.|||||:::||:|
  Rat   390 LTFIILFNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSD 454

  Fly   615 KTGTLTENKMIFRRCVVNGSDYNHPP--------------SEL--EKIYSKPGAPAPPLIPNDNL 663
            ||||||.|.|.|::|.:.|..|.|.|              |:.  ||.::.|.     |:.|...
  Rat   455 KTGTLTCNVMQFKKCTIAGVAYGHVPEPEDYGCSPDEWQSSQFGDEKTFNDPS-----LLENLQN 514

  Fly   664 NSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHG 728
            |.            |.|..|.|||.::|:|:|    |.|.||
  Rat   515 NH------------PTAPIICEFLTMMAVCHT----AVPERD----------------------- 540

  Fly   729 KQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQP 793

  Rat   541 ----------------------------------------------------------------- 540

  Fly   794 TLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKL 858
                                                                       |:::
  Rat   541 -----------------------------------------------------------GEKI-- 544

  Fly   859 PSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKV 923
                            :|:|.||||.|||.||...:.....|:|:.:::.  ..|....||:|.|
  Rat   545 ----------------IYQAASPDEGALVRAAKQLNFVFTGRTPDSVIID--SLGQEERYELLNV 591

  Fly   924 LPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYAREGL 988
            |.|.||||.||:||| ..|.::.||.||||:.|...|...|.      .:|.|.:.|:::|.|||
  Rat   592 LEFTSSRKRMSVVVR-TPSGKLRLYCKGADTVIYERLAESSK------YKEITLKHLEQFATEGL 649

  Fly   989 RILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPE 1053
            |.|..|...::.:|:.:|.|.:|....|::||..:|.:|:..:|.||.|||||.|||:|||.|||
  Rat   650 RTLCFAVAEISESDFEEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPE 714

  Fly  1054 TIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTDMENDK 1118
            ||.:|:.|.|.:|:|||||.||||||.:|.:|..:.|.:|.:...|.|.....::.:.|.:
  Rat   715 TIETLMKADIKIWILTGDKQETAINIGHSCRLLRRNMGMIVINEGSLDGTRETLSRHCTTL---- 775

  Fly  1119 TTSTLGYGQSLRKKQR-ALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVK 1182
                   |.:|||:.. ||::|||||.:.|....:..  ||.|:..|.:|:|||.:||||:.:|:
  Rat   776 -------GDALRKENDFALIIDGKTLKYALTFGVRQY--FLDLALSCKAVICCRVSPLQKSEVVE 831

  Fly  1183 VVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWC 1247
            :||:::.:.|||||||||||||||.|.|||||||.||:||..::|:::.:|:||:.||:.||.|.
  Rat   832 MVKKQVKVITLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMVHGAWN 896

  Fly  1248 YDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVA 1312
            |:|:|:.|||.||||.....:..|:....|||||::.::..:.|||::||::|||.:|::::...
  Rat   897 YNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCR 961

  Fly  1313 EDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVALCAYAESDVGIWEFGTTITAS- 1376
            ::.:||.|.|||..:..:.:....||:..|:.|:.|:::|:..|.|.....|    ||...|:.
  Rat   962 KENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTV----FGNGKTSDY 1022

  Fly  1377 CLFANLVH----------CAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVI 1431
            .|..|.|:          ..:|...||....::|..|:..:.:|           ||:.||.|..
  Rat  1023 LLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVF-----------FGIYSSLWPA 1076

  Fly  1432 F-----------VCFASAVHWLVIMLSTVVAVLPRLLLTTVR 1462
            .           :.|:|.|.|:.::...|.::|..:|...::
  Rat  1077 VPMAPDMSGEAAMLFSSGVFWVGLLSIPVASLLLDVLYKVIK 1118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	20/49 (41%)
		ATPase-Plipid	250..1473	CDD:273734	389/1256 (31%)
		E1-E2_ATPase	302..>394	CDD:278548	35/91 (38%)
		Cation_ATPase	<880..965	CDD:289987	36/84 (43%)
		HAD_like	<1177..1240	CDD:304363	35/62 (56%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	73/262 (28%)
Atp8a1	XP_038948654.1	ATPase-Plipid	94..1131	CDD:273734	389/1256 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.930