Protein Alignment CG33298 and ATP11C

DIOPT Version :10

• Sequence 1: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Sequence 2: XP_047297972.1
• Gene: ATP11C / 286410
• HGNCID: 13554
• Length: 1153
• Species: Homo sapiens
• Alignment Length: 1375
• Identity: 403/1375 - (29%)
• Similarity: 620/1375 - (45%)
• Gaps: 317/1375 - (23%)

  Fly   164 PGHKEEPAR------EPSAPTSATGGRGHSRQASRSESIYTLRRTEAPPWWKRLTLCNYNTGDKF 222
            |.|:..|||      :|..|.:..   ..|.|.:..|              ||:
Human     5 PSHRSPPARLLELLTDPQIPEAVC---APSSQCAGEE--------------KRV----------- 41

  Fly   223 EERSYRTV-VPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIV 286
               ..||| |.||   |.:....:...:|..|:|.::||||.:|:||||.|||.|:||.||:.|.
Human    42 ---GTRTVFVGNH---PVSETEAYIAQRFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIF 100

  Fly   287 LLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKW 351
            |:. |...:......:.:|:.||:.|||:|..:||..|..:|..:|.:|  ||..|..:..:.:.
Human   101 LVQ-VTVDTPTSPVTSGLPLFFVITVTAIKQGYEDCLRHRADNEVNKST--VYIIENAKRVRKES 162

  Fly   352 QELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPS 416
            ::::|||:|.:..:||.|.|::||.:....|.||:.|..||||:|.|....||....:.:.....
Human   163 EKIKVGDVVEVQADETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIALCTAESID 227

  Fly   417 KFVSRVEADAPTTKLYRFHGAL-IHPTG-ERV--PISTECLLLRESRLKNTDYIEGIVVYAGHET 477
            ...:.:|.:.|...||:|.|.: |:... |.|  .:..|.|||:.:.||||:.|.|:.||.|.||
Human   228 TLRAAIECEQPQPDLYKFVGRINIYSNSLEAVARSLGPENLLLKGATLKNTEKIYGVAVYTGMET 292

  Fly   478 KSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFPVPYLPP----NK 538
            |..||..|...|||.||:.:|..:|..:.|||....|......:|.|:      ||...    .|
Human   293 KMALNYQGKSQKRSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWQST------PYNDEPWYNQK 351

  Fly   539 LTANMESMWI------FWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECR 597
            .....|::.:      |.:::|:...:||:|:|||:|:.|.|..|.|..:.|.:|.|.|:.....
Human   352 TQKERETLKVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDKDFYDEEINEGALVN 416

  Fly   598 AMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIPNDN 662
            ..::.|||||:.::|||||||||||.|.|..|.::|..|.....|::.:....|.    |...|.
Human   417 TSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKYKGVTQEVDGLSQTDGT----LTYFDK 477

  Fly   663 LNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKH 727
            ::.:..:|               ||..|.:|:||                 |::
Human   478 VDKNREEL---------------FLRALCLCHTV-----------------EIK----------- 499

  Fly   728 GKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQ 792
                            |...::|.|                 ||..:|
Human   500 ----------------TNDAVDGAT-----------------ESAELT----------------- 514

  Fly   793 PTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMK 857
                                                                             
Human   515 ----------------------------------------------------------------- 514

  Fly   858 LPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLN------RSPNQILVSMPMAGATR 916
                              |.:.||||:|||..|..|....|.      |..||       .....
Human   515 ------------------YISSSPDEIALVKGAKRYGFTFLGNRNGYMRVENQ-------RKEIE 554

  Fly   917 EYEILKVLPFDSSRKCMSIVVR-QIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLL 980
            |||:|..|.||:.|:.||::|: |.|  :|:|:.|||||::.|.:.  :|..      |.|:..:
Human   555 EYELLHTLNFDAVRRRMSVIVKTQEG--DILLFCKGADSAVFPRVQ--NHEI------ELTKVHV 609

  Fly   981 DRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIED 1045
            :|.|.:|.|.|.:|.:.:...||.....:..|.:|:|::||.::...|..:|:|:.|:|||.:||
Human   610 ERNAMDGYRTLCVAFKEIAPDDYERINRQLIEAKMALQDREEKMEKVFDDIETNMNLIGATAVED 674

  Fly  1046 RLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTA-------RSRDAA 1103
            :|||...|||.:|.:||:.||||||||.|||.:..|:.:||....||:.||.       |..|..
Human   675 KLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLELTTKTIEESERKEDRL 739

  Fly  1104 ETAINFYLTDMENDKTTSTLGYGQSLRKKQR-ALVVDGKTLTFILDPKS-------KLILPFLRL 1160
            ...:..|...:.::...||..:.::..:.|. .|::||.||:.||:...       |.|  ||::
Human   740 HELLIEYRKKLLHEFPKSTRSFKKAWTEHQEYGLIIDGSTLSLILNSSQDSSSNNYKSI--FLQI 802

  Fly  1161 SKRCASVLCCRSTPLQKAYLVKVVKEELNLR----TLAIGDGANDVSMIQMADVGVGISGQEGMQ 1221
            ..:|.:|||||..|||||.:|::||   ||:    ||:|||||||||||..:.||:||.|:||.|
Human   803 CMKCTAVLCCRMAPLQKAQIVRMVK---NLKGSPITLSIGDGANDVSMILESHVGIGIKGKEGRQ 864

  Fly  1222 AVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQ 1286
            |...:|:::|:|::|::||||||:..|.|::.::.||||||..|:...|.||.:||||.|.:.|.
Human   865 AARNSDYSVPKFKHLKKLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDA 929

  Fly  1287 MYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYK--NGRLGVAYRPHDFWLILLDALYQSL 1349
            .||.:||:.|||||.||..:.::.:..|.|..:|.||.  :|...:...|..:|..|  |.::..
Human   930 AYLTMYNICFTSLPILAYSLLEQHINIDTLTSDPRLYMKISGNAMLQLGPFLYWTFL--AAFEGT 992

  Fly  1350 VIFFVALCAYAESDV-------GIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSF 1407
            |.||.....:..:.:       |.|.|||.:....:|...:..|::.|.||.::...|..||..:
Human   993 VFFFGTYFLFQTASLEENGKVYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWINHFVIWGSLAFY 1057

  Fly  1408 YLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTK 1472
            ..|:..:..:.......:..|:|.....:|...||.|:|...:::.|.:||
Human  1058 VFFSFFWGGIIWPFLKQQRMYFVFAQMLSSVSTWLAIILLIFISLFPEILL-------------- 1108

  Fly  1473 VILQSKRERS 1482
            ::|::.|.||
Human  1109 IVLKNVRRRS 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	355/1144 (31%)
ATP11C	XP_047297972.1	P-type_ATPase_APLT_Dnf-like	66..998	CDD:319770	355/1144 (31%)
		PhoLip_ATPase_C	886..1113	CDD:465071	69/242 (29%)