Protein Alignment CG33298 and ATP11A

DIOPT Version :10

• Sequence 1: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Sequence 2: NP_001392590.1
• Gene: ATP11A / 23250
• HGNCID: 13552
• Length: 1192
• Species: Homo sapiens
• Alignment Length: 1346
• Identity: 405/1346 - (30%)
• Similarity: 637/1346 - (47%)
• Gaps: 276/1346 - (20%)

  Fly   228 RTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWV- 291
            ||:...|..||...:...|. ::..|:|.::|||..:||||||.|||.||||.||:.|.|:..:
Human    24 RTIYVGHREPPPGAEAYIPQ-RYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLIIFLVQLII 87

  Fly   292 -----PEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKW 351
                 |..|.       :|:.||:.|||:|..:||..|..:|..:|.  |.|:..:..:..:.:.
Human    88 DTPTSPVTSG-------LPLFFVITVTAIKQGYEDWLRHKADNAMNQ--CPVHFIQHGKLVRKQS 143

  Fly   352 QELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVV---RGFEEMQSIF 413
            ::|||||||.:..:||.|.|::.|.::...|.|::.|..||||::.|....|   :||...:.|
Human   144 RKLRVGDIVMVKEDETFPCDLIFLSSNRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDI- 207

  Fly   414 VPSKFVSRVEADAPTTKLYRFHGAL-----IHPTGERVPISTECLLLRESRLKNTDYIEGIVVYA 473
              ....:.:|.:.|...||:|.|.:     ::....| |:.:|.||||.:.||||:.|.|:.:|.
Human   208 --GGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVR-PLGSENLLLRGATLKNTEKIFGVAIYT 269

  Fly   474 GHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFPVPYLPP-- 536
            |.|||..||......|||.||:.||..:|..:.||:...::..:...||.|.      |:...
Human   270 GMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSE------PFRDEPW 328

  Fly   537 -NKLTAN-------MESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQ 593
             |:.|.:       :::...|..::|:...:||:|:|||:|:.|.|..:.|..:.|:||.||.:.
Human   329 YNQKTESERQRNLFLKAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEG 393

  Fly   594 TECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLI 658
            ......::.|||||:::||||||||||||.|.|:.|.:.|..|
Human   394 PLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVY---------------------- 436

  Fly   659 PNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPA 723
                              .||           .|||..:        :..:|||   ..|.:||:
Human   437 ------------------VPH-----------VICNGQV--------LPESSGI---DMIDSSPS 461

  Fly   724 NLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPA 788
              .:|::|::|...:.....|..:
Human   462 --VNGREREELFFRALCLCHTVQV----------------------------------------- 483

  Fly   789 QSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQG 853
                               .:.:|...|.|        ||.|....|
Human   484 -------------------KDDDSVDGPRK--------SPDGGKSCV------------------ 503

  Fly   854 KRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREY 918
                                  |.:.||||:|||..........|....|.:.: :........:
Human   504 ----------------------YISSSPDEVALVEGVQRLGFTYLRLKDNYMEI-LNRENHIERF 545

  Fly   919 EILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRY 983
            |:|::|.|||.|:.||::|:. .:.||.|:.|||||||.|.::       ||.: :|.:..::|.
Human   546 ELLEILSFDSVRRRMSVIVKS-ATGEIYLFCKGADSSIFPRVI-------EGKV-DQIRARVERN 601

  Fly   984 AREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQ 1048
            |.||||.|.:|.:.|...:|.......|..:::|::||::|.:::.::|.:|||||||.:|||||
Human   602 AVEGLRTLCVAYKRLIQEEYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQ 666

  Fly  1049 DGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTD 1113
            :...:||.:|..|||.||||||||.|||....|:.|||.:..:|:.||.:..:  |.:::..|.:
Human   667 EKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQLLELTTKRIE--EQSLHDVLFE 729

  Fly  1114 M-------ENDKTTSTLGYGQSLRKKQRALVVDGKTLTFILDPKS--------KLILPFLRLSKR 1163
            :       ....|...|. |.|...:...|::||..|:.|:.|:.        :|   ||.:.:.
Human   730 LSKTVLRHSGSLTRDNLS-GLSADMQDYGLIIDGAALSLIMKPREDGSSGNYREL---FLEICRS 790

  Fly  1164 CASVLCCRSTPLQKAYLVKVVK-EELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAAD 1227
            |::|||||..|||||.:||::| .:.:..||||||||||||||..|.||:|:.|:||.||...:|
Human   791 CSAVLCCRMAPLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSD 855

  Fly  1228 FTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLY 1292
            :.:|:|::|:::||.||::.|.|:|.::.||||||..|:|..|.||.:||||.|.:.|..||.||
Human   856 YAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLY 920

  Fly  1293 NLIFTSLPPLAIGVYDKRVAEDLLLKNPYLY----KNGRLGVAYRPHDFWLILLDALYQSLVIFF 1353
            |:.|||||.|...:.::.|..|:|.::|.||    ||..|  .:|...:|.:|  .|:.:||.||
Human   921 NISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALL--RWRVFIYWTLL--GLFDALVFFF 981

  Fly  1354 VALCAYAESDV-------GIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFA 1411
            .|...:..:.|       |.|.|||.:....:|...:..|::...||.::...|..||..:.:|:
Human   982 GAYFVFENTTVTSNGQIFGNWTFGTLVFTVMVFTVTLKLALDTHYWTWINHFVIWGSLLFYVVFS 1046

  Fly  1412 IVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKVILQ 1476
            :::..|.......:..|:|.....:|...||.|:|...:::||.:|...:...|.| .:|:.:.|
Human  1047 LLWGGVIWPFLNYQRMYYVFIQMLSSGPAWLAIVLLVTISLLPDVLKKVLCRQLWP-TATERVQQ 1110

  Fly  1477 S----KRERSRGEALLVTWS----RSTSASSIYRITDYGSKNQIIT 1514
            :    .|:|......|.:..    :||..|:.:    |.|.:|.:|
Human  1111 NGCAQPRDRDSEFTPLASLQSPGYQSTCPSAAW----YSSHSQQVT 1152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	359/1146 (31%)
ATP11A	NP_001392590.1	P-type_ATPase_APLT_Dnf-like	47..983	CDD:319770	359/1146 (31%)
		RDD	<965..1061	CDD:469900	23/97 (24%)