DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and ATP11A

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_005268356.1	Gene:	ATP11A / 23250	HGNCID:	13552	Length:	1192	Species:	Homo sapiens

Alignment Length:	1346	Identity:	405/1346 - (30%)
Similarity:	637/1346 - (47%)	Gaps:	276/1346 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 RTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWV- 291
            ||:...|..||...:...|. ::..|:|.::|||..:||||||.|||.||||.||:.|.|:..:
Human    24 RTIYVGHREPPPGAEAYIPQ-RYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLIIFLVQLII 87

  Fly   292 -----PEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKW 351
                 |..|.       :|:.||:.|||:|..:||..|..:|..:|.  |.|:..:..:..:.:.
Human    88 DTPTSPVTSG-------LPLFFVITVTAIKQGYEDWLRHKADNAMNQ--CPVHFIQHGKLVRKQS 143

  Fly   352 QELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVV---RGFEEMQSIF 413
            ::|||||||.:..:||.|.|::.|.::...|.|::.|..||||::.|....|   :||...:.|
Human   144 RKLRVGDIVMVKEDETFPCDLIFLSSNRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDI- 207

  Fly   414 VPSKFVSRVEADAPTTKLYRFHGAL-----IHPTGERVPISTECLLLRESRLKNTDYIEGIVVYA 473
              ....:.:|.:.|...||:|.|.:     ::....| |:.:|.||||.:.||||:.|.|:.:|.
Human   208 --GGLHATIECEQPQPDLYKFVGRINVYSDLNDPVVR-PLGSENLLLRGATLKNTEKIFGVAIYT 269

  Fly   474 GHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFPVPYLPP-- 536
            |.|||..||......|||.||:.||..:|..:.||:...::..:...||.|.      |:...
Human   270 GMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVLKYMWQSE------PFRDEPW 328

  Fly   537 -NKLTAN-------MESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQ 593
             |:.|.:       :::...|..::|:...:||:|:|||:|:.|.|..:.|..:.|:||.||.:.
Human   329 YNQKTESERQRNLFLKAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEG 393

  Fly   594 TECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLI 658
            ......::.|||||:::||||||||||||.|.|:.|.:.|..|
Human   394 PLVNTSDLNEELGQVEYIFTDKTGTLTENNMEFKECCIEGHVY---------------------- 436

  Fly   659 PNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPA 723
                              .||           .|||..:        :..:|||   ..|.:||:
Human   437 ------------------VPH-----------VICNGQV--------LPESSGI---DMIDSSPS 461

  Fly   724 NLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPA 788
              .:|::|::|...:.....|..:
Human   462 --VNGREREELFFRALCLCHTVQV----------------------------------------- 483

  Fly   789 QSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQG 853
                               .:.:|...|.|        ||.|....|
Human   484 -------------------KDDDSVDGPRK--------SPDGGKSCV------------------ 503

  Fly   854 KRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREY 918
                                  |.:.||||:|||..........|....|.:.: :........:
Human   504 ----------------------YISSSPDEVALVEGVQRLGFTYLRLKDNYMEI-LNRENHIERF 545

  Fly   919 EILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRY 983
            |:|::|.|||.|:.||::|:. .:.||.|:.|||||||.|.::       ||.: :|.:..::|.
Human   546 ELLEILSFDSVRRRMSVIVKS-ATGEIYLFCKGADSSIFPRVI-------EGKV-DQIRARVERN 601

  Fly   984 AREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQ 1048
            |.||||.|.:|.:.|...:|.......|..:::|::||::|.:::.::|.:|||||||.:|||||
Human   602 AVEGLRTLCVAYKRLIQEEYEGICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQ 666

  Fly  1049 DGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTD 1113
            :...:||.:|..|||.||||||||.|||....|:.|||.:..:|:.||.:..:  |.:::..|.:
Human   667 EKAADTIEALQKAGIKVWVLTGDKMETAAATCYACKLFRRNTQLLELTTKRIE--EQSLHDVLFE 729

  Fly  1114 M-------ENDKTTSTLGYGQSLRKKQRALVVDGKTLTFILDPKS--------KLILPFLRLSKR 1163
            :       ....|...|. |.|...:...|::||..|:.|:.|:.        :|   ||.:.:.
Human   730 LSKTVLRHSGSLTRDNLS-GLSADMQDYGLIIDGAALSLIMKPREDGSSGNYREL---FLEICRS 790

  Fly  1164 CASVLCCRSTPLQKAYLVKVVK-EELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAAD 1227
            |::|||||..|||||.:||::| .:.:..||||||||||||||..|.||:|:.|:||.||...:|
Human   791 CSAVLCCRMAPLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSD 855

  Fly  1228 FTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLY 1292
            :.:|:|::|:::||.||::.|.|:|.::.||||||..|:|..|.||.:||||.|.:.|..||.||
Human   856 YAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLY 920

  Fly  1293 NLIFTSLPPLAIGVYDKRVAEDLLLKNPYLY----KNGRLGVAYRPHDFWLILLDALYQSLVIFF 1353
            |:.|||||.|...:.::.|..|:|.::|.||    ||..|  .:|...:|.:|  .|:.:||.||
Human   921 NISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDVAKNALL--RWRVFIYWTLL--GLFDALVFFF 981

  Fly  1354 VALCAYAESDV-------GIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFA 1411
            .|...:..:.|       |.|.|||.:....:|...:..|::...||.::...|..||..:.:|:
Human   982 GAYFVFENTTVTSNGQIFGNWTFGTLVFTVMVFTVTLKLALDTHYWTWINHFVIWGSLLFYVVFS 1046

  Fly  1412 IVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKVILQ 1476
            :::..|.......:..|:|.....:|...||.|:|...:::||.:|...:...|.| .:|:.:.|
Human  1047 LLWGGVIWPFLNYQRMYYVFIQMLSSGPAWLAIVLLVTISLLPDVLKKVLCRQLWP-TATERVQQ 1110

  Fly  1477 S----KRERSRGEALLVTWS----RSTSASSIYRITDYGSKNQIIT 1514
            :    .|:|......|.:..    :||..|:.:    |.|.:|.:|
Human  1111 NGCAQPRDRDSEFTPLASLQSPGYQSTCPSAAW----YSSHSQQVT 1152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	24/55 (44%)
		ATPase-Plipid	250..1473	CDD:273734	388/1273 (30%)
		E1-E2_ATPase	302..>394	CDD:278548	31/91 (34%)
		Cation_ATPase	<880..965	CDD:289987	30/84 (36%)
		HAD_like	<1177..1240	CDD:304363	32/63 (51%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	83/255 (33%)
ATP11A	XP_005268356.1	PhoLip_ATPase_N	42..95	CDD:292826	24/53 (45%)
		ATPase-Plipid	45..1110	CDD:273734	388/1276 (30%)
		E1-E2_ATPase	102..>187	CDD:278548	31/86 (36%)
		Cation_ATPase	477..585	CDD:289987	38/217 (18%)
		R3H	639..695	CDD:294210	31/55 (56%)
		HAD_like	<806..849	CDD:304363	24/42 (57%)
		PhoLip_ATPase_C	851..1103	CDD:292829	84/256 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820