DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and ATP11B

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_055431.1	Gene:	ATP11B / 23200	HGNCID:	13553	Length:	1177	Species:	Homo sapiens

Alignment Length:	1361	Identity:	416/1361 - (30%)
Similarity:	619/1361 - (45%)	Gaps:	280/1361 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 RTVVPNHTVPPK---TPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLN 289
            ||:...:..|..   ||::      |:.|:|.::|||:.:|:||||.|||.||||.||:.|.|:.
Human    20 RTIYVANRFPQNGLYTPQK------FIDNRIISSKYTVWNFVPKNLFEQFRRVANFYFLIIFLVQ 78

  Fly   290 WV------PEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKK 348
            .:      |..|.       :|:.||:.|||:|..:||..|..||..:|...  ||...:....|
Human    79 LMIDTPTSPVTSG-------LPLFFVITVTAIKQGYEDWLRHNSDNEVNGAP--VYVVRSGGLVK 134

  Fly   349 VKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIF 413
            .:.:.:||||||.::.:|..|||::||.:....|.|::.|..||||||||....|.....:|::.
Human   135 TRSKNIRVGDIVRIAKDEIFPADLVLLSSDRLDGSCHVTTASLDGETNLKTHVAVPETALLQTVA 199

  Fly   414 VPSKFVSRVEADAPTTKLYRFHGALI--HPTGERV-PISTECLLLRESRLKNTDYIEGIVVYAGH 475
            .....|:.:|...|...||||.|.:|  ....|.| |:..|.||||.:|||||..|.|:.||.|.
Human   200 NLDTLVAVIECQQPEADLYRFMGRMIITQQMEEIVRPLGPESLLLRGARLKNTKEIFGVAVYTGM 264

  Fly   476 ETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFPVPYLPPNKLT 540
            |||..||......|||.||:.||..:|..::||:...|:..|....|.:. ..:..|:.  |:.|
Human   265 ETKMALNYKSKSQKRSAVEKSMNTFLIIYLVILISEAVISTILKYTWQAE-EKWDEPWY--NQKT 326

  Fly   541 ANMES-------MWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRA 598
            .:..:       :..|..::|:...:||:|||||:|:.|.|..|.|..::||:..|::::.:...
Human   327 EHQRNSSKILRFISDFLAFLVLYNFIIPISLYVTVEMQKFLGSFFIGWDLDLYHEESDQKAQVNT 391

  Fly   599 MNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIPNDNL 663
            .::.|||||::::|||||||||||:|.||.|.:||..|......|     .|..|.|     |:.
Human   392 SDLNEELGQVEYVFTDKTGTLTENEMQFRECSINGMKYQEINGRL-----VPEGPTP-----DSS 446

  Fly   664 NSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHG 728
            ..:::.|:..::|.                                              ||.|
Human   447 EGNLSYLSSLSHLN----------------------------------------------NLSH- 464

  Fly   729 KQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQP 793
                           .||
Human   465 ---------------LTT----------------------------------------------- 467

  Fly   794 TLSPISSSAESSPNSESESPSPP---MKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKR 855
                 |||..:||.:|:|.....   .|..||.:::            :|:::.|........:.
Human   468 -----SSSFRTSPENETELIKEHDLFFKAVSLCHTV------------QISNVQTDCTGDGPWQS 515

  Fly   856 MKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEI 920
            ...||...            |.|.||||.|||.||.......:..|...:.|.  ..|....|::
Human   516 NLAPSQLE------------YYASSPDEKALVEAAARIGIVFIGNSEETMEVK--TLGKLERYKL 566

  Fly   921 LKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYAR 985
            |.:|.|||.|:.||::| |..|.|.:|:.|||:|||:|..:        |...|:|:..:|.:|.
Human   567 LHILEFDSDRRRMSVIV-QAPSGEKLLFAKGAESSILPKCI--------GGEIEKTRIHVDEFAL 622

  Fly   986 EGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDG 1050
            :|||.|.:|.|...|.:|.:...|..|...:|:.||.:|...|..:|.:|.|||||.:||||||.
Human   623 KGLRTLCIAYRKFTSKEYEEIDKRIFEARTALQQREEKLAAVFQFIEKDLILLGATAVEDRLQDK 687

  Fly  1051 VPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTDME 1115
            |.|||.:|..|||.||||||||.|||::::.|...|.:.|.::.|.
Human   688 VRETIEALRMAGIKVWVLTGDKHETAVSVSLSCGHFHRTMNILELI------------------- 733

  Fly  1116 NDKTTSTLGYGQSLRKK----------QRALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCC 1170
            |.|:.|..  .:.||:.          |..|||||.:|:..|....||   |:.:.:.|::||||
Human   734 NQKSDSEC--AEQLRQLARRITEDHVIQHGLVVDGTSLSLALREHEKL---FMEVCRNCSAVLCC 793

  Fly  1171 RSTPLQKAYLVKVVK--EELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRF 1233
            |..|||||.:::::|  .|..: |||:|||||||||||.|.||:||.|:||.||...:|:.:.||
Human   794 RMAPLQKAKVIRLIKISPEKPI-TLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYAIARF 857

  Fly  1234 RYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTS 1298
            ::|.:||..||::.|.|::.::.||||||..|:...|.||.||.||.|.:.|.:||.|||:.|||
Human   858 KFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLTLYNICFTS 922

  Fly  1299 LPPLAIGVYDKRVAEDLLLKNPYLYKN---GRLGVAYRPHDFWLILLDALYQSLVIFFVALCAYA 1360
            ||.|...:.::.|...:|...|.||::   .|| ::.:...:|.||  ....:.:.||.:.....
Human   923 LPILIYSLLEQHVDPHVLQNKPTLYRDISKNRL-LSIKTFLYWTIL--GFSHAFIFFFGSYLLIG 984

  Fly  1361 ESD--------VGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSV 1417
            :..        .|.|.|||.:....:....|..|:|...||.::.|....|:..:::|::.|..:
Human   985 KDTSLLGNGQMFGNWTFGTLVFTVMVITVTVKMALETHFWTWINHLVTWGSIIFYFVFSLFYGGI 1049

  Fly  1418 CMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKVILQSKR--- 1479
            .....|.::.|:|.....:|...|..|:|..|..:...::.......|.|..:.|..|....
Human  1050 LWPFLGSQNMYFVFIQLLSSGSAWFAIILMVVTCLFLDIIKKVFDRHLHPTSTEKAQLTETNAGI 1114

  Fly  1480 -----------------------ERSRGEALLVTWSRSTSASSIYRITDYGSKNQIITTIT 1517
                                   ||..|.......|||.|||..:    |.:...|:|..|
Human  1115 KCLDSMCCFPEGEAACASVGRMLERVIGRCSPTHISRSWSASDPF----YTNDRSILTLST 1171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	24/55 (44%)
		ATPase-Plipid	250..1473	CDD:273734	396/1264 (31%)
		E1-E2_ATPase	302..>394	CDD:278548	33/91 (36%)
		Cation_ATPase	<880..965	CDD:289987	33/84 (39%)
		HAD_like	<1177..1240	CDD:304363	32/64 (50%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	72/255 (28%)
ATP11B	NP_055431.1	PhoLip_ATPase_N	35..89	CDD:292826	25/59 (42%)
		ATPase-Plipid	39..1106	CDD:273734	397/1265 (31%)
		E1-E2_ATPase	96..>180	CDD:278548	32/85 (38%)
		Cation_ATPase	494..605	CDD:289987	40/137 (29%)
		HAD_like	629..868	CDD:304363	106/263 (40%)
		PhoLip_ATPase_C	847..1100	CDD:292829	72/255 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820