Protein Alignment CG33298 and ATP10B

DIOPT Version :10

• Sequence 1: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Sequence 2: NP_079429.2
• Gene: ATP10B / 23120
• HGNCID: 13543
• Length: 1461
• Species: Homo sapiens
• Alignment Length: 1379
• Identity: 549/1379 - (39%)
• Similarity: 789/1379 - (57%)
• Gaps: 175/1379 - (12%)

  Fly   232 PNHTVPPKTPKRDH------------PNG------------QFVGNKIRTTKYTLLSFIPKNLLE 272
            |:.|.|..:|::..            ||.            ::.||:..||||||.:|:|:||.|
Human    24 PSETTPLLSPEKGRQSYNLTQQRVVFPNNSIFHQDWEEVSRRYPGNRTCTTKYTLFTFLPRNLFE 88

  Fly   273 QFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCR 337
            ||||.|||||:|:|:|||:|.:..|.:|:.|:|:..||.|..:||..||.:|...||.||.:..|
Human    89 QFHRWANLYFLFLVILNWMPSMEVFHREITMLPLAIVLFVIMIKDGMEDFKRHRFDKAINCSNIR 153

  Fly   338 VYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREV 402
            :|:.:.:.|.:..|:::||||.:.:..||.||||||||.:|||.|:|:::|..||||||||:|.|
Human   154 IYERKEQTYVQKCWKDVRVGDFIQMKCNEIVPADILLLFSSDPNGICHLETASLDGETNLKQRCV 218

  Fly   403 VRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIE 467
            |:||.:.:..|.|..|.:.:..:.|...|.:|.|.:.||...|.....|.||||...::||:...
Human   219 VKGFSQQEVQFEPELFHNTIVCEKPNNHLNKFKGYMEHPDQTRTGFGCESLLLRGCTIRNTEMAV 283

  Fly   468 GIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFP-- 530
            |||:|||||||:||||||||||||::|::||||:.:|:.||:::|::||:|..:|..:|...|
Human   284 GIVIYAGHETKAMLNNSGPRYKRSKIERRMNIDIFFCIGILILMCLIGAVGHSIWNGTFEEHPPF 348

  Fly   531 -VPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQT 594
             ||....:.|.:.:...::|.|.|::|||:||:||||:|||.|:.|||.:.|::||:|.||:...
Human   349 DVPDANGSFLPSALGGFYMFLTMIILLQVLIPISLYVSIELVKLGQVFFLSNDLDLYDEETDLSI 413

  Fly   595 ECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIP 659
            :|||:||.|:|||||:||:|||||||||||:||||.:.||:|:|  .|..|....|
Human   414 QCRALNIAEDLGQIQYIFSDKTGTLTENKMVFRRCTIMGSEYSH--QENAKRLETP--------- 467

  Fly   660 NDNLNSDMAQLTQGTYLT--------PHAQRIQEFLVVLAICNTVIVGAAPHRDMMNA----SGI 712
             ..|:||..:.||...|:        |...|.|:             ||.|.|...:|    .|.
Human   468 -KELDSDGEEWTQYQCLSFSARWAQDPATMRSQK-------------GAQPLRRSQSARVPIQGH 518

  Fly   713 IEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTT---------------QPQVVSIP- 761
            ...:.:|       |.:..|..:|.|:|.....|......|               :|...|:.
Human   519 YRQRSMG-------HRESSQPPVAFSSSIEKDVTPDKNLLTKVRDAALWLETLSDSRPAKASLST 576

  Fly   762 ----ADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSL 822
                ||.::.|....||..|....     |.|  :.|:.| ||.|..:...:.:.....:|..||
Human   577 TSSIADFFLALTICNSVMVSTTTE-----PRQ--RVTIKP-SSKALGTSLEKIQQLFQKLKLLSL 633

  Fly   823 SNSISPTGRAKAVINSKI-TSIATFLNAKTQGKRMKLPSSKT------------GTIYRTADGRP 874
            |.|.|.|..:...:...: .::||..:.:.....:......|            |.|..:..|..
Human   634 SQSFSSTAPSDTDLGESLGANVATTDSDERDDASVCSGGDSTDDGGYRSSMWDQGDILESGSGTS 698

  Fly   875 L-----------------YEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILK 922
            |                 ||||||||.|||:||::|...|::|:|.|:.|.:|. |....:.:|.
Human   699 LEEALEAPATDLARPEFCYEAESPDEAALVHAAHAYSFTLVSRTPEQVTVRLPQ-GTCLTFSLLC 762

  Fly   923 VLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIM-----PVLVPCSHNSPEGI--LREQTQQLL 980
            .|.|||.||.||:|||...:.|||:|||||||.||     |..|| ..|..:.:  :|.:||:.|
Human   763 TLGFDSVRKRMSVVVRHPLTGEIVVYTKGADSVIMDLLEDPACVP-DINMEKKLRKIRARTQKHL 826

  Fly   981 DRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIED 1045
            |.|||:|||.|.:||:.::..|:..|.:..:|.|.||:||:..|.::...||:.|||||||||||
Human   827 DLYARDGLRTLCIAKKVVSEEDFRRWASFRREAEASLDNRDELLMETAQHLENQLTLLGATGIED 891

  Fly  1046 RLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFY 1110
            |||:|||:|||:|..|||.:|||||||.|||:|||:|.:|..|...:..:...:::..|:.:|..
Human   892 RLQEGVPDTIATLREAGIQLWVLTGDKQETAVNIAHSCRLLNQTDTVYTINTENQETCESILNCA 956

  Fly  1111 LTDM----ENDKTTSTLGYGQSLRKK-----------QRALVVDGKTLTFILDPKSKLILPFLRL 1160
            |.::    |..|....| :|..|..|           :..||:|||||..|.  :.||...||.|
Human   957 LEELKQFRELQKPDRKL-FGFRLPSKTPSITSEAVVPEAGLVIDGKTLNAIF--QGKLEKKFLEL 1018

  Fly  1161 SKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMA 1225
            ::.|.||||||||||||:.:||:|:::|.:.||:||||||||||||.||:|:||||||||||||:
Human  1019 TQYCRSVLCCRSTPLQKSMIVKLVRDKLRVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMS 1083

  Fly  1226 ADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLM 1290
            :||.:.||::|::|||.||:|||.||:||::|:.|||..:|.|:||||.:||||...|:|...::
Human  1084 SDFAITRFKHLKKLLLVHGHWCYSRLARMVVYYLYKNVCYVNLLFWYQFFCGFSSSTMIDYWQMI 1148

  Fly  1291 LYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVA 1355
            .:||.|||||||..||.||.::.:.||..|.|||:|:....|....||:.::||.||||:.||:.
Human  1149 FFNLFFTSLPPLVFGVLDKDISAETLLALPELYKSGQNSECYNLSTFWISMVDAFYQSLICFFIP 1213

  Fly  1356 LCAYAESDVGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSF---YLFAIVYDSV 1417
            ..||..||:.::.|||.|....|...|:|.|:|:::||:.|  .:|| ||||   :|.:::|::.
Human  1214 YLAYKGSDIDVFTFGTPINTISLTTILLHQAMEMKTWTIFH--GVVL-LGSFLMYFLVSLLYNAT 1275

  Fly  1418 CMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPR-------------LLLTTVRISLCPDD 1469
            |:.|....:.|||:....::...:||..|:.|||:|||             |:....:|...|.|
Human  1276 CVICNSPTNPYWVMEGQLSNPTFYLVCFLTPVVALLPRYFFLSLQGTCGKSLISKAQKIDKLPPD 1340

  Fly  1470 STKVILQSKRERSR 1483
            ...:.:||.|.|.|
Human  1341 KRNLEIQSWRSRQR 1354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	496/1189 (42%)
ATP10B	NP_079429.2	P-type_ATPase_APLT_Dnf-like	68..1213	CDD:319770	496/1189 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..541		14/64 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	640..687		4/46 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1346..1397		5/9 (56%)