DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and ATP10B

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001353581.1	Gene:	ATP10B / 23120	HGNCID:	13543	Length:	1461	Species:	Homo sapiens

Alignment Length:	1379	Identity:	549/1379 - (39%)
Similarity:	789/1379 - (57%)	Gaps:	175/1379 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 PNHTVPPKTPKRDH------------PNG------------QFVGNKIRTTKYTLLSFIPKNLLE 272
            |:.|.|..:|::..            ||.            ::.||:..||||||.:|:|:||.|
Human    24 PSETTPLLSPEKGRQSYNLTQQRVVFPNNSIFHQDWEEVSRRYPGNRTCTTKYTLFTFLPRNLFE 88

  Fly   273 QFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCR 337
            ||||.|||||:|:|:|||:|.:..|.:|:.|:|:..||.|..:||..||.:|...||.||.:..|
Human    89 QFHRWANLYFLFLVILNWMPSMEVFHREITMLPLAIVLFVIMIKDGMEDFKRHRFDKAINCSNIR 153

  Fly   338 VYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREV 402
            :|:.:.:.|.:..|:::||||.:.:..||.||||||||.:|||.|:|:::|..||||||||:|.|
Human   154 IYERKEQTYVQKCWKDVRVGDFIQMKCNEIVPADILLLFSSDPNGICHLETASLDGETNLKQRCV 218

  Fly   403 VRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIE 467
            |:||.:.:..|.|..|.:.:..:.|...|.:|.|.:.||...|.....|.||||...::||:...
Human   219 VKGFSQQEVQFEPELFHNTIVCEKPNNHLNKFKGYMEHPDQTRTGFGCESLLLRGCTIRNTEMAV 283

  Fly   468 GIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFP-- 530
            |||:|||||||:||||||||||||::|::||||:.:|:.||:::|::||:|..:|..:|...|
Human   284 GIVIYAGHETKAMLNNSGPRYKRSKIERRMNIDIFFCIGILILMCLIGAVGHSIWNGTFEEHPPF 348

  Fly   531 -VPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQT 594
             ||....:.|.:.:...::|.|.|::|||:||:||||:|||.|:.|||.:.|::||:|.||:...
Human   349 DVPDANGSFLPSALGGFYMFLTMIILLQVLIPISLYVSIELVKLGQVFFLSNDLDLYDEETDLSI 413

  Fly   595 ECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIP 659
            :|||:||.|:|||||:||:|||||||||||:||||.:.||:|:|  .|..|....|
Human   414 QCRALNIAEDLGQIQYIFSDKTGTLTENKMVFRRCTIMGSEYSH--QENAKRLETP--------- 467

  Fly   660 NDNLNSDMAQLTQGTYLT--------PHAQRIQEFLVVLAICNTVIVGAAPHRDMMNA----SGI 712
             ..|:||..:.||...|:        |...|.|:             ||.|.|...:|    .|.
Human   468 -KELDSDGEEWTQYQCLSFSARWAQDPATMRSQK-------------GAQPLRRSQSARVPIQGH 518

  Fly   713 IEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTT---------------QPQVVSIP- 761
            ...:.:|       |.:..|..:|.|:|.....|......|               :|...|:.
Human   519 YRQRSMG-------HRESSQPPVAFSSSIEKDVTPDKNLLTKVRDAALWLETLSDSRPAKASLST 576

  Fly   762 ----ADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSL 822
                ||.::.|....||..|....     |.|  :.|:.| ||.|..:...:.:.....:|..||
Human   577 TSSIADFFLALTICNSVMVSTTTE-----PRQ--RVTIKP-SSKALGTSLEKIQQLFQKLKLLSL 633

  Fly   823 SNSISPTGRAKAVINSKI-TSIATFLNAKTQGKRMKLPSSKT------------GTIYRTADGRP 874
            |.|.|.|..:...:...: .::||..:.:.....:......|            |.|..:..|..
Human   634 SQSFSSTAPSDTDLGESLGANVATTDSDERDDASVCSGGDSTDDGGYRSSMWDQGDILESGSGTS 698

  Fly   875 L-----------------YEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILK 922
            |                 ||||||||.|||:||::|...|::|:|.|:.|.:|. |....:.:|.
Human   699 LEEALEAPATDLARPEFCYEAESPDEAALVHAAHAYSFTLVSRTPEQVTVRLPQ-GTCLTFSLLC 762

  Fly   923 VLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIM-----PVLVPCSHNSPEGI--LREQTQQLL 980
            .|.|||.||.||:|||...:.|||:|||||||.||     |..|| ..|..:.:  :|.:||:.|
Human   763 TLGFDSVRKRMSVVVRHPLTGEIVVYTKGADSVIMDLLEDPACVP-DINMEKKLRKIRARTQKHL 826

  Fly   981 DRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIED 1045
            |.|||:|||.|.:||:.::..|:..|.:..:|.|.||:||:..|.::...||:.|||||||||||
Human   827 DLYARDGLRTLCIAKKVVSEEDFRRWASFRREAEASLDNRDELLMETAQHLENQLTLLGATGIED 891

  Fly  1046 RLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFY 1110
            |||:|||:|||:|..|||.:|||||||.|||:|||:|.:|..|...:..:...:::..|:.:|..
Human   892 RLQEGVPDTIATLREAGIQLWVLTGDKQETAVNIAHSCRLLNQTDTVYTINTENQETCESILNCA 956

  Fly  1111 LTDM----ENDKTTSTLGYGQSLRKK-----------QRALVVDGKTLTFILDPKSKLILPFLRL 1160
            |.::    |..|....| :|..|..|           :..||:|||||..|.  :.||...||.|
Human   957 LEELKQFRELQKPDRKL-FGFRLPSKTPSITSEAVVPEAGLVIDGKTLNAIF--QGKLEKKFLEL 1018

  Fly  1161 SKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMA 1225
            ::.|.||||||||||||:.:||:|:::|.:.||:||||||||||||.||:|:||||||||||||:
Human  1019 TQYCRSVLCCRSTPLQKSMIVKLVRDKLRVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMS 1083

  Fly  1226 ADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLM 1290
            :||.:.||::|::|||.||:|||.||:||::|:.|||..:|.|:||||.:||||...|:|...::
Human  1084 SDFAITRFKHLKKLLLVHGHWCYSRLARMVVYYLYKNVCYVNLLFWYQFFCGFSSSTMIDYWQMI 1148

  Fly  1291 LYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVA 1355
            .:||.|||||||..||.||.::.:.||..|.|||:|:....|....||:.::||.||||:.||:.
Human  1149 FFNLFFTSLPPLVFGVLDKDISAETLLALPELYKSGQNSECYNLSTFWISMVDAFYQSLICFFIP 1213

  Fly  1356 LCAYAESDVGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSF---YLFAIVYDSV 1417
            ..||..||:.::.|||.|....|...|:|.|:|:::||:.|  .:|| ||||   :|.:::|::.
Human  1214 YLAYKGSDIDVFTFGTPINTISLTTILLHQAMEMKTWTIFH--GVVL-LGSFLMYFLVSLLYNAT 1275

  Fly  1418 CMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPR-------------LLLTTVRISLCPDD 1469
            |:.|....:.|||:....::...:||..|:.|||:|||             |:....:|...|.|
Human  1276 CVICNSPTNPYWVMEGQLSNPTFYLVCFLTPVVALLPRYFFLSLQGTCGKSLISKAQKIDKLPPD 1340

  Fly  1470 STKVILQSKRERSR 1483
            ...:.:||.|.|.|
Human  1341 KRNLEIQSWRSRQR 1354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	29/49 (59%)
		ATPase-Plipid	250..1473	CDD:273734	538/1325 (41%)
		E1-E2_ATPase	302..>394	CDD:278548	40/91 (44%)
		Cation_ATPase	<880..965	CDD:289987	44/89 (49%)
		HAD_like	<1177..1240	CDD:304363	39/62 (63%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	106/260 (41%)
ATP10B	NP_001353581.1	P-type_ATPase_APLT_Dnf-like	68..1213	CDD:319770	496/1189 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..541		14/64 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..687		4/47 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1346..1397		5/9 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	395	1.000	Domainoid score	I762
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	971	1.000	Inparanoid score	I319
Isobase	1	0.950	-	0	Normalized mean entropy	S3083
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D37083at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	1	1.000	-	-		otm42056
orthoMCL	1	0.900	-	-		OOG6_102565
Panther	1	1.100	-	-	LDO	PTHR24092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3512
SonicParanoid	1	1.000	-	-		X904
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820