Protein Alignment CG33298 and tat-1

DIOPT Version :10

• Sequence 1: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Sequence 2: NP_001255165.1
• Gene: tat-1 / 176666
• WormBaseID: WBGene00013034
• Length: 1192
• Species: Caenorhabditis elegans
• Alignment Length: 1298
• Identity: 380/1298 - (29%)
• Similarity: 608/1298 - (46%)
• Gaps: 280/1298 - (21%)

  Fly   234 HTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFG 298
            |....:.|...|.. :|..|:|.|.||...||:|:.|.|||.|..|::|:.|.||..:|::|..|
 Worm    13 HLGKVRDPHHQHAQ-RFCSNRISTCKYNGFSFLPRFLYEQFRRYNNIFFLAIALLQQIPDVSPTG 76

  Fly   299 KEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRV-YDGETERYKKVKWQELRVGDIVHL 362
            :....:|.|.:|.|:|:|::|||.:||.||.::|..:..: .||   .:.:.:|:::.|||.:.:
 Worm    77 RYTTAVPFLIILSVSALKEIFEDVKRRRSDNKVNAFSVEILVDG---HWIEKQWKDVSVGDFIRI 138

  Fly   363 SNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFVSRVEADAP 427
            .|:...|||:|||.:|:.||:.||:|.:||||||||.::.:.....|.|....|:|.|.:..:.|
 Worm   139 DNDSLFPADLLLLASSEQQGMAYIETSNLDGETNLKIKQALDITSTMTSPEKLSQFESEITCEPP 203

  Fly   428 TTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQ 492
            :..:..|:|. |...|.......:.||||.:|||||.:|.|.|:|.||::|.::|:.....|...
 Worm   204 SRHVNEFNGN-IEINGVARHFGIDQLLLRGARLKNTAWIFGAVIYTGHDSKLLMNSKRAPLKSGT 267

  Fly   493 VEQQMNIDVIWCVIILLILCVVGAIGCRMW----------LSSFTHFPVPYLPPNKLTANMESMW 547
            ::.|.|..:|:...:|:.|.::.|.|..:|          ||...|.|           ....:|
 Worm   268 IDVQTNYRIIFLFFVLVALALISATGSEIWRGNNIPQAWYLSFLEHDP-----------KGSFLW 321

  Fly   548 IFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIF 612
            ...|:.::...:||:||.||:|:.:..|..:|:|:::::|..::.....|..|:.|||||::.|.
 Worm   322 GVLTFFILYNNLIPISLQVTLEVVRFFQAIYINNDIEMYDVNSDSCAIARTSNLNEELGQVKFIM 386

  Fly   613 TDKTGTLTENKMIFRRCVVNGSDY-NHPPSELEKIYSKPGAPAPPLIPNDNLNSDMAQLTQGTYL 676
            :|||||||.|.|.|:|..:...:| |:...|.          |...:..|....|
 Worm   387 SDKTGTLTRNVMKFKRLSIGSRNYGNNEDDEF----------ADASLIEDYRQGD---------- 431

  Fly   677 TPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASSTST 741
             .|:..|.|.|.::|:|:||:
 Worm   432 -EHSTSILEVLKMMAVCHTVV-------------------------------------------- 451

  Fly   742 TTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSP 806
                                                                             
 Worm   452 ----------------------------------------------------------------- 451

  Fly   807 NSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRTAD 871
                                                                |.:|        |
 Worm   452 ----------------------------------------------------PENK--------D 456

  Fly   872 GRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDSSRKCMSIV 936
            |:.:|::.||||.|||..|.|.......|.|.:::.:  :.|.....|||.|:.|.|.||.||::
 Worm   457 GQLIYQSSSPDEAALVRGAASQSVSFHTRQPQKVICN--VFGEDETIEILDVIDFTSDRKRMSVI 519

  Fly   937 VRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYAREGLRILVMAKRTLNSA 1001
            ||.....:|.|||||||:.|...|   .|...:....|...:.|:.||..|.|.|..:.|.|...
 Worm   520 VRDGAGGDIKLYTKGADTVIFERL---EHGKEQEEAVEYCTEHLEDYASFGYRTLCFSMRHLTEQ 581

  Fly  1002 DYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVW 1066
            :|:.|...:::..::::||.:.|.|:..|||.|:.|:|||.|||:||:.|||||.:|::|.|.||
 Worm   582 EYSQWAPEYKKAILAIDNRAKLLADAAEKLERNMILVGATAIEDKLQEWVPETIQALMAADIRVW 646

  Fly  1067 VLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTDMENDKTTSTLGYGQ---- 1127
            :|||||.|||||||:|..|.....||:.:                     ||||....|.:
 Worm   647 MLTGDKRETAINIAHSCALCHTNTELLIV---------------------DKTTYEETYQKLEQF 690

  Fly  1128 -----SLRKKQR--ALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVK 1185
                 .|.|:::  |:|:|||:|...|..:::  ..|..|:.||.:|:|||.:|:|||.:|::|:
 Worm   691 VARAIELEKQEKGFAMVIDGKSLLHALTGEAR--KHFGDLALRCHAVVCCRMSPMQKAEVVEMVR 753

  Fly  1186 EELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDR 1250
            :......||||||||||:|||.|:|||||||:||:||..|:|:.:|||.:|.||||.||.|.:||
 Worm   754 KLAKHVVLAIGDGANDVAMIQAANVGVGISGEEGLQAASASDYAIPRFHFLRRLLLVHGAWNHDR 818

  Fly  1251 LSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDL 1315
            ..::|||.||||.....:..|:.::..:|||.:.::..:.::|:|||:.||:.:|::|..|..:.
 Worm   819 SVKVILYSFYKNICLYIIELWFAMFSAWSGQTIFERWTIGMFNVIFTAWPPVVLGLFDHPVPAEQ 883

  Fly  1316 LLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVALCAYAESDVGIWEFGTT-------- 1372
            ::|.|.||.:.: ..|:...:|.|.:..|:..||.:||:.. |..|..| :|:.|.|
 Worm   884 IMKYPALYASFQ-NRAFSIGNFSLWIGLAIVHSLSLFFLTY-ATMEHQV-VWDNGLTGGWLMLGN 945

  Fly  1373 -----ITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSY-WVI 1431
                 :.|:..|..|:.|    .|||...|::.:.|:|.:.:|.|||..|..:..|:.:.. .:.
 Worm   946 CAYTFVVATVCFKALLEC----DSWTWPVVVACIGSIGLWIVFVIVYSLVFPHIGGIGADMAGMA 1006

  Fly  1432 FVCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKVILQSKRERSRG--EALLVTWS 1492
            .:..:|...||.::...:..:|..|::.::.....|......::.:||..|..  |.|..:|:
 Worm  1007 AIMMSSYTFWLALLFIPLATLLWDLVIKSLFTIAMPTPRELAVMYNKRTTSFNGFERLASSWA 1069

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	342/1125 (30%)
tat-1	NP_001255165.1	P-type_ATPase_APLT_Dnf-like	30..922	CDD:319770	342/1125 (30%)
		MelB	<831..>1032	CDD:441813	51/207 (25%)