DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and tat-1

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001255165.1	Gene:	tat-1 / 176666	WormBaseID:	WBGene00013034	Length:	1192	Species:	Caenorhabditis elegans

Alignment Length:	1298	Identity:	380/1298 - (29%)
Similarity:	608/1298 - (46%)	Gaps:	280/1298 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 HTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFG 298
            |....:.|...|.. :|..|:|.|.||...||:|:.|.|||.|..|::|:.|.||..:|::|..|
Worm    13 HLGKVRDPHHQHAQ-RFCSNRISTCKYNGFSFLPRFLYEQFRRYNNIFFLAIALLQQIPDVSPTG 76

  Fly   299 KEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRV-YDGETERYKKVKWQELRVGDIVHL 362
            :....:|.|.:|.|:|:|::|||.:||.||.::|..:..: .||   .:.:.:|:::.|||.:.:
Worm    77 RYTTAVPFLIILSVSALKEIFEDVKRRRSDNKVNAFSVEILVDG---HWIEKQWKDVSVGDFIRI 138

  Fly   363 SNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFVSRVEADAP 427
            .|:...|||:|||.:|:.||:.||:|.:||||||||.::.:.....|.|....|:|.|.:..:.|
Worm   139 DNDSLFPADLLLLASSEQQGMAYIETSNLDGETNLKIKQALDITSTMTSPEKLSQFESEITCEPP 203

  Fly   428 TTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQ 492
            :..:..|:|. |...|.......:.||||.:|||||.:|.|.|:|.||::|.::|:.....|...
Worm   204 SRHVNEFNGN-IEINGVARHFGIDQLLLRGARLKNTAWIFGAVIYTGHDSKLLMNSKRAPLKSGT 267

  Fly   493 VEQQMNIDVIWCVIILLILCVVGAIGCRMW----------LSSFTHFPVPYLPPNKLTANMESMW 547
            ::.|.|..:|:...:|:.|.::.|.|..:|          ||...|.|           ....:|
Worm   268 IDVQTNYRIIFLFFVLVALALISATGSEIWRGNNIPQAWYLSFLEHDP-----------KGSFLW 321

  Fly   548 IFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIF 612
            ...|:.::...:||:||.||:|:.:..|..:|:|:::::|..::.....|..|:.|||||::.|.
Worm   322 GVLTFFILYNNLIPISLQVTLEVVRFFQAIYINNDIEMYDVNSDSCAIARTSNLNEELGQVKFIM 386

  Fly   613 TDKTGTLTENKMIFRRCVVNGSDY-NHPPSELEKIYSKPGAPAPPLIPNDNLNSDMAQLTQGTYL 676
            :|||||||.|.|.|:|..:...:| |:...|.          |...:..|....|
Worm   387 SDKTGTLTRNVMKFKRLSIGSRNYGNNEDDEF----------ADASLIEDYRQGD---------- 431

  Fly   677 TPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASSTST 741
             .|:..|.|.|.::|:|:||:
Worm   432 -EHSTSILEVLKMMAVCHTVV-------------------------------------------- 451

  Fly   742 TTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSP 806

Worm   452 ----------------------------------------------------------------- 451

  Fly   807 NSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRTAD 871
                                                                |.:|        |
Worm   452 ----------------------------------------------------PENK--------D 456

  Fly   872 GRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDSSRKCMSIV 936
            |:.:|::.||||.|||..|.|.......|.|.:::.:  :.|.....|||.|:.|.|.||.||::
Worm   457 GQLIYQSSSPDEAALVRGAASQSVSFHTRQPQKVICN--VFGEDETIEILDVIDFTSDRKRMSVI 519

  Fly   937 VRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYAREGLRILVMAKRTLNSA 1001
            ||.....:|.|||||||:.|...|   .|...:....|...:.|:.||..|.|.|..:.|.|...
Worm   520 VRDGAGGDIKLYTKGADTVIFERL---EHGKEQEEAVEYCTEHLEDYASFGYRTLCFSMRHLTEQ 581

  Fly  1002 DYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVW 1066
            :|:.|...:::..::::||.:.|.|:..|||.|:.|:|||.|||:||:.|||||.:|::|.|.||
Worm   582 EYSQWAPEYKKAILAIDNRAKLLADAAEKLERNMILVGATAIEDKLQEWVPETIQALMAADIRVW 646

  Fly  1067 VLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTDMENDKTTSTLGYGQ---- 1127
            :|||||.|||||||:|..|.....||:.:                     ||||....|.:
Worm   647 MLTGDKRETAINIAHSCALCHTNTELLIV---------------------DKTTYEETYQKLEQF 690

  Fly  1128 -----SLRKKQR--ALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVK 1185
                 .|.|:::  |:|:|||:|...|..:::  ..|..|:.||.:|:|||.:|:|||.:|::|:
Worm   691 VARAIELEKQEKGFAMVIDGKSLLHALTGEAR--KHFGDLALRCHAVVCCRMSPMQKAEVVEMVR 753

  Fly  1186 EELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDR 1250
            :......||||||||||:|||.|:|||||||:||:||..|:|:.:|||.:|.||||.||.|.:||
Worm   754 KLAKHVVLAIGDGANDVAMIQAANVGVGISGEEGLQAASASDYAIPRFHFLRRLLLVHGAWNHDR 818

  Fly  1251 LSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDL 1315
            ..::|||.||||.....:..|:.::..:|||.:.::..:.::|:|||:.||:.:|::|..|..:.
Worm   819 SVKVILYSFYKNICLYIIELWFAMFSAWSGQTIFERWTIGMFNVIFTAWPPVVLGLFDHPVPAEQ 883

  Fly  1316 LLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVALCAYAESDVGIWEFGTT-------- 1372
            ::|.|.||.:.: ..|:...:|.|.:..|:..||.:||:.. |..|..| :|:.|.|
Worm   884 IMKYPALYASFQ-NRAFSIGNFSLWIGLAIVHSLSLFFLTY-ATMEHQV-VWDNGLTGGWLMLGN 945

  Fly  1373 -----ITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSY-WVI 1431
                 :.|:..|..|:.|    .|||...|::.:.|:|.:.:|.|||..|..:..|:.:.. .:.
Worm   946 CAYTFVVATVCFKALLEC----DSWTWPVVVACIGSIGLWIVFVIVYSLVFPHIGGIGADMAGMA 1006

  Fly  1432 FVCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKVILQSKRERSRG--EALLVTWS 1492
            .:..:|...||.::...:..:|..|::.::.....|......::.:||..|..  |.|..:|:
Worm  1007 AIMMSSYTFWLALLFIPLATLLWDLVIKSLFTIAMPTPRELAVMYNKRTTSFNGFERLASSWA 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	21/49 (43%)
		ATPase-Plipid	250..1473	CDD:273734	371/1259 (29%)
		E1-E2_ATPase	302..>394	CDD:278548	35/92 (38%)
		Cation_ATPase	<880..965	CDD:289987	34/84 (40%)
		HAD_like	<1177..1240	CDD:304363	36/62 (58%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	74/258 (29%)
tat-1	NP_001255165.1	PhoLip_ATPase_N	16..79	CDD:292826	24/63 (38%)
		ATPase-Plipid	28..1036	CDD:273734	370/1247 (30%)
		E1-E2_ATPase	85..>178	CDD:278548	40/95 (42%)
		Cation_ATPase	446..545	CDD:289987	42/272 (15%)
		HAD_like	<745..789	CDD:304363	27/43 (63%)
		PhoLip_ATPase_C	791..1043	CDD:292829	74/258 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930