DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and tat-4

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001379745.1	Gene:	tat-4 / 174031	WormBaseID:	WBGene00020784	Length:	1212	Species:	Caenorhabditis elegans

Alignment Length:	1305	Identity:	465/1305 - (35%)
Similarity:	684/1305 - (52%)	Gaps:	182/1305 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 GDKFEERSYRTVVPNHTVPPKTPKRDHPN-GQFVGNKIRTTKYTLLSFIPKNLLEQFH-RVANLY 281
            |....|...|.:.|||..  ::|:.:..| ..|..|:|.|||||..:|||.|:..|.. :.||||
Worm    33 GRSNRETGSRVIRPNHLF--ESPRYELNNYRDFTDNRISTTKYTFWNFIPLNIWHQVSTKYANLY 95

  Fly   282 FIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERY 346
            ||||.:|||||...|:.:.|.:||:.||||.|.:||..||.||...|.:||..||.|:|.:...:
Worm    96 FIFIAILNWVPFFDAYTRYVGLIPICFVLGTTLIKDGIEDYRRYKFDNQINKKTCHVWDRDRCAF 160

  Fly   347 KKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREV---VRGFEE 408
            :|.:|:.:.|||.||:|||:.|||||:|||:|...|.|||:||:|||||:||:|.|   |..:.:
Worm   161 RKTEWRYILVGDFVHISNNQDVPADIILLRSSSESGTCYIETCNLDGETSLKQRMVPAKVIDYSK 225

  Fly   409 MQSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVYA 473
            ..|.|.|..|...|..:.|...:|.....:....|:...|..|.:|||.||:|||.::|||||||
Worm   226 KDSTFKPPDFTGVVTCEKPDKSIYTIRAKVEFEPGQSDVIIKENMLLRGSRIKNTTFVEGIVVYA 290

  Fly   474 GHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFPV----PYL 534
            ||:||.|.||....:|.|.:|:..|..:|.|.|:||::.:.|||...:|:.   ..||    |::
Worm   291 GHDTKVMQNNGRAPHKTSGIEKLTNKFIIACFIMLLLMVLYGAITSAVWVG---QHPVDEQIPFI 352

  Fly   535 PPNKLTANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAM 599
            ..|.....:|.......:.:..|:::|:|||:|:|:.|.||::.|.|::.|:|.::::..:||::
Worm   353 LSNTPRPFIEGFIGIGAFFINYQLLVPISLYITVEIIKALQIYFISNDIQLYDQKSDRAIDCRSL 417

  Fly   600 NITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIPNDNLN 664
            :|.||||.:.|:.:|||||||||.||||.|..:.:||....|:     |.|..|    :.:|.|.
Worm   418 SIPEELGTVTHVLSDKTGTLTENMMIFRNCAFDETDYGSNGSQ-----SNPDKP----VKSDELY 473

  Fly   665 SDMAQLTQGTYLTPHAQRIQE-FLVVLAICNTVIVGAAPHRDMM---NASGIIEVQQIGNSP-AN 724
            ..:        ||.....:|: |...:.:.|:|:|...||.|::   |..|  .|..||||. .:
Worm   474 QRI--------LTSMQNPVQKHFFANILLNNSVVVNHIPHTDVLELGNFDG--GVYNIGNSCFYD 528

  Fly   725 LKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPA------DRYIRLAESRSVTPSPPPNLL 783
            :...|.:|||.|....     .:.:...::|..:.:|.      ||...:.|..:.:.||.|
Worm   529 VTEEKYKQKLAAIGKG-----GVDDDDVSRPDELGLPTTSIQFDDRLTVIVEEDTPSDSPAP--- 585

  Fly   784 FALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLN 848
                               ::||....|:|:|          .||       |...::|:::|
Worm   586 -------------------DASPRDLPETPTP----------TSP-------IYRPLSSLSSF-- 612

  Fly   849 AKTQGKRMKLPSSKTGTIYRTADGRPL--------------------YEAESPDELALVNAAYSY 893
                       |.|..|:.|.:..||:                    |||||||||||:..|..|
Worm   613 -----------SRKLSTVVRRSILRPISDIIPVRKRLISFKQQAMNPYEAESPDELALIEGAALY 666

  Fly   894 DCCLLNRSPNQILVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQE-IVLYTKGADSSIM 957
            |..||.|:...:.:|.| ..|.:.||||..||||::||.||::|   .||: .::|.|||||:|:
Worm   667 DYVLLERAATSVTISTP-EKAEKRYEILLTLPFDATRKRMSVIV---NSQKGPLMYCKGADSAII 727

  Fly   958 PVLVPCSHNSPEGILREQTQQL---LDRYAREGLRILVMAKRTLNSADYTDWWARHQEI-EMSLE 1018
                  |..|.:.:..::.|.|   ||.||::|||.|..|.:.::..|:.|:...::.: |.:..
Worm   728 ------SRLSSDSLESKRVQDLKDHLDNYAKKGLRTLCFAMKYISKEDFEDFLDSYRFLMEDATS 786

  Fly  1019 NRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSA 1083
            .||:.|.:...:||:||.|.|.||||||||||||:|:.:|..|||.||||||||.|||.|||.|:
Worm   787 EREKMLSEKADELETNLKLSGVTGIEDRLQDGVPDTLRALRDAGIQVWVLTGDKLETAQNIATSS 851

  Fly  1084 KLFTQQMELIRLTARSRDAAETAINFYLTDMENDKTTSTLGYGQSLRKKQRALVVDGKTLTFILD 1148
            .||..|        ||....||.     ||.|....::.|.           :::....:....|
Worm   852 GLFHPQ--------RSLKVIETE-----TDAEEASESAGLN-----------IIMSPAAIRLAQD 892

  Fly  1149 PKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVG 1213
            ..:.|    :...|:..:|||.|.||.:||.:|..||:.:....||||||||||.|||.|.||:|
Worm   893 GNAHL----MEALKKAKTVLCYRMTPSEKATIVNTVKKRIKGNVLAIGDGANDVPMIQAAHVGIG 953

  Fly  1214 ISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGF 1278
            |:|:||:||.||.||.:.||::|.||||.||:|.|.||:...|||.||||..||:||:||.|.|.
Worm   954 IAGKEGLQAAMACDFAIARFKFLSRLLLVHGHWSYYRLANTFLYFLYKNANAVFIIFYYQFYNGA 1018

  Fly  1279 SGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLD 1343
            ||..::|.::.::|.:||||:.|:.:||.|:...:..|:..|.||..||....|....|:..::|
Worm  1019 SGTNIVDPIWGVIYPIIFTSVQPVVVGVLDQDYDDQTLMNKPELYVIGRENQLYTWKHFFRDVID 1083

  Fly  1344 ALYQSLVIFFVALCAYAESDVGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFY 1408
            .:||:.||::||......|...:||.|..|..|.:..|..|.|:::|.|   |..  :::|.||:
Worm  1084 GIYQAAVIYYVAYLTLDNSTSSLWEMGFYIATSSILVNSGHLALQVRYW---HWQ--LVALFSFF 1143

  Fly  1409 L---FAIVYDSVCMNCFGVR---SSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCP 1467
            :   ||..: :.|:......   ...|:..........|....::.:||:.||.      .|:|.
Worm  1144 ILFNFAFFF-AECLTAAAAMVPDPPVWMPIHAMGDPRFWYYQFITVIVALCPRF------TSMCL 1201

  Fly  1468 DDSTK 1472
            ..|.|
Worm  1202 MSSLK 1206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	27/50 (54%)
		ATPase-Plipid	250..1473	CDD:273734	457/1273 (36%)
		E1-E2_ATPase	302..>394	CDD:278548	47/91 (52%)
		Cation_ATPase	<880..965	CDD:289987	38/85 (45%)
		HAD_like	<1177..1240	CDD:304363	36/62 (58%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	85/250 (34%)
tat-4	NP_001379745.1	P-type_ATPase_APLT_Dnf-like	65..1095	CDD:319770	426/1146 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I6325
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D37083at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	1	1.000	-	-		otm14244
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.030