DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and Atp10a

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_033858.2	Gene:	Atp10a / 11982	MGIID:	1330809	Length:	1508	Species:	Mus musculus

Alignment Length:	1415	Identity:	582/1415 - (41%)
Similarity:	808/1415 - (57%)	Gaps:	216/1415 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 KEEPAREPSAPTSATGGRGHSRQASRSESIYTLRRTEAPPWWKRLTLCNYNTGDKFEERSYRTVV 231
            :|.||.|.||   ::|.|...|           ||      |:..|               |||.
Mouse     3 RELPAAEESA---SSGWRRPRR-----------RR------WEGRT---------------RTVR 32

  Fly   232 PNHTVPP---KTPKRDHPNGQ----------FVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFI 283
            .| .:||   :......|.|:          ...|:::|||||||||:||||.|||||:||:||:
Mouse    33 SN-LLPPLGTEDSTIGAPKGERLLMRGCIQHLADNRLKTTKYTLLSFLPKNLFEQFHRLANVYFV 96

  Fly   284 FIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKK 348
            ||.|||:||.::||...:|:.||||:|.|||:|||:||..|..||..||:..|.|:..|.::|..
Mouse    97 FIALLNFVPAVNAFQPGLALAPVLFILAVTAIKDLWEDYSRHRSDHEINHLGCLVFSREEKKYVN 161

  Fly   349 VKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIF 413
            ..|:|:||||.|.|..||.:|||||||.:|||.|:|:|:|.:||||||||||:|||||.|:.|.|
Mouse   162 RYWKEIRVGDFVRLCCNEIIPADILLLSSSDPDGLCHIETANLDGETNLKRRQVVRGFSELVSEF 226

  Fly   414 VPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETK 478
            .|..|.|.:|.:.|...|.||.|.::|..||:..:..|.||||...::||:.:.|||:|||||||
Mouse   227 NPLTFTSVIECEKPNNDLSRFRGYIMHSNGEKAGLHKENLLLRGCTIRNTEAVAGIVIYAGHETK 291

  Fly   479 SMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTH----FPVPYLPPNKL 539
            ::||||||||||||:|:|||.||:|||::|:.:.:..|:|..:|:..:..    |.||....:.|
Mouse   292 ALLNNSGPRYKRSQLERQMNCDVLWCVLLLVCISLFSAVGHGLWVRRYQEKKALFDVPESDGSSL 356

  Fly   540 TANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEE 604
            :....:::.|:|.|::|||:||:||||:||:.|:.||:.|:.:::|:|.||:.|.:|||:||||:
Mouse   357 SPATAAVYSFFTMIIVLQVLIPISLYVSIEIVKVCQVYFINQDIELYDEETDSQLQCRALNITED 421

  Fly   605 LGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNH------------PPSELEKIYSKPG------ 651
            ||||::||:|||||||||||:||||.|:|.:|:|            ..||.|::.||.|
Mouse   422 LGQIKYIFSDKTGTLTENKMVFRRCTVSGIEYSHDANAQRLARYQEADSEEEEVVSKVGTISHRG 486

  Fly   652 ---------------------------------------APAPP----LIPNDNLNSDMAQLTQG 673
                                                   |.:.|    :.|:..|...:::..:.
Mouse   487 STGSHQSIWMTHKTQSIKSHRRTGSRAEAKRASMLSKHTAFSSPMEKDITPDPKLLEKVSECDRF 551

  Fly   674 -----------TYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKH 727
                       .:|:|....:.:|.:.|.|||||:|                     .||
Mouse   552 LAIARHQEHPLAHLSPELSDVFDFFIALTICNTVVV---------------------TSP----- 590

  Fly   728 GKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQ 792
            .:.|||:.......:...||               :.::     |..|||         ...|..
Mouse   591 DQPRQKVRVRFELKSPVKTI---------------EDFL-----RRFTPS---------RLASGC 626

  Fly   793 PTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMK 857
            .::..:|:|..|..:..:..|       |||......| .:..:.....|||:...|...|:...
Mouse   627 SSIGNLSTSKSSHKSGSAFLP-------SLSQDSMLLG-LEEKLGQTAPSIASNGYASQAGQEES 683

  Fly   858 LPSSKT------GTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATR 916
            ..|..|      |......:|...||||||||.|||.||.:|:|.|::|..:|:.|.:|..|..
Mouse   684 WASECTTDQKCPGEQREQQEGELRYEAESPDEAALVYAARAYNCALVDRLHDQVSVELPHLGRL- 747

  Fly   917 EYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEG----ILREQTQ 977
            .:|:|..|.|||.||.||:|:|...:.||.:|||||||.:|.:|:|||.:...|    .:|.:||
Mouse   748 TFELLHTLGFDSIRKRMSVVIRHPLTDEINVYTKGADSVVMDLLLPCSSDDARGRHQKKIRSKTQ 812

  Fly   978 QLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATG 1042
            ..|:.||.||||.|.:|||.|:..:|..|...|.|.|.|:|:||..|..|..:||:||.||||||
Mouse   813 NYLNLYAVEGLRTLCIAKRVLSKEEYACWLQSHIEAEASVESREELLFQSAVRLETNLHLLGATG 877

  Fly  1043 IEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAI 1107
            ||||||:|||||||.|..||:.:|||||||.||||||||:.||.....|:|.|.|.|::|....:
Mouse   878 IEDRLQEGVPETIAKLRQAGLQIWVLTGDKQETAINIAYACKLLDHGEEVITLNADSQEACAALL 942

  Fly  1108 NFYLTDMENDKTTSTLGYGQSL---------------RKKQRALVVDGKTLTFILDPKSKLILPF 1157
            :..|:.:::....|||...:|.               .....:||:||::|.:.|:  ..|...|
Mouse   943 DQCLSYVQSRNPRSTLQNSESNLSVGFSFNPVSTSTDASPSPSLVIDGRSLAYALE--KSLEDKF 1005

  Fly  1158 LRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQA 1222
            |.|:|:|.||||||||||||:.:||:|:.:|...|||||||||||||||:|||||||||||||||
Mouse  1006 LFLAKQCRSVLCCRSTPLQKSMVVKLVRSKLKAMTLAIGDGANDVSMIQVADVGVGISGQEGMQA 1070

  Fly  1223 VMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQM 1287
            |||:||.:||||||||||:.||:|||.||:.|:|||||||..||.|:||:|.|||||...|:||.
Mouse  1071 VMASDFAVPRFRYLERLLIVHGHWCYSRLANMVLYFFYKNTMFVGLLFWFQFYCGFSASAMIDQW 1135

  Fly  1288 YLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIF 1352
            ||:.:||:|:|||.|..||.||.|..|:||:.|.|||:|:....|||..|||.::||.:||||.|
Mouse  1136 YLIFFNLLFSSLPQLVTGVLDKDVPADMLLREPQLYKSGQNMEEYRPRAFWLNMVDAAFQSLVCF 1200

  Fly  1353 FVALCAYAESDVGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSV 1417
            |:...||.:|||.::.:||.:||..||..|:|..||.::||.|:.|:...|...|:..|::|::.
Mouse  1201 FIPYLAYYDSDVDVFTWGTPVTAIALFTFLLHLGIETKTWTWLNWLACGFSTFLFFSVALIYNTS 1265

  Fly  1418 CMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCP 1467
            |..|:...:.||.:.......:.:|..:::.:.|:||||....::.||.|
Mouse  1266 CATCYPPSNPYWTMQTLLGDPLFYLTCLIAPIAALLPRLFFKALQGSLFP 1315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	32/59 (54%)
		ATPase-Plipid	250..1473	CDD:273734	561/1319 (43%)
		E1-E2_ATPase	302..>394	CDD:278548	49/91 (54%)
		Cation_ATPase	<880..965	CDD:289987	42/84 (50%)
		HAD_like	<1177..1240	CDD:304363	48/62 (77%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	116/245 (47%)
Atp10a	NP_033858.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		9/33 (27%)
		P-type_ATPase_APLT_Dnf-like	65..1203	CDD:319770	525/1203 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..705		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1334..1354
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1407..1436
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1481..1508
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	406	1.000	Domainoid score	I706
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	992	1.000	Inparanoid score	I307
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D37083at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	1	1.000	-	-		otm44111
orthoMCL	1	0.900	-	-		OOG6_102565
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3512
SonicParanoid	1	1.000	-	-		X904
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870