Protein Alignment CG33298 and atp8a2

DIOPT Version :10

• Sequence 1: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Sequence 2: XP_012813389.2
• Gene: atp8a2 / 101730757
• XenbaseID: XB-GENE-6036032
• Length: 1197
• Species: Xenopus tropicalis
• Alignment Length: 1326
• Identity: 409/1326 - (30%)
• Similarity: 638/1326 - (48%)
• Gaps: 279/1326 - (21%)

  Fly   249 QFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVT 313
            :|..|.:.|.||::|:|:|:.|.||..|.||.:|:||.||..:|::|..|:...::|::|:|.|.
 Frog    77 KFRDNTVSTAKYSVLTFLPRFLYEQIRRAANAFFLFIALLQQIPDVSPTGRYTTLVPLIFILTVA 141

  Fly   314 AVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTS 378
            .:|::.||.:|..:|..:|.....|..|.|  ::.:.|:|:.|||||.::|.:.:|||:::|.:|
 Frog   142 GIKEIIEDYKRHKADNTVNKKKTIVLKGGT--WQNMVWREVAVGDIVKVTNGQHLPADMIILSSS 204

  Fly   379 DPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTG 443
            :||.:|||:|.:||||||||.|:.:.....:.|.....|...|:|.:.|...||.|.|.|...|.
 Frog   205 EPQAMCYIETSNLDGETNLKIRQGLPATSNLLSEEDLVKMTGRIECEGPNRHLYDFIGNLRLGTN 269

  Fly   444 ERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIIL 508
            ..||:..|.:|||.::::||.::.|||||.||:||.|.|::....|||.||:..|:.::....||
 Frog   270 NPVPVGPEQILLRGAQIRNTQWVIGIVVYTGHDTKLMQNSTKAPLKRSNVEKVTNVQILVLFGIL 334

  Fly   509 LILCVVGAIGCRMWLSSFTHFPVPYLPPNKLTANMESM-----WIFWTYIVILQVMIPLSLYVTI 568
            |::.:|.::|..:|       ...|...|....:::::     :...|:|::...:||:||.||:
 Frog   335 LVMALVSSVGALLW-------NWKYEGTNWYLGDIDAVSTNFGYNLLTFIILYNNLIPISLLVTL 392

  Fly   569 ELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNG 633
            |:.|..|...|:.:.|::.:||:.....|..|:.|||||::::|:|||||||.|.|.|::|.:.|
 Frog   393 EVVKFTQALFINWDRDMYYSETDTPAMARTSNLNEELGQVKYLFSDKTGTLTCNVMHFKKCSIGG 457

  Fly   634 SDYNHPPSELEKIYSKPGAPAPPLIPNDNLNSDMAQLTQGTYL-TPHAQRIQEFLVVLAICNTVI 697
            ..|.|.| |.|:..|.......| ..:::.:.|..:|.|.... :|....|:|||.:||:|:||:
 Frog   458 ITYGHFP-EFERERSSEDFSQLP-TTSESCDFDDPKLFQNIENDSPTGDTIKEFLTLLAVCHTVV 520

  Fly   698 VGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPA 762
                |.:|                                      ..|||
 Frog   521 ----PEKD--------------------------------------EDTII-------------- 529

  Fly   763 DRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSIS 827
                                                                             
 Frog   530 ----------------------------------------------------------------- 529

  Fly   828 PTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYS 892
                                                            |:|.||||.|||..|..
 Frog   530 ------------------------------------------------YQASSPDEGALVKGARK 546

  Fly   893 YDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIM 957
            .......|:|:.:::.  ..|..:.:|:|.||.|.|:||.||::|| ..|..:.||.||||:.|.
 Frog   547 LGYTFTGRTPDSVIID--AMGKEQSFELLNVLEFSSNRKRMSVIVR-TPSGNLRLYCKGADNVIF 608

  Fly   958 PVLVPCSHNSPEGILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRER 1022
            ..|      |.|....|||...|:::|.||||.|.:|...|..::|..|...|.|..:.:::|.:
 Frog   609 ERL------SRESKYMEQTLNHLEQFASEGLRTLCLAYCDLQDSEYEAWLNVHSEASVVIKDRAQ 667

  Fly  1023 RLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFT 1087
            :|.:.:..:|.:|.|||||.||||||.|||||||:|:.|.|.:|||||||.|||:||.||.:|.:
 Frog   668 KLEECYEIIEKDLMLLGATAIEDRLQGGVPETIATLMKAEIKIWVLTGDKQETAVNIGYSCRLVS 732

  Fly  1088 QQMELIRLTARSRDAAETAINFYLTDMENDKTTSTLGYGQSLRKKQRALVVDGKTLTFILDPKSK 1152
            |.|.||.:...|.||..:.:..:.|::.:       |.|   ::...||::||:||.:.|  ..:
 Frog   733 QTMSLIVVNEDSLDATRSTLTNHCTNLGD-------GLG---KENDLALIIDGQTLKYAL--SFE 785

  Fly  1153 LILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQ 1217
            :...||.|:..|.:|:|||.:||||:.:|.:||:.:|..|||||||||||.|||.|.|||||||.
 Frog   786 VRQSFLDLALSCKAVICCRVSPLQKSEIVDMVKKHVNAITLAIGDGANDVGMIQTAHVGVGISGN 850

  Fly  1218 EGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQV 1282
            |||||...:|:.:.:|.|||:|||.||.|.|:|:::.|||.||||.....:..|:.:..||||||
 Frog   851 EGMQATNNSDYAIAQFCYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFAVVNGFSGQV 915

  Fly  1283 MMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQ 1347
            :.::..:.|||:|||:|||..:|:.::..::|.:|:.|.|||..:....:....||...::||..
 Frog   916 LFERWCIGLYNVIFTALPPFTLGICERSCSQDSMLRFPQLYKITQNADGFNTRVFWGHCINALIH 980

  Fly  1348 SLVIFFVALCAYAESD-------------VGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLS 1399
            |:::|:..| ...|.|             ||...:...:...||.|.|     |..:||....|:
 Frog   981 SIILFWFPL-KMLEHDAVFTNGQVTDYLFVGNIVYTYVVVTVCLKAGL-----ETTAWTKFSHLA 1039

  Fly  1400 IVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIF-----------VCFASAVHWLVIMLSTVVAVL 1453
            :   .||..::.:.        ||..|:.|...           :...|...||.::|.....:|
 Frog  1040 V---WGSMLMWLVF--------FGAYSAIWPTIPIAPDMLGQAGMVLTSGYFWLGLLLVPTACLL 1093

  Fly  1454 ------------PRLLLTTVR-ISLCPDDSTKVILQSKRERSRGEA--LLVTWSRST-----SAS 1498
                        .:.||..|: |.....:.:|..::....:|..|.  ||....|.|     .|:
 Frog  1094 RDVTWRAAKHTYHKTLLEQVQEIETRAKEMSKAAMRDSNGKSLNERDHLLRRLGRKTPPSLFRAN 1158

  Fly  1499 SIYRITDYG-----------SKNQII 1513
            |:.:...||           |::|::
 Frog  1159 SVQQSVSYGYAFSQEEHGVVSQSQVV 1184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	367/1108 (33%)
atp8a2	XP_012813389.2	ATPase-Plipid	78..1115	CDD:273734	395/1254 (31%)