DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and ATP9A

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_006036.1	Gene:	ATP9A / 10079	HGNCID:	13540	Length:	1047	Species:	Homo sapiens

Alignment Length:	1272	Identity:	345/1272 - (27%)
Similarity:	549/1272 - (43%)	Gaps:	300/1272 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 PKTPKRDHP---NGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGK 299
            |:|....||   :.::..|.|...||...:|:|..|..||....||||:.:....:|||:.....
Human    38 PRTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGAL 102

  Fly   300 EVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETER-YKKVKWQELRVGDIVHLS 363
            ....:|:.|||.||.:::..|:.|....||.:|:   :||...|.| ..|||...::|||::.:.
Human   103 YTYWVPLGFVLAVTVIREAVEEIRCYVRDKEVNS---QVYSRLTARGTVKVKSSNIQVGDLIIVE 164

  Fly   364 NNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFVSRVEADAPT 428
            .|:.||||::.||||:..|.|::.|..|||||:.|.|..|...:.:.:.....:..|.|.|:.|.
Human   165 KNQRVPADMIFLRTSEKNGSCFLRTDQLDGETDWKLRLPVACTQRLPTAADLLQIRSYVYAEEPN 229

  Fly   429 TKLYRFHGALIHPTGERVPISTECLLLRESRLKNT----DYIEGIVVYAGHETKSMLNNSGPRYK 489
            ..::.|.|.......: .||| |.|.:..:....|    ..:.|:|:|.|.|.:|::|.|.||.|
Human   230 IDIHNFVGTFTREDSD-PPIS-ESLSIENTLWAGTVVASGTVVGVVLYTGRELRSVMNTSNPRSK 292

  Fly   490 RSQVEQQMNIDVIWCVIILLI--LCVVGAIGCRMWLSSFTHFPVPYLPPNKLTANMESMWIFW-- 550
            ....:.::|     |:..:|.  |.||..:     :.:..||              ...|...
Human   293 IGLFDLEVN-----CLTKILFGALVVVSLV-----MVALQHF--------------AGRWYLQII 333

  Fly   551 TYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDK 615
            .::::...:||:||.|.:::.||:..:.|..:..:      ..|..|:..|.|:||:|.::.|||
Human   334 RFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKI------PGTVVRSSTIPEQLGRISYLLTDK 392

  Fly   616 TGTLTENKMIFRR----CVVNGSD-YNHPPSELEKIYSKPGAPAPPLIPNDNLNSDMAQLTQGTY 675
            |||||:|:|||:|    .|..|.| .:...|.:..||::.....|            ||  :|..
Human   393 TGTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPP------------AQ--KGPT 443

  Fly   676 LTPH-----AQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLL 735
            ||..     :.|:.|.:..:|:|:.|
Human   444 LTTKVRRTMSSRVHEAVKAIALCHNV--------------------------------------- 469

  Fly   736 ASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISS 800
                   |.....||.|.|
Human   470 -------TPVYESNGVTDQ---------------------------------------------- 481

  Fly   801 SAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKTGT 865
             ||:....|
Human   482 -AEAEKQYE-------------------------------------------------------- 489

  Fly   866 IYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDSSR 930
                 |...:|:|.||||:|||....|....|:.|..:.:.:..| ......:.||::.||....
Human   490 -----DSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTP-GDQILNFTILQIFPFTYES 548

  Fly   931 KCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYAREGLRILVMAK 995
            |.|.|:||...:.||..|.|||| .:|..:|  .:|.   .|.|:...:    ||||||:||:||
Human   549 KRMGIIVRDESTGEITFYMKGAD-VVMAGIV--QYND---WLEEECGNM----AREGLRVLVVAK 603

  Fly   996 RTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLS 1060
            ::|....|.|:.||:.:.::|:.:|..::......||..:.||..||:||:||..|..|:.:|.:
Human   604 KSLAEEQYQDFEARYVQAKLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVRPTLETLRN 668

  Fly  1061 AGISVWVLTGDKPETAINIAYSAKLFT--QQMELIRLTARSRDAAETAINFYLTDMENDKTTSTL 1123
            |||.||:|||||.|||...|.:|.|.|  |.:.:.||.. :|..|...:|.:
Human   669 AGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFRLVT-NRGEAHLELNAF------------- 719

  Fly  1124 GYGQSLRKKQRALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEEL 1188
                 .||...|||:.|.:|...|   ......|:.|:.:|.:|:|||..|.|||.:|::::|..
Human   720 -----RRKHDCALVISGDSLEVCL---KYYEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERT 776

  Fly  1189 NLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSR 1253
            ...|.|:|||.|||||||.:|.|||:.|:||.||.:||||::.:|::|.|||:.||...|.|.:.
Human   777 GKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSAA 841

  Fly  1254 MILYFFYKN-------AAF--VFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDK 1309
            :..:..:::       |.|  ||......||.||         .::.|:.|:|..|..:: |.||
Human   842 LSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGF---------LIIGYSTIYTMFPVFSL-VLDK 896

  Fly  1310 RVAEDLLLKNPYLYKN---GRLGVAYRPHDFWLILLDALYQSLVIFFVALCAYAESDVGIWEFGT 1371
            .|..::.:..|.|||:   || .::|:....|:::  ::||...|.:.||..:....|.|.....
Human   897 DVKSEVAMLYPELYKDLLKGR-PLSYKTFLIWVLI--SIYQGSTIMYGALLLFESEFVHIVAISF 958

  Fly  1372 TITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFA 1436
            |   |.:...|:..|:.|::|..|..::.:||| :.|:.::|:         :.....|.|:...
Human   959 T---SLILTELLMVALTIQTWHWLMTVAELLSL-ACYIASLVF---------LHEFIDVYFIATL 1010

  Fly  1437 SAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKV 1473
            |.: |.|.:: |:|:.||..:|..:|....|...:|:
Human  1011 SFL-WKVSVI-TLVSCLPLYVLKYLRRRFSPPSYSKL 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	16/49 (33%)
		ATPase-Plipid	250..1473	CDD:273734	340/1255 (27%)
		E1-E2_ATPase	302..>394	CDD:278548	35/92 (38%)
		Cation_ATPase	<880..965	CDD:289987	29/84 (35%)
		HAD_like	<1177..1240	CDD:304363	32/62 (52%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	67/256 (26%)
ATP9A	NP_006036.1	P-type_ATPase_APLT_Neo1-like	55..967	CDD:319841	318/1163 (27%)
ATP9A	NP_006036.1	Cation_ATPase	464..571	CDD:404183	39/261 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930