DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and atp8b3

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_031760429.1	Gene:	atp8b3 / 100490666	XenbaseID:	XB-GENE-992174	Length:	1181	Species:	Xenopus tropicalis

Alignment Length:	1354	Identity:	412/1354 - (30%)
Similarity:	638/1354 - (47%)	Gaps:	336/1354 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 NHTVPPKT----PKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPE 293
            |.:|..||    .|:     ::..|.|.|:||.:|:|||.:|.|||||:|||||:||::|..:|.
Frog    32 NSSVKKKTWLFFKKK-----KYASNSITTSKYNILTFIPLSLFEQFHRMANLYFLFIIILQTIPA 91

  Fly   294 ISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGD 358
            ||.......|:|:||:|.:..::||.:|..|..|||.|||..|.:..|::  :...||::::.||
Frog    92 ISTLPWFAIMLPLLFLLVIRGIRDLIDDIVRHRSDKAINNRPCEILKGQS--FCMEKWKDIQTGD 154

  Fly   359 IVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVV----RGFEEMQSIFVPSKFV 419
            ||.:..|:.||||:.||::|:|..:||::|.|:|||||||.::.:    :|....:|:   |.||
Frog   155 IVRIQKNDYVPADLFLLKSSEPSSLCYVETADIDGETNLKFKQALMVTHQGLSTEESL---SNFV 216

  Fly   420 SRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNS 484
            .:|..:.|.:.::.|.|.| ...||:.|:..:|:|||..|::||:...|:|:|||.:||.|.|..
Frog   217 GKVICEEPNSNMHTFIGTL-EWNGEKYPLDNDCILLRGCRIRNTETCYGLVIYAGFDTKIMRNGG 280

  Fly   485 GPRYKRSQVEQQMNIDVIWCVIILLILCVVGAI--GCR-MWLSSFTHFPVPYLPPNKLTANMESM 546
            ..|.|::::|:.|||.||....:|:|...|.||  |.| .|... .|..:|.|..|. |....:.
Frog   281 KVRVKKTKLEKMMNILVIIIFGMLIICAAVLAIIAGYRSAWFKG-KHSYIPPLAEND-TPAYTAF 343

  Fly   547 WIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHI 611
            .:||.|:::|..::|:|:|:|:||..::....|:.:.|::..:.|.....|:.::.:.|||::::
Frog   344 LVFWGYVILLSTIVPMSMYITLELIHLIHNMFINWDEDMYSTKKNTAANARSSSLNDVLGQVEYV 408

  Fly   612 FTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIPNDNLNSDMAQLTQGTYL 676
            |:|||||||:|.|.|::|.:||           |.|.|..        .|..|:::...:...|.
Frog   409 FSDKTGTLTQNIMTFKKCCING-----------KTYGKSS--------KDEENNEVVNFSWNKYA 454

  Fly   677 TPHAQ----------------RIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANL 725
            ..:.|                ..:||..|||:|:||:|
Frog   455 DKNFQFYDQSLLDMVCENKDGVYREFFRVLALCHTVMV--------------------------- 492

  Fly   726 KHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQS 790
                :|                 ||
Frog   493 ----ER-----------------NG---------------------------------------- 496

  Fly   791 HQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKR 855

Frog   497 ----------------------------------------------------------------- 496

  Fly   856 MKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEI 920
                            |..:|:|.||||.|||.||.:.....|:|:.:.:.|:  ..|..|.|.:
Frog   497 ----------------GEIIYKAASPDEEALVTAARNVGYVFLSRTQDTMTVN--ELGEERTYRV 543

  Fly   921 LKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVL-VPCSHNSPEGILREQTQQLLDRYA 984
            |..|.|.|.||.|||:|:. ...:|.|||||||..|:..| ..||.       .|.|::.|..:|
Frog   544 LAFLDFSSVRKRMSILVKD-PDGKIKLYTKGADDVILRRLHSECSS-------YEITEKALAMFA 600

  Fly   985 REGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQD 1049
            .:.||.|.:|.:.::...||.|..|:.:..::|:||...|...:.:||::|.|||||.|||:|||
Frog   601 HDTLRTLCVACKDVDIPVYTAWSKRYHQASVTLQNRTALLERVYDELETDLQLLGATAIEDKLQD 665

  Fly  1050 GVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTD- 1113
            .|||||..|....:.||||||||.||||||.:|.:|.:..||::         .|..|:..|.:
Frog   666 KVPETIQLLKDGNMKVWVLTGDKQETAINIGFSCRLLSDDMEIL---------DEEQISDILDEY 721

  Fly  1114 MENDKTTSTLGYGQ-------------SLRKKQRALVVDGKTLTFILDPK----SKLIL------ 1155
            .|::...|  |.||             ||:.::.||||.|..|..||..|    .||:|
Frog   722 WEHNNNVS--GSGQDLVGSNSFKKHRASLQGRKMALVVSGDFLDRILGTKIQKQGKLLLLRKCFN 784

  Fly  1156 ---------------PFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMI 1205
                           .|:.|:.:|.:|:|||.||.||:.:|::||:.....|||||||||||:||
Frog   785 WKRNQNKQEDSLKEWAFVDLASQCQTVICCRVTPKQKSMVVQLVKKHKRATTLAIGDGANDVNMI 849

  Fly  1206 QMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIF 1270
            :.||:||||||.||.|||.::||::.:|.:|:|||..||.|.|.|:::...|||||..|.|....
Frog   850 KTADIGVGISGLEGTQAVQSSDFSIAQFCFLQRLLFIHGRWSYLRITKFFKYFFYKTFANVLGHV 914

  Fly  1271 WYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPH 1335
            |:..:.||:...:.|..|:.||.::|||.|.|::.|.::.|..::.|.:|.||:.|:.|..:...
Frog   915 WFGFFNGFTALTLYDSWYISLYAIMFTSFPVLSLAVLEQDVTAEISLLSPELYRVGQSGSLFTYK 979

  Fly  1336 DFWLILLDALYQSLVIFFVALCAYAES--DVGIWE---FGTTITASCLFANLVHCAIEIRSWTVL 1395
            .|....|..:..||..||::...:.::  ..||.:   |..|...:.:.:..:....||..||.|
Frog   980 TFLGSFLKGIATSLSSFFISFGTFQDTAGPSGICDYQAFAVTTATTVILSVTLEITFEISYWTRL 1044

  Fly  1396 HVLSIVLS-----LGSFY-----LFAIV-----YDSVCMNCFGVRSSYWVIFVCFASAVHWLVIM 1445
            .|:::|:|     |.||.     ||..:     :..|..|..    |:..|         ||.|:
Frog  1045 SVIAVVISPLLYFLSSFTSQAFPLFVFLPTMFQFPGVSRNAL----SHGYI---------WLTII 1096

  Fly  1446 LSTVVAVLPRLLLTTVRISLCPDDSTKVILQSKRERSRGEALLVTWSRSTSASS 1499
            |..|:::||.|::.     .|    ||::.:::...:.|..     :.:||||:
Frog  1097 LGVVISILPSLVMI-----FC----TKLMSRNQIHSNMGSK-----ADTTSASN 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	26/49 (53%)
		ATPase-Plipid	250..1473	CDD:273734	401/1305 (31%)
		E1-E2_ATPase	302..>394	CDD:278548	37/91 (41%)
		Cation_ATPase	<880..965	CDD:289987	36/85 (42%)
		HAD_like	<1177..1240	CDD:304363	35/62 (56%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	76/264 (29%)
atp8b3	XP_031760429.1	P-type_ATPase_APLT_Dnf-like	50..999	CDD:319770	370/1165 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930