DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and atp8b5a

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_021332106.1	Gene:	atp8b5a / 100330945	ZFINID:	ZDB-GENE-060531-48	Length:	1205	Species:	Danio rerio

Alignment Length:	1306	Identity:	409/1306 - (31%)
Similarity:	636/1306 - (48%)	Gaps:	246/1306 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 QFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVT 313
            ::..|.|:|:||...||:|.||.|||.|:||.||:|:::|..:|.||:......::|::.||.||
Zfish    32 KYATNCIKTSKYNPFSFLPLNLFEQFQRIANAYFLFLLILQVIPAISSLSWFTTVVPLVLVLSVT 96

  Fly   314 AVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTS 378
            |.||..:|..|..||:::||....|.  .:.:....||..::||||:.|.||:.|.||:|||.:|
Zfish    97 AAKDAIDDINRHRSDRQVNNRKVNVL--ISGKLTSEKWMNVQVGDIIKLENNQFVTADLLLLSSS 159

  Fly   379 DPQGVCYIDTCDLDGETNLKRREVVRGFEEM-QSIFVPSKFVSRVEADAPTTKLYRFHGALIHPT 442
            :|..:.||:|.:||||||||.::.:....:| .::...:.|...|..:.|..:|.||.|.|...|
Zfish   160 EPLNLVYIETAELDGETNLKVKQSLTVTGDMGHNLEALAAFNGEVCCEPPNNRLDRFTGTLTFDT 224

  Fly   443 GERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVII 507
             ::..:..|.:|||...|:|||:..|:|::||.|||.|.|.....:||:.:::.||:.|::...:
Zfish   225 -QKYSLDNERVLLRGCTLRNTDWCFGLVLFAGPETKLMQNCGKSTFKRTSIDRLMNVLVLFIFAL 288

  Fly   508 LLILCVVGAIGCRMWLSSFTHFPVPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLYVTIELCK 572
            |.::|::.|:|..:| .::|........|::..|...:...||:||:||..::|:||||::|:.:
Zfish   289 LALMCIILAVGHGIW-ENYTGSKFNVFLPHEENAAFSAFLTFWSYIIILNTVVPISLYVSMEVIR 352

  Fly   573 ILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDY- 636
            :...::|:.:.:::...|:...|.|...:.||||||::||:|||||||:|.|.|.:|.:||..|
Zfish   353 LGNSYYINWDRNMYHTRTDTPAEARTTTLNEELGQIKYIFSDKTGTLTQNIMTFNKCSINGKSYG 417

  Fly   637 ---NHPPSELEKI--------YSKPGAPAPPLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVL 690
               .|...:..:|        :|..|...|..:..|:...:..:|        ....:..|..:|
Zfish   418 DVFQHYSGQTLEITEETTPVDFSFNGLADPKFLFYDHSLVEAVKL--------ELPEVHAFFRLL 474

  Fly   691 AICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQP 755
            |:|:|.
Zfish   475 ALCHTC----------------------------------------------------------- 480

  Fly   756 QVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNK 820
                        :||.:.
Zfish   481 ------------MAEEKK----------------------------------------------- 486

  Fly   821 SLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELA 885
                                                              :|..:|:|:||||.|
Zfish   487 --------------------------------------------------EGHLVYQAQSPDEGA 501

  Fly   886 LVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTK 950
            ||.||.::.....:|||..|.:.  ..|..|.||:|.:|.|::.||.||::||. ...::.||.|
Zfish   502 LVTAARNFGFVFRSRSPETITIE--EMGIQRTYELLAILDFNNVRKRMSVIVRN-PEGKLSLYCK 563

  Fly   951 GADSSIMPVLVP-CSHNSPEGILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIE 1014
            |||:.|...|.| ||.      |.|.|.:.|:.:|.||||.||:|.:.|:...:.:|..||.|..
Zfish   564 GADTIIYERLHPSCSK------LMEVTTEHLNEFAGEGLRTLVLAYKDLDEDYFAEWKQRHHESS 622

  Fly  1015 MSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINI 1079
            :::|:||.:|...:.::|.::.|:|||.|||:|||||..||..|..|.|.:|||||||.|||.||
Zfish   623 VAMEDREEKLDKVYEEIEKDMMLIGATAIEDKLQDGVALTIELLAKAEIKIWVLTGDKQETAENI 687

  Fly  1080 AYSAKLFTQQM-ELIRLTARSRDAAETAINFYLTDM----ENDK---TTSTLGYGQSLRKKQR-- 1134
            .||..|..::| ::..:.|.|.:.....:......|    |.||   ....||....:.:.:.
Zfish   688 GYSCNLLREEMNDVFIVAAHSPEEVRQELRDARLKMQPSTEQDKFLIPEVILGNTPKVVQDEHVN 752

  Fly  1135 ---ALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIG 1196
               .||::|.:|.|.|:  |.:.|.|||.:..|.:|:|||.||||||.:|::||......|||||
Zfish   753 GEYGLVINGHSLAFALE--SSMELEFLRTACMCKTVICCRVTPLQKAQVVELVKRYKKAVTLAIG 815

  Fly  1197 DGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYK 1261
            |||||||||:.|.:|||||||||||||:::||:..:||:|:||||.||.|.|.|:.:.:.|||||
Zfish   816 DGANDVSMIKAAHIGVGISGQEGMQAVLSSDFSFAQFRFLQRLLLVHGRWSYLRMCKFLRYFFYK 880

  Fly  1262 NAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNG 1326
            |..|.|:.|||..:||||.|.:.|:.::.||||::|:||.|.:.::|:.|..:..|:.|.||..|
Zfish   881 NFTFTFVHFWYAFFCGFSAQTVYDEGFITLYNLVYTALPVLGMSLFDQDVNANWSLEFPQLYVPG 945

  Fly  1327 RLGVAYRPHDFWLILLDALYQSLVIFFVALCAYAES---------DVGIWEFGTTITASCLFANL 1382
            :|...:....|.:..|.:.|.|||:|||   .||.:         |...::....||.:||...:
Zfish   946 QLSQYFSKRAFMMCALHSCYSSLVLFFV---PYATTYDTARADGRDGADYQSFALITQTCLTVTV 1007

  Fly  1383 -VHCAIEIRSWTVLHVLSIVLSLGSFYL--FAIVYDSVCMNCFGVRSSYWVIFV-----CFASAV 1439
             |...:::..|||::.|.:..|||.|:.  |.:..|.:    |.:|.:.:. |:     |.....
Zfish  1008 CVQLGLDLSYWTVVNHLFVWGSLGMFFFLTFTMYTDGL----FKLRPASFA-FIGTARNCLNQPN 1067

  Fly  1440 HWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKV---ILQSKRERSRGEALLVTWSRSTSASSIY 1501
            .||.:.|:.::.|||.:....:...:.|..:.||   :.|.|....|....|...|...|..:..
Zfish  1068 VWLTVALTALLCVLPVVAYRFIYCQIYPTINDKVRYKMRQMKEPAPRPRPRLTRRSTRRSGYAFS 1132

  Fly  1502 RITDYG 1507
            ....||
Zfish  1133 HAQGYG 1138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	23/49 (47%)
		ATPase-Plipid	250..1473	CDD:273734	399/1266 (32%)
		E1-E2_ATPase	302..>394	CDD:278548	37/91 (41%)
		Cation_ATPase	<880..965	CDD:289987	36/85 (42%)
		HAD_like	<1177..1240	CDD:304363	39/62 (63%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	85/261 (33%)
atp8b5a	XP_021332106.1	P-type_ATPase_APLT_Dnf-like	36..974	CDD:319770	370/1131 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.930