DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and atp8a2

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_017209427.1	Gene:	atp8a2 / 100330943	ZFINID:	ZDB-GENE-100209-2	Length:	1211	Species:	Danio rerio

Alignment Length:	1431	Identity:	421/1431 - (29%)
Similarity:	655/1431 - (45%)	Gaps:	342/1431 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 ILPPGHKEEPAR--EPSAPT---------------SATGGRGHSRQASRSESIYTLRRTEAPPWW 208
            :|.|..::.|.|  :|..|.               ||||.|....:.|.:.|       :|.|
Zfish    18 VLTPLSQDSPLRQDQPLGPNMCSRLADRFEKRPACSATGYRKAEDEMSGTTS-------QADP-- 73

  Fly   209 KRLTLCNYNTGDKFEERSYRTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQ 273
                          .:.:.|||:.|.....|          :..|.:.|.||.:|:|:|:.|.||
Zfish    74 --------------VDATARTVLLNRAQTTK----------YCDNHVSTAKYGILTFLPRFLYEQ 114

  Fly   274 FHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRV 338
            ..|.||.:|:||.|:..:|::|..|:...::|::|:|.|..:|::.||.:|..:|..:|.....|
Zfish   115 IRRAANAFFLFIALMQQIPDVSPTGRYTTLVPLIFILTVAGIKEIIEDYKRHKADNTVNKKKTTV 179

  Fly   339 YDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRRE-- 401
            .  ....::.:.|:::.|||||.::|.:.:|||::::.:|:||.:||.:|.:||||||||.|:
Zfish   180 L--RNGAWQTIIWKQVAVGDIVKVTNGQHLPADMVIVSSSEPQAMCYTETSNLDGETNLKIRQGL 242

  Fly   402 -VVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDY 465
             :...|:.::.:...|   .|:|.:.|...||.|.|.|........|:..:.:|||.::|:||.:
Zfish   243 SLTASFQSLEDLIALS---GRLECEGPNRHLYDFTGTLRLDNHNPAPLGPDQVLLRGAQLRNTQW 304

  Fly   466 IEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFP 530
            :.|||||.||::|.|.|::....|||.||:..|:.::....|||::.:|.:||..:|....|...
Zfish   305 VVGIVVYTGHDSKLMQNSTKAPLKRSNVERVTNMQILVLFGILLVMALVSSIGAAIWNKQHTDEA 369

  Fly   531 VPYLP-PNKLTANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQT 594
            ..||. ...::.|.  .:...|:|::...:||:||.||:|:.|..|...|:.:|:::.|||:...
Zfish   370 CWYLSRAGDISLNF--AYNLLTFIILYNNLIPISLLVTLEVVKFTQALFINWDVEMYYAETDTPA 432

  Fly   595 ECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPS-----ELEKIYSKPGA-- 652
            ..|..|:.|||||::::|:|||||||.|.|.|::|.:.|..|.|.|.     .:|.....|..
Zfish   433 MARTSNLNEELGQVKYLFSDKTGTLTCNVMHFKKCTIAGITYGHFPDLDCDRSMEDFSHLPSTSH 497

  Fly   653 -----PAPPLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGI 712
                 ..|.||.|...|.            |.:.:|.|||.::|:|:||:    |.|:
Zfish   498 NSTEFDDPALIQNIEKNH------------PTSPQICEFLTMMAVCHTVV----PERE------- 539

  Fly   713 IEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPS 777

Zfish   540 ----------------------------------------------------------------- 539

  Fly   778 PPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITS 842

Zfish   540 ----------------------------------------------------------------- 539

  Fly   843 IATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILV 907
                                        |.:.:|:|.||||.|||..|.|.......|:|:.:::
Zfish   540 ----------------------------DNQIIYQASSPDEGALVKGAKSLGFVFTARTPHSVII 576

  Fly   908 SMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGIL 972
            .  ..|..:.||:|.||.|.|:||.||::|| ..:..:.||.||||:.|...|...|.      .
Zfish   577 E--ARGKEQTYELLNVLEFSSNRKRMSVIVR-TPTGNLRLYCKGADNVIFERLNVTSQ------Y 632

  Fly   973 REQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTL 1037
            :|.|...|:::|.||||.|..|...|....|.:|...:..|...|::|.::|.:.:..:|.||.|
Zfish   633 KELTVAHLEQFATEGLRTLCFAYVDLEEGAYLEWLKEYNRISTVLKDRAQKLEECYELIEKNLLL 697

  Fly  1038 LGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDA 1102
            ||||.||||||.|||||||:|:.|.|.:|||||||.||||||.||.:|.:..|.||.:...|.||
Zfish   698 LGATAIEDRLQAGVPETIATLMRADIKIWVLTGDKQETAINIGYSCRLVSHGMSLIIVNEDSLDA 762

  Fly  1103 AETAINFYLTDMENDKTTSTLGYGQSLRKK-QRALVVDGKTLTFILDPKSKLILPFLRLSKRCAS 1166
            ....:..:.:.:           |.||||: :.||::||:||.:.|  ..::...||.|:..|.:
Zfish   763 TRATLTAHCSSL-----------GDSLRKENELALIIDGQTLKYAL--SFEVRQAFLDLALSCKA 814

  Fly  1167 VLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLP 1231
            |:|||.:||||:.:|.:||:.:...|||||||||||.|||.|.|||||||.|||||..::|:::.
Zfish   815 VICCRVSPLQKSEIVDMVKKHVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNSSDYSIA 879

  Fly  1232 RFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIF 1296
            :|.|||:|||.||.|.|:|:::.|||.||||.....:..|:....|||||::.::..:.|||:||
Zfish   880 QFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIF 944

  Fly  1297 TSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVALCAYAE 1361
            |:|||..:|::|:..::..:::.|.||:..:....:....||...::||..|:::|:..|.| .|
Zfish   945 TALPPFTLGIFDRPCSQQNMIRFPQLYRITQNAEGFNTKVFWGHCINALIHSIILFWFPLKA-LE 1008

  Fly  1362 SD-------------VGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIV 1413
            .|             ||...:...:...||.|.:     |..:||....|::..|:..:.||..|
Zfish  1009 HDTPFDNGNSVDYLFVGNIVYTYVVVTVCLKAGM-----ETTAWTRFSHLAVWGSMVLWMLFFAV 1068

  Fly  1414 YDSV----------------CMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTVR 1462
            |.::                .|.|:    |:|:..:...:|     .:|..||....|   .|||
Zfish  1069 YSAIWPTIPIAPDMLGQAGRVMQCW----SFWLGLILVPTA-----CLLKDVVWNAGR---RTVR 1121

  Fly  1463 ISLCPD---------DSTKVILQSKRERSRGEA--LLVTWSRSTSASSIYRITDYGSKNQIITTI 1516
            .:|..:         |....:|:....||..|.  ||....|.|.:|       .|..|.:..|:
Zfish  1122 KTLLEEVQELEARAVDPGAAVLRDASGRSLNERAHLLTRVFRKTPSS-------VGRSNSVQQTV 1179

  Fly  1517 T 1517
            :
Zfish  1180 S 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	19/49 (39%)
		ATPase-Plipid	250..1473	CDD:273734	389/1277 (30%)
		E1-E2_ATPase	302..>394	CDD:278548	29/91 (32%)
		Cation_ATPase	<880..965	CDD:289987	33/84 (39%)
		HAD_like	<1177..1240	CDD:304363	36/62 (58%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	77/273 (28%)
atp8a2	XP_017209427.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830