DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18636 and TMPRSS2

DIOPT Version :9

Sequence 1:	NP_995714.2	Gene:	CG18636 / 2768923	FlyBaseID:	FBgn0032551	Length:	349	Species:	Drosophila melanogaster
Sequence 2:	NP_001128571.1	Gene:	TMPRSS2 / 7113	HGNCID:	11876	Length:	529	Species:	Homo sapiens

Alignment Length:	315	Identity:	93/315 - (29%)
Similarity:	141/315 - (44%)	Gaps:	60/315 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TALIGVPTFVGIILMF-QLLHS-GCS-----QFLDPACGIRTQSRTAYRIINGHTAKYNSSPWMV 60
            |:.:.:.|..|.:.:: :|.|| .||     .....|||:...|....||:.|.:|...:.||.|
Human   244 TSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQV 308

  Fly    61 FLHSTTDMFVCGGSLITDKLVLTAAHCF---IANQ-HLVARLGEYERTRSEECTGYYCNFREEHM 121
            .|| ..::.|||||:||.:.::|||||.   :.|. |..|..|...::......||        .
Human   309 SLH-VQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGY--------Q 364

  Fly   122 VDAGFKHKLYDPNTHANDIAILRLSKSVVYRDNIRPICVVWDHRWRHYLDKIDLLTATGWGKTQM 186
            |:....|..||..|..||||:::|.|.:.:.|.::|:|:   ......|....|...:|||.|:.
Human   365 VEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCL---PNPGMMLQPEQLCWISGWGATEE 426

  Fly   187 ESDS----DALQTLDIRRQ-------------PPDVCAKFIGQTIAGNQFCAGNWDSNLCNGDSG 234
            :..:    :|.:.|.|..|             |..:||.|:          .||.||  |.||||
Human   427 KGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFL----------QGNVDS--CQGDSG 479

  Fly   235 GPLGAVITHKNTQRFVQVGIASYTNRNCQKA---SVFTDVLSHAEFILRVWRMYG 286
            |||   :|.||...:: :|..|: ...|.||   .|:.:|:...::|.|..|..|
Human   480 GPL---VTSKNNIWWL-IGDTSW-GSGCAKAYRPGVYGNVMVFTDWIYRQMRADG 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18636	NP_995714.2	Tryp_SPc	44..278	CDD:214473	77/257 (30%)
CG18636	NP_995714.2	Tryp_SPc	45..278	CDD:238113	76/256 (30%)
TMPRSS2	NP_001128571.1	DUF3824	<44..91	CDD:289625
		LDLa	150..185	CDD:238060
		SRCR_2	190..283	CDD:292133	10/38 (26%)
		Tryp_SPc	292..521	CDD:214473	77/257 (30%)
		Tryp_SPc	293..524	CDD:238113	77/259 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910