DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18636 and TMPRSS3

DIOPT Version :9

Sequence 1:	NP_995714.2	Gene:	CG18636 / 2768923	FlyBaseID:	FBgn0032551	Length:	349	Species:	Drosophila melanogaster
Sequence 2:	NP_076927.1	Gene:	TMPRSS3 / 64699	HGNCID:	11877	Length:	454	Species:	Homo sapiens

Alignment Length:	280	Identity:	74/280 - (26%)
Similarity:	109/280 - (38%)	Gaps:	74/280 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ACGIRTQSRTAY--RIINGHTAKYNSSPWMVFLHSTTDMFVCGGSLITDKLVLTAAHC------- 87
            |||    .|..|  ||:.|:.:..:..||...| ......:||||:||...::|||||
Human   206 ACG----HRRGYSSRIVGGNMSLLSQWPWQASL-QFQGYHLCGGSVITPLWIITAAHCVYDLYLP 265

  Fly    88 --FIANQHLVARLGEYERTRSEECTGYYCNFREEHMVDAGFKHKLYDPNTHANDIAILRLSKSVV 150
              :.....||:.|.               |....|:|:....|..|.|....||||:::|:..:.
Human   266 KSWTIQVGLVSLLD---------------NPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLT 315

  Fly   151 YRDNIRPIC------------VVWDHRWRHYLDKIDLLTATGWGKTQMESDSDALQTLDIRRQP- 202
            :.:.|:|:|            |.|               .:|||.|: :...||...|:....|
Human   316 FNEMIQPVCLPNSEENFPDGKVCW---------------TSGWGATE-DGAGDASPVLNHAAVPL 364

  Fly   203 --PDVC--AKFIGQTIAGNQFCAGNWDSNL--CNGDSGGPLGAVITHKNTQRFVQVGIASYTNRN 261
              ..:|  ....|..|:.:..|||.....:  |.|||||||  |...:...:.  ||..|: ...
Human   365 ISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPL--VCQERRLWKL--VGATSF-GIG 424

  Fly   262 C---QKASVFTDVLSHAEFI 278
            |   .|..|:|.|.|..::|
Human   425 CAEVNKPGVYTRVTSFLDWI 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18636	NP_995714.2	Tryp_SPc	44..278	CDD:214473	68/264 (26%)
CG18636	NP_995714.2	Tryp_SPc	45..278	CDD:238113	67/263 (25%)
TMPRSS3	NP_076927.1	LDLa	74..107	CDD:238060
		SRCR_2	112..210	CDD:292133	3/7 (43%)
		Tryp_SPc	216..444	CDD:214473	68/264 (26%)
		Tryp_SPc	217..447	CDD:238113	68/265 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910