DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18636 and TMPRSS11B

DIOPT Version :9

Sequence 1:	NP_995714.2	Gene:	CG18636 / 2768923	FlyBaseID:	FBgn0032551	Length:	349	Species:	Drosophila melanogaster
Sequence 2:	NP_872308.2	Gene:	TMPRSS11B / 132724	HGNCID:	25398	Length:	416	Species:	Homo sapiens

Alignment Length:	288	Identity:	72/288 - (25%)
Similarity:	124/288 - (43%)	Gaps:	54/288 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ILMFQLLHSGCSQFLDPACG--IRTQSRTAYRIINGHTAKYNSSPWMVFLHSTTDMFVCGGSLIT 77
            |.:.::..:......:..||  :.....|..:|:||.::...:.||...: .......||.|||:
Human   153 IKLMEISKAASEMLTNNCCGRQVANSIITGNKIVNGKSSLEGAWPWQASM-QWKGRHYCGASLIS 216

  Fly    78 DKLVLTAAHCFIANQHLVARLGEYERTRSEECT---GYYCN--FREEHMVDAGFKHKLYDPNTHA 137
            .:.:|:|||||.            ::..|::.|   |...|  :....:.:..|......|..|
Human   217 SRWLLSAAHCFA------------KKNNSKDWTVNFGIVVNKPYMTRKVQNIIFHENYSSPGLH- 268

  Fly   138 NDIAILRLSKSVVYRDNIRPICVVWDHRWRHYLDKIDLLTATGWGKTQMES------DSDALQTL 196
            :|||:::|::.|.:.:.||.||:   ...:..|.:.|.:..||||...|..      ..|.|:.:
Human   269 DDIALVQLAEEVSFTEYIRKICL---PEAKMKLSENDNVVVTGWGTLYMNGSFPVILQEDFLKII 330

  Fly   197 DIRRQPPDVC------AKFIGQTIAGNQFCAG--NWDSNLCNGDSGGPLGAVITHKNTQRFVQVG 253
            |.:     :|      :.|:..|:    .|||  :.:::.|..|||||| |....:|....  ||
Human   331 DNK-----ICNASYAYSGFVTDTM----LCAGFMSGEADACQNDSGGPL-AYPDSRNIWHL--VG 383

  Fly   254 IASYTNRNC---QKASVFTDVLSHAEFI 278
            |.|:.: .|   .|..|:|.|.|:..:|
Human   384 IVSWGD-GCGKKNKPGVYTRVTSYRNWI 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18636	NP_995714.2	Tryp_SPc	44..278	CDD:214473	67/255 (26%)
CG18636	NP_995714.2	Tryp_SPc	45..278	CDD:238113	67/254 (26%)
TMPRSS11B	NP_872308.2	SEA	45..143	CDD:279699
		Tryp_SPc	184..410	CDD:214473	67/255 (26%)
		Tryp_SPc	185..413	CDD:238113	68/256 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910