Protein Alignment Remo and adgrb3

DIOPT Version :10

• Sequence 1: NP_572870.2
• Gene: Remo / 2768909
• FlyBaseID: FBgn0030466
• Length: 1797
• Species: Drosophila melanogaster
• Sequence 2: XP_068069198.1
• Gene: adgrb3 / 566117
• ZFINID: ZDB-GENE-070424-99
• Length: 1560
• Species: Danio rerio
• Alignment Length: 1667
• Identity: 308/1667 - (18%)
• Similarity: 522/1667 - (31%)
• Gaps: 554/1667 - (33%)

  Fly    50 SCRSTAEN-----------IHSLKIRCDEQQITNWRELDFG-EDVTSIVSINAS----------- 91
            :|..|.||           ::..:|.|.|..:..::...|. |.:..::.||.|
Zfish    54 NCTWTLENPDPTKYSIYLKLYKREISCSEFSLLAYQFDHFSHEKINELLRINESIVHLCDDAKNI 118

  Fly    92 -------KNSIAL--ITAEDFRNFTELKRLD-----LSFNLLTELDKDTFG--------DSLAHL 134
                   ||.:.|  :...|:...|..|..|     :.|.:|.:.....||        ::....
Zfish   119 NVFLHYDKNFVQLRRVFPYDYNGLTTKKTEDEERSVVEFVVLNKASPSQFGCQVLCTWLENCLKA 183

  Fly   135 EKLKLAG------NAISHIYEGTFDQMPKLKLLDLSGNPLACDC--------------------- 172
            ||.:..|      ....|:.:|..:.:..|..:.|..||....|
Zfish   184 EKAESCGIVYAKCTCPQHLGDGESESVLMLSNVVLPLNPQTEGCLTPQVRTAQVCNLSAEVRRPS 248

  Fly   173 ----GLI---------------------------------------WLIAWSS-------SREVR 187
                |:|                                       | ..|||       ..:||
Zfish   249 KEEYGMIGEHTVKSQRPRSVHDTKGLQERDESAKFMAQTGDPGAEEW-SQWSSCSVTCGQGSQVR 312

  Fly   188 LQPPPKCESP-GNFRGMPLKKLRV--------------------------GKDFHCET-LLQPLL 224
            .:   .|.|| |:....||::.||                          |:.....| :..|
Zfish   313 TR---TCVSPYGSHCSGPLRESRVCNNTAPCPVHGSWEEWSPWSLCSFTCGRGHRTRTRICTP-- 372

  Fly   225 ELIPSQNQVAFEGDELQLK-CHAPRVAIGVPRESEDLPTKAYVFWG-WSE-KIRAKNSTEDIIYQ 286
               |.....|.:|.|.|.| |:   :|: .|.:.:      :..|. ||: .:...|.|:....|
Zfish   373 ---PQHGGRACDGPETQSKLCN---IAL-CPVDGQ------WQEWSPWSDCSVTCANGTQQRKRQ 424

  Fly   287 DPTKVFGDVNLETR-HSTDSGILQSILRIASLTQNHTGMWDCTLRSQQANLSQAI-VLHVVAKGT 349
            ......|  ..|.| |..:|....:....|:...|....|....:|......:.: |...:|...
Zfish   425 CSAAAHG--GSECRGHWAESRECSNPECTANGQWNPWAAWSGCSKSCDGGWQRRVRVCQGLAVTG 487

  Fly   350 LYCEARVVHTNK-------GTYH-----------WPRTMRGETVLQECVEEPSDA--TQARRASH 394
            ..||.......:       ..|.           |.||..||.....|   |.:|  |.:||.|.
Zfish   488 QPCEGSGEEVRRCSEQRCPAPYEICPEDYAVSMLWRRTPSGELAFNRC---PPNATGTTSRRCSL 549

  Fly   395 ECGPSGEWLNLDTESCV------------------------------------YVSETT------ 417
            :......|.......|:                                    :|.:||
Zfish   550 DHRGVAYWEQPSYARCIANEYRYLQQSCASISASAASDKQHSDRHEGSRSHVTFVRKTTVQGHLA 614

  Fly   418 ---RIL-----EQFAKVNLTLTKGQN--------ALEIARRLHNFTQAQTQLNRIRDPMDLEYIA 466
               |.|     .|..||.|.||:.:|        ::||   |.|.|....:.:......|::...
Zfish   615 KGQRNLAGDGMSQVTKVLLDLTQRRNFYAGDLLSSVEI---LRNVTDTFKRASYEPSSDDVQNFF 676

  Fly   467 RTLVKYLDQ-----LEQPQQQQEISHLLMDIVSQLLNLPAHLFRAAQSEQGTGQRLLHVVESSAM 526
            :.:...|::     .|..||....|..||.:..:.:::           .|.|.:..|   |:.:
Zfish   677 QIISNLLEEENREKWEDAQQIYPGSVELMQVTEEFIHI-----------VGLGMKDFH---SAYL 727

  Fly   527 RLALASTQAEPLPAEMI------PWRGSLAQQRNLFVEFFNISLDAFVSLSCVWLEQSPRGFQCN 585
            ......|..:.|||..:      |.:|     |...|::...|.|..|         .|:|.
Zfish   728 MTGNLVTSIQRLPAVSVMTDINFPMKG-----RKGMVDWARNSEDKVV---------IPKGL--- 775

  Fly   586 SANDTIPMYEHGDIDAAIQLPYSVIGNSSTTLPATTTIRSLRLMISLHRNGKLLPNLRGSHNESL 650
                .:|  :..|:|.:   |..::|        ....::|.||:...||           |.::
Zfish   776 ----FVP--QAADMDGS---PVFILG--------MVLYKTLGLMLPAPRN-----------NTAV 812

  Fly   651 SSAIIGILAYSSDGEALQFRADNELDPEEDVYQQRVTVMLRAHPYHNPLSAPQPAWWDADEQR-- 713
            :|.:|.:                .:.||..|.:.::.:.| ||..:..:: |..|.||:....
Zfish   813 NSKVIAV----------------TVRPEPKVTEAQLEIEL-AHLANGTMN-PFCALWDSSVMNDS 859

  Fly   714 ---WETSVCQQHYQHRTLVMFSCSRTGYYGLLQRSQYLNDFRSEESGARFRHPPAAVYAGCGLLF 775
               |.:..|:......:.....|.|...:.:|  :|...:...|.||.    |...:..||||
Zfish   860 WGSWSSKGCRTVLTDASHTKCLCDRVSTFAIL--AQQPREIAMEYSGV----PSVTLIVGCGL-- 916

  Fly   776 ACCAF--NAVTFAVFGRAVRINRVQRHALVNTWLALGALALAFSLGIYQTASQPQCRLLGLLMHY 838
            :|.|.  .||.:||..|.:|..|  ...|:|..|::....:...:|..||.:...|.:....:|:
Zfish   917 SCLALITLAVVYAVLWRYIRSER--SIILINFCLSIICSNILILVGQTQTHNAGICTMTTAFLHF 979

  Fly   839 LGLCVLLWVCVSLSSMYKRLT-KTTTSGQGQCPGQDMEPQRERERKPILGIYLVGWGIALLICGI 902
            ..|....||.......|..:| |..|               ...||..|   .:|||:..|:..|
Zfish   980 FFLASFCWVLTEAWQSYMAVTGKVRT---------------RLIRKRFL---CLGWGLPALVVAI 1026

  Fly   903 SSAVNLAE-YATYDYCFLH-SSTTLNALLVPAVILVIFCGILALCIYYQLSQQAVNVLQLQMQHQ 965
            |.....|: |.|..||:|. ....|.|.:.||..:|:...::.:.::.:|..:. .:|..:::|:
Zfish  1027 SMGFTKAKGYGTPQYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSRD-GILDKKLKHR 1090

  Fly   966 QNRQYSDNNTQATEHIDLDWLDANGSATTAAIGGGSGNHGGRKEQDHMQEQYSTLSNPLSSIVDD 1030
            .. |.|:.:|..|    |........:|||.                   ..:|.||.::|
Zfish  1091 AG-QMSEPHTGLT----LKCAKCGVVSTTAL-------------------SATTASNAMAS---- 1127

  Fly  1031 FERSNLSHLRGHFIFLVLYAGAWLSAA-AYVNGGQELYVLSFAGCCSVLGIFLLIFYNLSRNDAR 1094
                    |....:.|.|.|..|:||. |..:....|:.:.||...|:.|..:::.:.:.|.:.:
Zfish  1128 --------LWSSCVVLPLLALTWMSAVLAMTDKRSILFQILFAVFDSLQGFVIVMVHCILRREVQ 1184

  Fly  1095 QAW----------------------------------------SQGRDGRSIPAKLVT------- 1112
            .|:                                        :..:|..|..|..:|
Zfish  1185 DAFRCRLRNCQDPINSDATGTFPNGHAQIMTDFEKDVDIACRSALHKDMGSCRAATITGALSRIS 1249

  Fly  1113 YNNGSQARGAHPSSMMPGPGTAMISNSIVAYKA----NPGPGSLYEANNSAGSRSNSQCSRSMRS 1173
            .|:..:.:|....:....||..| |..|:...:    :.|.|.|.|           ||..|...
Zfish  1250 LNDEEEEKGPEGLNYSTLPGNIM-SKVIIQQPSGLHMSMGVGDLGE-----------QCLDSTAD 1302

  Fly  1174 QTRS------QTRSQQEQLLQANGAGGVTIINNTSGQPGAGG--------GPAAGGVSGSTGGAP 1224
            ..|:      .|..|.||.|.|         ::.||.|..|.        ..::|.|....|.:.
Zfish  1303 MRRTVYLCTDDTTRQSEQELSA---------HDLSGHPQPGQMETDYIVLPRSSGAVVSGAGSSS 1358

  Fly  1225 VP----PHSLNALLHGSSHDLI----PSAEIFYNPNQINVARKFFKKQKRLAKRNNFELQRQTMP 1281
            ||    ..|..:::...|||.:    ..||....|:.:          :.:...:.:.:|.:.|.
Zfish  1359 VPTLLKEESKMSMMDSLSHDRLMHYKMGAEFNLGPSGM----------EHMGMEHQYPVQAEHMQ 1413

  Fly  1282 QMQLQMQMQM--------------QLHSQHSLSDASSEQLYSRHHNAMTMLAGGSKINNTNLHYK 1332
            .:..:.:..:              :..:..::|.:|.|:..||:.:     ....|:.:|...:.
Zfish  1414 NLPFEPRTAVKNFLAEMEESGGLSRSETGSTISMSSLERRKSRYQD-----LDFEKVMHTRKRHM 1473

  Fly  1333 ------NQGSPMAGAPKEHGNMGAMSSG-GDSMQFKRFVPAS 1367
                  ||........::..|||.|... .:...::.|.|||
Zfish  1474 ELFQELNQKFQTLDRFRDIPNMGIMDKAMPNKNPWESFNPAS 1515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Remo	NP_572870.2	PPP1R42	<56..148	CDD:455733	25/142 (18%)
		LRR_8	107..168	CDD:404697	15/79 (19%)
		leucine-rich repeat	109..133	CDD:275378	6/36 (17%)
		leucine-rich repeat	134..157	CDD:275378	5/28 (18%)
		PCC	139..>205	CDD:188093	20/143 (14%)
		HRM	<366..412	CDD:413313	14/83 (17%)
		7tm_GPCRs	760..1101	CDD:475119	79/386 (20%)
		TM helix 1	763..787	CDD:320387	9/25 (36%)
		TM helix 2	799..820	CDD:320387	3/20 (15%)
		TM helix 3	830..852	CDD:320387	4/21 (19%)
		TM helix 4	887..903	CDD:320387	4/15 (27%)
		TM helix 5	921..944	CDD:320387	5/22 (23%)
		TM helix 6	1039..1061	CDD:320387	8/22 (36%)
		TM helix 7	1065..1090	CDD:320387	5/24 (21%)
adgrb3	XP_068069198.1	AGRB_N	30..201	CDD:465991	26/146 (18%)
		TSP1	294..341	CDD:214559	14/50 (28%)
		TSP1	346..396	CDD:214559	11/58 (19%)
		TSP1	401..450	CDD:214559	11/50 (22%)
		TSP1	456..506	CDD:214559	7/49 (14%)
		HormR	508..574	CDD:214468	15/68 (22%)
		GAIN	624..823	CDD:465137	50/276 (18%)
		GPS	846..891	CDD:460350	8/44 (18%)
		7tmB2_BAI3	901..1193	CDD:320655	82/354 (23%)
		TM helix 1	905..930	CDD:320655	9/30 (30%)
		TM helix 2	940..962	CDD:320655	4/21 (19%)
		TM helix 3	971..999	CDD:320655	5/27 (19%)
		TM helix 4	1009..1029	CDD:320655	9/22 (41%)
		TM helix 5	1047..1076	CDD:320655	5/28 (18%)
		TM helix 6	1123..1150	CDD:320655	10/38 (26%)
		TM helix 7	1155..1180	CDD:320655	5/24 (21%)