DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3857 and Smg9

DIOPT Version :9

Sequence 1:	NP_996330.1	Gene:	CG3857 / 2768908	FlyBaseID:	FBgn0023520	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_001014265.1	Gene:	Smg9 / 365215	RGDID:	1309888	Length:	520	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	119/509 - (23%)
Similarity:	200/509 - (39%)	Gaps:	154/509 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 RDREQ-ETWDRER---DKD-------------RKLERDREAEPSPSCYPDTPPA---LKTMIVNR 90
            |:|:. ..|:|||   .:|             .|...:|..:|.||..|..|||   |:..||
  Rat    37 RERDYIAPWERERRDGSEDPSTNVMQKTPIILSKPPAERSKQPPPSTAPAAPPAPAPLEKPIV-- 99

  Fly    91 TGEVRPADRCQMPLA--GGALVQGSGQLSAVPSSSVCAALVSSVPTSRDKGSCSG---------- 143
              .::|.:..:.|:|  |.:..:|    :|.|..:..|.         .||...|
  Rat   100 --LMKPREEGKGPVAATGASTPEG----TAPPPPTAPAP---------PKGEKEGQRPTQPVYQI 149

  Fly   144 ---GAGTAGTSAGAPNALQ-ELQPPRMNRPTPLIVANGIFNANARKLFHKTNTDFTVIGVLGGQS 204
               |.|||..:|..|...| :|.||...:.:..:|.:.:...::...:....||..|:||||.|.
  Rat   150 QNRGMGTAAPTAMDPVVGQAKLLPPERMKHSIKLVDDQMNWCDSAIEYLLDQTDVLVVGVLGLQG 214

  Fly   205 SGKSTLLNLLAAERSLDYDYYQHLFSPEADECIFATR---HKLKPNNGQKSILRPRTETLQFFIT 266
            :|||.:::||:|.            :||.|:..:..|   .::|...|.      :|..:.||||
  Rat   215 TGKSMVMSLLSAN------------TPEEDQRAYVFRAQSAEMKERGGN------QTSGIDFFIT 261

  Fly   267 RERHILLDTPPLMP-------VGKD----------SDHQDLYSLGTMAQLLSVCHILILVIDGLA 314
            :||.:.|||.|::.       :..|          ..:.::.||...|.|.:|||::|:|.|...
  Rat   262 QERIVFLDTQPILSPSILDHLINNDRKLPPEYNLPHTYVEMQSLQIAAFLFTVCHVVIVVQDWFT 326

  Fly   315 -LEQLRLINAALRLRPTLHCKGYV----------RDHMPQVVFVRARAHRIDF---EIQQRE-RL 364
             |...|.:..|..::|:.....:.          .::.|.:||::.:|.|.||   :::|.. .:
  Rat   327 DLSLYRFLQTAEMVKPSTPSPSHESSSAAGSDEGTEYYPHLVFLQNKARREDFCPRKLRQMHLMI 391

  Fly   365 DKKLAYLYGPTGLPIYRGRG------------------DARCLNTFLLPEVSS------------ 399
            |:.:|:.:       .|.:|                  ||. :|.||:|.:.|
  Rat   392 DQLMAHSH-------LRYKGTLSMLQCNIFPGLPPDFLDAE-VNLFLVPFMDSEAENENPPRAGP 448

  Fly   400 NKATAF--------HSCLGELVRQFRERILGCTRISMCHTSTELSEAIWFEILA 445
            ..:..|        |.....||.:.|.:::...|..:.||.  |:|..||...|
  Rat   449 GSSPLFSLLPGYRGHPSFQSLVSKLRSQVMSMARPQLSHTI--LTEKNWFHYAA 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3857	NP_996330.1	P-loop_NTPase	188..>318	CDD:304359	43/150 (29%)
Smg9	NP_001014265.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..94		16/56 (29%)
Smg9	NP_001014265.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	107..143		10/48 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352916
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	73	1.000	Inparanoid score	I5195
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1436399at2759
OrthoFinder	1	1.000	-	-		FOG0008337
OrthoInspector	1	1.000	-	-		oto97378
orthoMCL	1	0.900	-	-		OOG6_105416
Panther	1	1.100	-	-	LDO	PTHR14270
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.760