DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42271 and INPP4B

DIOPT Version :9

Sequence 1:	NP_996434.2	Gene:	CG42271 / 2768892	FlyBaseID:	FBgn0259166	Length:	1280	Species:	Drosophila melanogaster
Sequence 2:	XP_011530693.1	Gene:	INPP4B / 8821	HGNCID:	6075	Length:	947	Species:	Homo sapiens

Alignment Length:	1098	Identity:	271/1098 - (24%)
Similarity:	433/1098 - (39%)	Gaps:	299/1098 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 PICETALSCDTLPLDTLGRPPNPQVVCSLLPTAGEDCVWREHARTELQERTRTPQFLCTMRFQRS 265
            |..|..|:|..|......|..|..|..|::....:...  .::.||:.|.||.|.||..:.|...
Human    39 PQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLT--RYSSTEIVEGTRDPLFLTGVTFPSE 101

  Fly   266 AGLSASTRLRFSVFDVRER----MTLTAVP-------------LGHAEVALGVIQDTSRLRLPL- 312
            ..:...|:::.:|:||:::    :..:.:|             ||:|...:|.:..:....|.|
Human   102 YPIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKEQLLVLS 166

  Fly   313 --TSPRGE-CGFITLASWSPDAAVEPGQSGNGPPRSSTQLFDGSAGAGGATTSSRRAHRRTQSLP 374
              ||..|: .|.|.:      :.|:.|:..:|.....|....|...|.....::..:.....:||
Human   167 LRTSDGGKVVGTIEV------SVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLP 225

  Fly   375 PKLGVRLFVPQQCGLQRVCSNPRLRTYRLHSSLGADISVQETLLESRLCCQLPQQLLSIWIQREK 439
                         .|..|..||..:.||..:|....:.::|.:.||.|...:|::|:|:.|:.:.
Human   226 -------------FLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDL 277

  Fly   440 ELLQEISGMGELSGEWRWRQMNLLEEHLRLLKDYSQAKQNIQQLARD-GVSFKRSSAKADESLEF 503
            ...|||..:||||..|...:.|:|....:::..|...   :.:|::: |.|||.||:|.:::|||
Human   278 CRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDI---LTELSKETGSSFKSSSSKGEKTLEF 339

  Fly   504 LPVNLHVQRMWAQNDTL--------QRRGLLDVVTVGAFTRHDPKGRKCGGLIKLLQESKSWK-- 558
            :|:|||:|||...:..|        |...|.||:||||...|. :|.|.|||.|||...::.:
Human   340 VPINLHLQRMQVHSPHLKDISSGIPQIDALYDVITVGAPAAHF-QGFKNGGLRKLLHRFETERRN 403

  Fly   559 -------LEQSNACKVQAANDAVQATKQLRKEIVELMSQLLQLASRRSSMDMMPLCNQMVARTRT 616
                   ....|..|   |.:.:....||:..|......||..||:.|...:......:..:|..
Human   404 TGYQFIYYSPENTAK---AKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTEL 465

  Fly   617 LLNLWEPSIVEEAVAFIERHRIIEEPENVLMEPMSPFRKITQQLTALELKSPELEDFATPVVAPP 681
            .::.::..:|..|:..:...|    |..:|.:|.|| :..|::.:
Human   466 FVHAFKDQLVRSALLALYTAR----PGGILKKPPSP-KSSTEESS-------------------- 505

  Fly   682 DLWPRGQPPLMRSNSWHPSNSSPSSSLDIRAIDSLQHVVKCYNDHLRSLEQGRQPGRQADDEEQE 746
               |:.|||:||..                  ||:.|    ::|:               |||:
Human   506 ---PQDQPPVMRGQ------------------DSIPH----HSDY---------------DEEE- 529

  Fly   747 EATYQSLPVAWQTQSEVSAGTQIPPSDNPADLSVLQLIDLDEIGRQAQRQRHHQPPAGFLDTKLM 811
                      |
Human   530 ----------W------------------------------------------------------ 530

  Fly   812 SSSPSANYYRPTEEPEPLDLTQLNIEASVMC---LVSKLKFFCGRCDSPAIRLRHPKAPIKREGF 873
                              |....|:..|:.|   :|.||                    |:|:|
Human   531 ------------------DRVWANVGKSLNCIIAMVDKL--------------------IERDG- 556

  Fly   874 AVAPQQAPDVIAASAASGKQAPNLALDLKPQSVDSDGITTTGSVAVKKGNKFTDGLDLSMTTDWA 938
                        .|..||.              ::||         :|....||.:......||.
Human   557 ------------GSEGSGG--------------NNDG---------EKEPSLTDAIPSHPREDWY 586

  Fly   939 AELRPSMRKLRHAMDRLLKTARLMHSVQRLQQDMRCNRLQASIM--YRRDVCFSQALTALVSSLM 1001
            .:|.|.:..|:..|..::..|:...:...||:  ....|...:|  .|||:.|||||..||...:
Human   587 EQLYPLILTLKDCMGEVVNRAKQSLTFVLLQE--LAYSLPQCLMLTLRRDIVFSQALAGLVCGFI 649

  Fly  1002 LRLWGSELDMGYLVMLRDLGPLAYFEGLLTLYGNEADMWSDMCIAIEDLSAVSFQLVRAQGEVAQ 1066
            ::|..|..|.|:|..|..:|.:..:||||:.|.:|..|..||.:.|.||..|:|:::.|:   :.
Human   650 IKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAK---SN 711

  Fly  1067 TPTPRITGSRQ--ALEVQLPVPE-HSLPGNGNSISFK------ITPVFFNIGINEKASFAETLGQ 1122
            ...|.|||.|:  .:||:||... .|||     :..|      :.||.||:||||:.:.||..|.
Human   712 DVLPVITGRREHYVVEVKLPARMFESLP-----LQIKEGQLLHVYPVLFNVGINEQQTLAERFGD 771

  Fly  1123 TKEQHRSNWDNYLRLSQYFGRY-RKLG---LGSVDTGESLQSLLGFMEQQLRANVSKNVKILHLA 1183
            ...|...|.:|:..|.:|:..: .|:.   :........|::||..:.|.:::...|||:|:.||
Human   772 VSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRKNVEIMWLA 836

  Fly  1184 EDACRLMDGLRFTSCKSAKDRTGMAVTLEQCRVLVREFQLPAKHVPYALSTMRSEGTR 1241
            ...||.::|:|||.||||||||.|:||||||.:|..|.||.......||..|||..|:
Human   837 ATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRSRQTQ 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42271	NP_996434.2	PH_INPP4A_INPP4B	1..145	CDD:270091
		PH	21..123	CDD:278594
		C2	201..318	CDD:301316	31/136 (23%)
INPP4B	XP_011530693.1	C2A_Copine	39..175	CDD:176013	32/137 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151741
Domainoid	1	1.000	379	1.000	Domainoid score	I853
eggNOG	1	0.900	-	-		E1_KOG4428
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	379	1.000	Inparanoid score	I2073
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46978
OrthoDB	1	1.010	-	-		D129165at2759
OrthoFinder	1	1.000	-	-		FOG0002887
OrthoInspector	1	1.000	-	-		otm40269
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12187
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5733
SonicParanoid	1	1.000	-	-		X1907
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.900