DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42271 and Inpp4a

DIOPT Version :9

Sequence 1:	NP_996434.2	Gene:	CG42271 / 2768892	FlyBaseID:	FBgn0259166	Length:	1280	Species:	Drosophila melanogaster
Sequence 2:	XP_038940152.1	Gene:	Inpp4a / 80849	RGDID:	68386	Length:	994	Species:	Rattus norvegicus

Alignment Length:	1128	Identity:	301/1128 - (26%)
Similarity:	472/1128 - (41%)	Gaps:	229/1128 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 QEQLQLHGQPAEELSVPVPTEVVAPFEELDLS------ELPICETALSCDTLPLDTLGRPPNPQV 225
            :|....||..|..:......:|.|....|.|:      :.||.|.:|:|..|...:|.|.||..|
  Rat     4 REHSPRHGARARAMQRASTIDVTADMVGLSLAGNIQDPDEPILEFSLACSELHTPSLDRKPNSFV 68

  Fly   226 VCSLLPTAGEDCVWREHARTELQERTRTPQFLCTMRFQRSAGLSASTRLRFSVFDVRERMTLTAV 290
            ..|:  |......|.:||:||:.|.|..|.||.::.|.:.:.::..|:::.||:||::|...|..
  Rat    69 AVSV--TTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQIKLSVYDVKDRSQGTMY 131

  Fly   291 PLGHAE-VALGVIQDT-SRLRLPLTSPRGE-CGFITLASWSPDAAVEPGQSGNGPPRSSTQLFDG 352
            .||... |...::||. .||.|.|.|...: .|.||:..|..:.     :|...||  .|:..|
  Rat   132 LLGSGTFVVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEE-----KSDQQPP--VTRSLD- 188

  Fly   353 SAGAGGATTSSRRAHRRTQSLPPKLGVR---LFVPQQCGLQRVCSNPRLRTYRLHSSLGADISVQ 414
                   |.:.|......:||...||:|   ..:.:...|:.|......|.||..::.|..:.:.
  Rat   189 -------TVNGRMVLPVDESLTEALGIRSKYASLRKDSLLKAVFGGAICRMYRFPTTDGNHLRIL 246

  Fly   415 ETLLESRLCCQLPQQLLSIWIQREKELLQEISGMGELSGEWRWRQMNLLEEHLRLLKDYSQAKQN 479
            |.:.||.|...:|:|.:.:.::.:...:.|:..:||||..|...:..::.::..::..|.:...:
  Rat   247 EQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTD 311

  Fly   480 IQQLARDGVSFKRSSAKADESLEFLPVNLHVQRMWAQNDTLQRRGLLDVVTVGAFTRHDPKGRKC 544
            :.|.  .|.|||.||.|||:.|||:|.|||:|||..|:|....:. .||||:||...| .:|.|.
  Rat   312 LHQY--KGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQN-YDVVTIGAPAAH-CQGFKS 372

  Fly   545 GGLIKLL---QESKSWKLEQ---SNACK--VQAANDAVQATKQLRKEIVELMSQLLQLASRRSSM 601
            |||.|.|   :|:|....|:   |:.|:  :....|.|:| |::..:|..|.:|:...|.|.|
  Rat   373 GGLRKKLHKFEEAKKHSFEECCTSSTCQSIIYIPQDVVRA-KEIIAQINTLKTQVSYYAERLS-- 434

  Fly   602 DMMPLCNQMVARTRTLLNLWEPSIVEEAVAFIERHRIIEEPENVLMEPMSPFRKITQQLTALELK 666
                    ..|:.|:...|      |..:|.:.                   .|..|.:|..:.|
  Rat   435 --------RAAKDRSATGL------ERTLAILA-------------------DKTRQLVTVCDCK 466

  Fly   667 SPELEDFATPVVAPPDLWPRGQPPLMRSNSWH----------PSNSSPSSSLDIRAIDSLQHVVK 721
                                     :.:||.|          .|.:||:|:      :..|.:::
  Rat   467 -------------------------LLANSIHGLNAARPDYIASKASPTST------EEEQVMLR 500

  Fly   722 CYNDHLRSLEQGRQPGRQADDEEQEEATYQSLPVAWQTQSEVSAGTQIPPSDNPADLSVLQLIDL 786
            ...|.|.:...||             ::..||.|.|..:........:..|        |:.| :
  Rat   501 NDQDTLMARWAGR-------------SSRSSLQVDWHEEEWEKVWLNVDKS--------LECI-I 543

  Fly   787 DEIGRQAQRQRHHQ-------PPAGFLDTKLMSSSPSANYYRPTEEPEPLDLTQLNIEASVMCLV 844
            ..:.:..|::|.|.       |.:....:|..:....|.:.|| |:|
  Rat   544 QRVDKLLQKERLHGEGGEDVFPCSSTCSSKKGNRDSQAYWIRP-EDP------------------ 589

  Fly   845 SKLKFFCGRCDSPAIRLRHPKAPIKREGFAVAPQQAPDVIAASAASGKQAPNLALDLKPQSVDSD 909
                    .||:|:               :..|...|.......::...:|       |....|.
  Rat   590 --------FCDAPS---------------STCPSSMPTAACHPHSNTHCSP-------PPEESSP 624

  Fly   910 GITTTGSVAVKKGNKFTDGLDLSMTTDWAAELRPSMRKLRHAMDRLLKTARLMHSVQRLQQDMRC 974
            |                         :|:..|.|.:..|...:..:...|:.......:|.....
  Rat   625 G-------------------------EWSEALYPLLTTLTDCVAMMSDKAKAAMVFLLMQDSAPT 664

  Fly   975 NRLQASIMYRRDVCFSQALTALVSSLMLRLWGSELDMGYLVMLRDLGPLAYFEGLLTLYGNEADM 1039
            .....|:.|||||.|.|.||||:...:::|.....|.|:|..|..:|.||.||.||:.||.|..|
  Rat   665 IASYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDGGFLRQLYTIGLLAQFESLLSTYGEELAM 729

  Fly  1040 WSDMCIAIEDLSAVSFQLVRAQGEVAQTPTPRITGSRQALEVQLPVPE---HSLPGNGNS-ISFK 1100
            ..||.:.|.||..|:|::.:|....:....|.|||:|....|::|:|.   .|||....| :..:
  Rat   730 LEDMSLGIMDLRNVTFKVTQATSNASSDMLPVITGNRDGFNVRIPLPGPLFDSLPREIQSGMLLR 794

  Fly  1101 ITPVFFNIGINEKASFAETLGQTKEQHRSNWDNYLRLSQYFGRYRKL----GLGSVDTGESLQSL 1161
            :.||.||:||||:.:.||..|.|..|...|.::.:||:.||.:::::    .|....:...|..|
  Rat   795 VQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPEL 859

  Fly  1162 LGFMEQQLRANVSKNVKILHLAEDACRLMDGLRFTSCKSAKDRTGMAVTLEQCRVLVREFQLPAK 1226
            |.|:.|.:.|..:|||.||..|.:.||.::|:||||||||||||.|:||||||.:|..|..:..:
  Rat   860 LRFLGQNVHARKNKNVDILWQAAEVCRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQ 924

  Fly  1227 HVPYALSTMRSEGTRMDNVLKNI 1249
            ....||..|||.|||.....||:
  Rat   925 VFTQALECMRSIGTREVVTQKNL 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42271	NP_996434.2	PH_INPP4A_INPP4B	1..145	CDD:270091
		PH	21..123	CDD:278594
		C2	201..318	CDD:301316	41/118 (35%)
Inpp4a	XP_038940152.1	C2A_Copine	44..157	CDD:176013	40/114 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	384	1.000	Domainoid score	I786
eggNOG	1	0.900	-	-		E1_KOG4428
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2871
Inparanoid	1	1.050	384	1.000	Inparanoid score	I1964
OMA	1	1.010	-	-		QHG46978
OrthoDB	1	1.010	-	-		D129165at2759
OrthoFinder	1	1.000	-	-		FOG0002887
OrthoInspector	1	1.000	-	-		otm44395
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12187
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1907
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980