Protein Alignment CG42271 and PREX2

DIOPT Version :9

• Sequence 1: NP_996434.2
• Gene: CG42271 / 2768892
• FlyBaseID: FBgn0259166
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: NP_079146.2
• Gene: PREX2 / 80243
• HGNCID: 22950
• Length: 1606
• Species: Homo sapiens
• Alignment Length: 1435
• Identity: 272/1435 - (18%)
• Similarity: 476/1435 - (33%)
• Gaps: 461/1435 - (32%)

  Fly    18 RFDKEGLLIITDRQEGFLWRSSEVR------VERWCKLRGNLLFYLKDKD-----PKSAVAG--- 68
            :|..|.:|......:|..:..:|::      |..:|:|.......::|||     .||.|..
Human   452 QFKPEQMLYRFRYDDGTFYPRNEMQDVISKGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKL 516

  Fly    69 ---LLVLENCRARIQNEERDSEGYVFDL---------------DFKDSP-SERFITRSSAERLAW 114
               |:...:||.|       .|..:|.:               :|||.| ..||.:....|
Human   517 IDWLIAQGDCRTR-------EEAMIFGVGLCDNGFMHHVLEKSEFKDEPLLFRFFSDEEME---- 570

  Fly   115 VQCIEHASSEKLNALIRQLK--EQIVSQSRQPSSGASSSMGNHIDLGMPLEQQMQE---QLQLHG 174
                  .|:.|...:...||  |.::::|....|...|       .|..||.:.:.   :|...|
Human   571 ------GSNMKHRLMKHDLKVVENVIAKSLLIKSNEGS-------YGFGLEDKNKVPIIKLVEKG 622

  Fly   175 QPAEELSVPVPTEVVA---------PFEELDLSELPICETALSCDTLPLDTLGRPPNPQVVCSLL 230
            ..||...:.|..::.|         ||.|:|                              |.|.
Human   623 SNAEMAGMEVGKKIFAINGDLVFMRPFNEVD------------------------------CFLK 657

  Fly   231 PTAGEDCVWREHARTELQERTRTPQFLCTMRFQ-RSAGLSASTRLRFSVFDVRERMTLTAVPLGH 294
            .........|....|:.:|..:.|.....:.|| |..|.|                .:.||..|.
Human   658 SCLNSRKPLRVLVSTKPRETVKIPDSADGLGFQIRGFGPS----------------VVHAVGRGT 706

  Fly   295 AEVALGVIQDTSRLRLPLTSPRGEC----GFITLASWSPDAAVEPGQSGNGPPRSSTQLFDGSAG 355
            ...|.|:            .| |:|    ..|.::..:..:.:....:.....|.:.|  |....
Human   707 VAAAAGL------------HP-GQCIIKVNGINVSKETHASVIAHVTACRKYRRPTKQ--DSIQW 756

  Fly   356 AGGATTSSRRAHRRTQSLPPKLGVRLFVPQQCGLQRV--------------------CSNPRLR- 399
            ...:..|::...:::.|.||  |........|.::.|                    ..|..|.
Human   757 VYNSIESAQEDLQKSHSKPP--GDEAGDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEY 819

  Fly   400 --TYRLHSSLGADISVQETLLESRLCCQLPQQLLSIWIQREKELLQEISGMGELS----GEWRWR 458
              .|...|:.|...:|.|.::|.:....|..::|....:.::..:|..:.:..|:    .:.:.:
Human   820 GVVYEYDSTAGIKCNVVEKMIEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQSK 884

  Fly   459 QMNLLEEHLRLL-------KDYSQAKQNIQQLARDGVSFKRSSAKAD--ESLEFLPVNLHVQRM- 513
            ...|..|.:..|       |.:|:..:|     |...:||::.:|..  .|.:|.|.|.||..|
Human   885 FSALCSERIEHLCQRISSYKKFSRVLKN-----RAWPTFKQAKSKISPLHSSDFCPTNCHVNVME 944

  Fly   514 --WAQNDTLQRRGLLDVVTVGAFTRHDPKGRKCGGLIKLLQESKSWKLEQSNACKVQAANDAVQA 576
              :.:..|          ::|:........||.....|..:.|:..||
Human   945 VSYPKTST----------SLGSAFGVQLDSRKHNSHDKENKSSEQGKL----------------- 982

  Fly   577 TKQLRKEIVELMSQLLQLASRRSSMDMMPLCNQMVARTRTLLNLWEPSIVEEAVAFIERH--RII 639
                                           :.||....|:..:..||.:  ::...:.|  |.:
Human   983 -------------------------------SPMVYIQHTITTMAAPSGL--SLGQQDGHGLRYL 1014

  Fly   640 EEPENVLMEPMSPFRKITQQL-TAL---ELKSPELEDFATPVVAPPDLWPRGQPPLMRSNSWHPS 700
            .:.|:  :|....::|:..:| |||   |:...:::|..:.:...|.|..:....::.::|.:..
Human  1015 LKEED--LETQDIYQKLLGKLQTALKEVEMCVCQIDDLLSSITYSPKLERKTSEGIIPTDSDNEK 1077

  Fly   701 NSSPSSSLDIRAIDSLQHVVKCYNDHLRSLEQGRQPGRQADDEEQEEATYQSLPVAWQTQSEVSA 765
            ....|..:             |:|              .|.||:::                 |.
Human  1078 GERNSKRV-------------CFN--------------VAGDEQED-----------------SG 1098

  Fly   766 GTQIPPSDNPADLSVLQLIDLDEIGRQAQRQRHHQPPAGFLDTKLMSSSPSANYYRPTEEPEPLD 830
            ...|...|:.:|.:                 .:....|.|  |.:.||..|:.::  ::|.:..|
Human  1099 HDTISNRDSYSDCN-----------------SNRNSIASF--TSICSSQCSSYFH--SDEMDSGD 1142

  Fly   831 LTQLNIEASVMCLVSKLKFFCGRCDSPAIRLRHPKAPIKREGFAVAPQQAPDVIAASAASGKQAP 895
            ...|                       ::|:.|.|               .|.|
Human  1143 ELPL-----------------------SVRISHDK---------------QDKI----------- 1158

  Fly   896 NLALDLKPQSVDSDGITTTGSVAVKKGNK---FTDGLDLSMTTDWAAELRPSM---RKLR-HAMD 953
            :..|:.....|||......|...|:..::   .|.|..|.   ::..|:.|.:   ::|| |...
Human  1159 HSCLEHLFSQVDSITNLLKGQAVVRAFDQTKYLTPGRGLQ---EFQQEMEPKLSCPKRLRLHIKQ 1220

  Fly   954 ---RLLKTAR-LMHSVQRLQQDMRCNRLQASIMY-------RRDVCFSQALTALV----SSLMLR 1003
               .|..:.| |..::::..::::|..|.|.:.|       |||:.|.|.|.|.|    ..||..
Human  1221 DPWNLPSSVRTLAQNIRKFVEEVKCRLLLALLEYSDSETQLRRDMVFCQTLVATVCAFSEQLMAA 1285

  Fly  1004 L--------------WGSELDMGYLVMLRDLGPLAYFEGLLT-LYGNEADMWSDMCIAIEDLSAV 1053
            |              |  |....:|..:.:.|.|.:|:.||: ...:|..|..|..:|:.||..|
Human  1286 LNQMFDNSKENEMETW--EASRRWLDQIANAGVLFHFQSLLSPNLTDEQAMLEDTLVALFDLEKV 1348

  Fly  1054 SFQLVRAQGE--VAQTP-TPRITGSRQALEVQL--------PVPEHSLPGNGNSISFKITPVFFN 1107
            ||....::.|  ||..| |.:..||||||:|..        .:|:....|.|    |||.||.|.
Human  1349 SFYFKPSEEEPLVANVPLTYQAEGSRQALKVYFYIDSYHFEQLPQRLKNGGG----FKIHPVLFA 1409

  Fly  1108 IGIN--EKASFAETLGQTKEQHRSNWDNYLRLSQYFGRYRKLGLGSVDTGESLQSLLGFMEQQLR 1170
            ..:.  |...:.:.:...:.|.:.|..:..::.||..:.|...|...::..:..|...::::.:|
Human  1410 QALESMEGYYYRDNVSVEEFQAQINAASLEKVKQYNQKLRAFYLDKSNSPPNSTSKAAYVDKLMR 1474

  Fly  1171 ------------------------ANV---SKNVKILHLAEDACRLMDGLRFTSCKSAKDRTGMA 1208
                                    ||.   :..|.:|.::.:.|..:.......|.|...|..::
Human  1475 PLNALDELYRLVASFIRSKRTAACANTACSASGVGLLSVSSELCNRLGACHIIMCSSGVHRCTLS 1539

  Fly  1209 VTLEQCRVLVREFQLPAKHVPYALSTMRSEGTRMDNVLKNIGKRKYAFNRTQVSFLPAMYR---- 1269
            |||||..:|.|...||.:::..|...||.:|.|:.|..||:|.|    :||..| .|.:|:
Human  1540 VTLEQAIILARSHGLPPRYIMQATDVMRKQGARVQNTAKNLGVR----DRTPQS-APRLYKLCEP 1599

  Fly  1270 -PPVG 1273
             ||.|
Human  1600 PPPAG 1604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42271	NP_996434.2	PH_INPP4A_INPP4B	1..145	CDD:270091	33/161 (20%)
		PH	21..123	CDD:278594	26/134 (19%)
		C2	201..318	CDD:301316	17/117 (15%)
PREX2	NP_079146.2	RhoGEF	27..213	CDD:279015
		PH_Collybistin_ASEF	218..364	CDD:269931
		PH	248..356	CDD:278594
		DEP_1_P-Rex	382..462	CDD:239886	3/9 (33%)
		DEP_2_P-Rex	474..566	CDD:239887	22/98 (22%)
		PDZ_signaling	595..670	CDD:238492	18/111 (16%)
		PDZ_signaling	677..744	CDD:238492	15/95 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1581..1606		10/29 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810