Protein Alignment CG42271 and inpp4a

DIOPT Version :9

• Sequence 1: NP_996434.2
• Gene: CG42271 / 2768892
• FlyBaseID: FBgn0259166
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: XP_012812761.2
• Gene: inpp4a / 780177
• XenbaseID: XB-GENE-1012982
• Length: 972
• Species: Xenopus tropicalis
• Alignment Length: 1141
• Identity: 313/1141 - (27%)
• Similarity: 497/1141 - (43%)
• Gaps: 197/1141 - (17%)

  Fly   166 MQEQLQLHG-QPAEELSVP---VPTEVVAPFEELDLSELPICETALSCDTLPLDTLGRPPNPQVV 226
            ::|....|| :|...:.|.   :...:...|::.|   .||.|.:|:|..|...:|.|.||..|.
 Frog     3 VREHSPRHGARPRSTIDVSSEMMGLSLAGNFQDPD---EPILEFSLACSELTTPSLDRKPNSFVA 64

  Fly   227 CSLLPTAGEDCVWREHARTELQERTRTPQFLCTMRFQRSAGLSASTRLRFSVFDVRERMTLTAVP 291
            .|:  |......|.:||:||:.|.|..|.||.::.|.:.:.::..|:::.||:||::|...|...
 Frog    65 ISV--TTPPQAFWTKHAQTEIIEGTSNPTFLSSIAFFQDSLINQMTQIKLSVYDVKDRSQGTMYL 127

  Fly   292 LGHAEVALGVI--QDTSRLRLPLTSPRGE-CGFITLASWSPDAAVEPGQSGNGPPRSSTQLFDGS 353
            ||..:..:..:  :...||.|||.|...| .|.||:..|..:...:...:....|
 Frog   128 LGFGKFTVKEVLREKNHRLCLPLWSAEQEPVGKITVIGWQMEEKTDQRTAVTRSP---------- 182

  Fly   354 AGAGGATTSSRRAHRRTQSLPPKLGVR---LFVPQQCGLQRVCSNPRLRTYRLHSSLGADISVQE 415
                 .|.:.|......:||...||:|   ..:.:...|:.|......|.||..::.|..:.:.|
 Frog   183 -----DTINGRTVLPVDESLTESLGIRSKYASLRKDTLLKTVFGGAICRMYRFPTTDGNHLRILE 242

  Fly   416 TLLESRLCCQLPQQLLSIWIQREKELLQEISGMGELSGEWRWRQMNLLEEHLRLLKDYSQAKQNI 480
            .:.||.|...:|:|.:.:.::.:...:.|:..:||||..|...:..::.::..::..|.:...|:
 Frog   243 QMAESVLSLHIPRQFVKLLLEEDAARVCELEELGELSPCWENLRRQIVTQYQNIILTYQENMTNL 307

  Fly   481 QQLARDGVSFKRSSAKADESLEFLPVNLHVQRMWAQNDTLQRRGLLDVVTVGAFTRHDPKGRKCG 545
            .|.  .|||||.||.|||:.|||:|.|||:|||..|:::...:. .|:||:||...| .:|.|.|
 Frog   308 HQY--KGVSFKASSLKADKKLEFVPTNLHIQRMRVQDESASDQN-YDIVTIGAPAAH-CQGFKSG 368

  Fly   546 GLIKLL---QESKSWKLEQS--NACK---VQAANDAVQATKQLRKEIVELMSQLLQLASRRSSMD 602
            ||.|.|   :|:|....|:|  .:|.   |....|.::| |::...|..|.:|:...|.|.|
 Frog   369 GLRKQLHKFEEAKKHSFEESCTTSCPQSIVYIPQDIIRA-KEIIAHINTLKTQVSYYAERLS--- 429

  Fly   603 MMPLCNQMVARTRTLLNLWEPSIVEEAVAFIERHRIIEEPENVLMEPMSPFRKITQQLTALELKS 667
                   ..|:.|:...|             ||...|...:...:..:...|.:...:..|....
 Frog   430 -------RAAKDRSANGL-------------ERTLAILADKTRQLVTVCDCRLLANSIHGLNAAR 474

  Fly   668 PELEDFATPVVAPPDLWPRGQPPLMRSNSWHPSNSSPSSSLDIRAIDSLQHVVKCYNDHLRSLEQ 732
            |:                           :..|.:||:|.    .:|  |.:::...|.|.:...
 Frog   475 PD---------------------------YIASKASPTSG----EVD--QVMLRNDQDTLVAKWT 506

  Fly   733 GRQPGRQADDEEQEEATYQSLPVAWQTQSEVSAGTQIPPSDNPADLSVLQLIDLDEIGRQAQRQR 797
            ||.             :..||.|.|..:......:.:..|        |:.| :..:.:..|::|
 Frog   507 GRN-------------SRSSLQVDWHEEEWDKVWSNVEKS--------LECI-IQRVDKLLQKER 549

  Fly   798 HHQPPAGFLDTKLMSSSPSANYYRPTEEPEPLDLTQLNIEASVMCLVSKLKFFCGRCDSPAIRLR 862
            .|              |.|.:           |:.|..|..|     ||
 Frog   550 LH--------------SDSCD-----------DVFQCEISCS-----SK---------------- 568

  Fly   863 HPKAPIKREGFAVAPQQAPDVIAASAASGKQAPNLALDLKPQSVDSDGITTTGSVAVKKGNKFTD 927
              |..::.:.:.:.|..:.|...:|.:|...:|...   .||..:|...:...|..
 Frog   569 --KGNLRNQAYWINPTASDDEALSSPSSSPSSPACH---PPQFTNSSSASEDPSPG--------- 619

  Fly   928 GLDLSMTTDWAAELRPSMRKLRHAMDRLLKTARLMHSVQRLQQDMRCNRLQASIMYRRDVCFSQA 992
                    :|:..|.|.:..|...:..:...|:.......:|.......:..|:.|||||.|.|.
 Frog   620 --------EWSEALYPLLSTLTDCVAMMSDKAKKAMVFLLMQDSAPTIAMYLSLQYRRDVVFCQT 676

  Fly   993 LTALVSSLMLRLWGSELDMGYLVMLRDLGPLAYFEGLLTLYGNEADMWSDMCIAIEDLSAVSFQL 1057
            ||||:...:::|.....|.|:|..|..:|.||.||.||:.||.|..|..||.|.|.||..|:|::
 Frog   677 LTALICGFIIKLRNCLHDNGFLRQLYTIGLLAQFESLLSTYGEELPMLEDMSIGIMDLRNVTFKV 741

  Fly  1058 VRAQGEVAQTPTPRITGSRQALEVQLPVPE---HSLPGNGNS-ISFKITPVFFNIGINEKASFAE 1118
            .:|....:....|.|||:|....|::|:|.   .:||....| :..::.||.||:||||:.:.||
 Frog   742 TQAISNASSDMLPVITGNRDGFNVRIPLPSALFDALPREIQSGMLLRVQPVLFNVGINEQQTLAE 806

  Fly  1119 TLGQTKEQHRSNWDNYLRLSQYFGRYRKL----GLGSVDTGESLQSLLGFMEQQLRANVSKNVKI 1179
            ..|.|..|...|.::.:||:.|:.:::::    .|....:...|..||.|:.|.:.|..:|||.|
 Frog   807 KFGDTSLQELINMESLVRLNSYYEQFKEVLPEDFLPRSRSQTCLPELLRFLGQNVHARKNKNVDI 871

  Fly  1180 LHLAEDACRLMDGLRFTSCKSAKDRTGMAVTLEQCRVLVREFQLPAKHVPYALSTMRSEGTRMDN 1244
            |..|.:.||.::|:||||||||||||.|:||||||.:|..|..:..:....||..|||||.|.:|
 Frog   872 LWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRREN 936

  Fly  1245 VLKNIGKRKYAFNRTQVSFLPAMYRPPVGSYGKAQT 1280
            .:||:|.||||||..|:...|..||||.|:|||.:|
 Frog   937 TMKNVGCRKYAFNSLQLKAFPKHYRPPEGTYGKVET 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42271	NP_996434.2	PH_INPP4A_INPP4B	1..145	CDD:270091
		PH	21..123	CDD:278594
		C2	201..318	CDD:301316	39/118 (33%)
inpp4a	XP_012812761.2	C2A_Copine	39..150	CDD:176013	36/112 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	391	1.000	Domainoid score	I780
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	391	1.000	Inparanoid score	I1945
OMA	1	1.010	-	-		QHG46978
OrthoDB	1	1.010	-	-		D129165at2759
OrthoFinder	1	1.000	-	-		FOG0002887
OrthoInspector	1	1.000	-	-		otm47442
Panther	1	1.100	-	-	O	PTHR12187
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5733
SonicParanoid	1	1.000	-	-		X1907
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110