DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42271 and INPP4A

DIOPT Version :9

Sequence 1:	NP_996434.2	Gene:	CG42271 / 2768892	FlyBaseID:	FBgn0259166	Length:	1280	Species:	Drosophila melanogaster
Sequence 2:	XP_006712562.1	Gene:	INPP4A / 3631	HGNCID:	6074	Length:	994	Species:	Homo sapiens

Alignment Length:	1128	Identity:	301/1128 - (26%)
Similarity:	472/1128 - (41%)	Gaps:	229/1128 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 QEQLQLHGQPAEELSVPVPTEVVAPFEELDLS------ELPICETALSCDTLPLDTLGRPPNPQV 225
            :|....||..|..:......:|.|....|.|:      :.||.|.:|:|..|...:|.|.||..|
Human     4 REHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSLDRKPNSFV 68

  Fly   226 VCSLLPTAGEDCVWREHARTELQERTRTPQFLCTMRFQRSAGLSASTRLRFSVFDVRERMTLTAV 290
            ..|:  |......|.:||:||:.|.|..|.||.::.|.:.:.::..|:::.||:||::|...|..
Human    69 AVSV--TTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVYDVKDRSQGTMY 131

  Fly   291 PLGHAE-VALGVIQDT-SRLRLPLTSPRGE-CGFITLASWSPDAAVEPGQSGNGPPRSSTQLFDG 352
            .||... :...::||. .||.|.|.|...: .|.||:..|..:.     :|...||  .|:..|
Human   132 LLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEE-----KSDQRPP--VTRSVD- 188

  Fly   353 SAGAGGATTSSRRAHRRTQSLPPKLGVR---LFVPQQCGLQRVCSNPRLRTYRLHSSLGADISVQ 414
                   |.:.|......:||...||:|   ..:.:...|:.|......|.||..::.|..:.:.
Human   189 -------TVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDGNHLRIL 246

  Fly   415 ETLLESRLCCQLPQQLLSIWIQREKELLQEISGMGELSGEWRWRQMNLLEEHLRLLKDYSQAKQN 479
            |.:.||.|...:|:|.:.:.::.:...:.|:..:||||..|...:..::.::..::..|.:...:
Human   247 EQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTD 311

  Fly   480 IQQLARDGVSFKRSSAKADESLEFLPVNLHVQRMWAQNDTLQRRGLLDVVTVGAFTRHDPKGRKC 544
            :.|..  |.|||.||.|||:.|||:|.|||:|||..|:|....:. .|:||:||...| .:|.|.
Human   312 LHQYR--GPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQN-YDIVTIGAPAAH-CQGFKS 372

  Fly   545 GGLIKLL---QESKSWKLEQ---SNACK--VQAANDAVQATKQLRKEIVELMSQLLQLASRRSSM 601
            |||.|.|   :|:|....|:   |:.|:  :....|.|:| |::..:|..|.:|:...|.|.|
Human   373 GGLRKKLHKFEETKKHSFEECCTSSGCQSIIYIPQDVVRA-KEIIAQINTLKTQVSYYAERLS-- 434

  Fly   602 DMMPLCNQMVARTRTLLNLWEPSIVEEAVAFIERHRIIEEPENVLMEPMSPFRKITQQLTALELK 666
                    ..|:.|:...|      |..:|.:.                   .|..|.:|..:.|
Human   435 --------RAAKDRSATGL------ERTLAILA-------------------DKTRQLVTVCDCK 466

  Fly   667 SPELEDFATPVVAPPDLWPRGQPPLMRSNSWH----------PSNSSPSSSLDIRAIDSLQHVVK 721
                                     :.:||.|          .|.:||:|:      :..|.:::
Human   467 -------------------------LLANSIHGLNAARPDYIASKASPTST------EEEQVMLR 500

  Fly   722 CYNDHLRSLEQGRQPGRQADDEEQEEATYQSLPVAWQTQSEVSAGTQIPPSDNPADLSVLQLIDL 786
            ...|.|.:...||.             :..||.|.|..:........:..|        |:.| :
Human   501 NDQDTLMARWTGRN-------------SRSSLQVDWHEEEWEKVWLNVDKS--------LECI-I 543

  Fly   787 DEIGRQAQRQRHHQ-------PPAGFLDTKLMSSSPSANYYRPTEEPEPLDLTQLNIEASVMCLV 844
            ..:.:..|::|.|.       |.||...:|..:....|.:.|| |:|
Human   544 QRVDKLLQKERLHGEGCEDVFPCAGSCTSKKGNPDSHAYWIRP-EDP------------------ 589

  Fly   845 SKLKFFCGRCDSPAIRLRHPKAPIKREGFAVAPQQAPDVIAASAASGKQAPNLALDLKPQSVDSD 909
                 ||....||                      .|..:.::|..    |:|.....|...:|.
Human   590 -----FCDVPSSP----------------------CPSTMPSTACH----PHLTTHCSPPPEESS 623

  Fly   910 GITTTGSVAVKKGNKFTDGLDLSMTTDWAAELRPSMRKLRHAMDRLLKTARLMHSVQRLQQDMRC 974
                                    ..:|:..|.|.:..|...:..:...|:.......:|.....
Human   624 ------------------------PGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPT 664

  Fly   975 NRLQASIMYRRDVCFSQALTALVSSLMLRLWGSELDMGYLVMLRDLGPLAYFEGLLTLYGNEADM 1039
            .....|:.|||||.|.|.||||:...:::|.....|.|:|..|..:|.||.||.||:.||.|..|
Human   665 IATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLSTYGEELAM 729

  Fly  1040 WSDMCIAIEDLSAVSFQLVRAQGEVAQTPTPRITGSRQALEVQLPVPE---HSLPGNGNS-ISFK 1100
            ..||.:.|.||..|:|::.:|....:....|.|||:|....|::|:|.   .:||....| :..:
Human   730 LEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLR 794

  Fly  1101 ITPVFFNIGINEKASFAETLGQTKEQHRSNWDNYLRLSQYFGRYRKL----GLGSVDTGESLQSL 1161
            :.||.||:||||:.:.||..|.|..|...|.::.:||:.||.:::::    .|....:...|..|
Human   795 VQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPEL 859

  Fly  1162 LGFMEQQLRANVSKNVKILHLAEDACRLMDGLRFTSCKSAKDRTGMAVTLEQCRVLVREFQLPAK 1226
            |.|:.|.:.|..:|||.||..|.:.||.::|:||||||||||||.|:||||||.:|..|..:..:
Human   860 LRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQ 924

  Fly  1227 HVPYALSTMRSEGTRMDNVLKNI 1249
            ....||..|||.|||.....||:
Human   925 VFTQALECMRSIGTREVVTQKNL 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42271	NP_996434.2	PH_INPP4A_INPP4B	1..145	CDD:270091
		PH	21..123	CDD:278594
		C2	201..318	CDD:301316	40/118 (34%)
INPP4A	XP_006712562.1	C2A_Copine	44..157	CDD:176013	39/114 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	379	1.000	Domainoid score	I853
eggNOG	1	0.900	-	-		E1_KOG4428
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2871
Inparanoid	1	1.050	379	1.000	Inparanoid score	I2073
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46978
OrthoDB	1	1.010	-	-		D129165at2759
OrthoFinder	1	1.000	-	-		FOG0002887
OrthoInspector	1	1.000	-	-		otm40269
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12187
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5733
SonicParanoid	1	1.000	-	-		X1907
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.970