DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42271 and R01H10.7

DIOPT Version :9

Sequence 1:	NP_996434.2	Gene:	CG42271 / 2768892	FlyBaseID:	FBgn0259166	Length:	1280	Species:	Drosophila melanogaster
Sequence 2:	NP_001366686.1	Gene:	R01H10.7 / 187517	WormBaseID:	WBGene00010975	Length:	793	Species:	Caenorhabditis elegans

Alignment Length:	1063	Identity:	218/1063 - (20%)
Similarity:	375/1063 - (35%)	Gaps:	377/1063 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 ELQERTRTPQFLCTMRFQRSAGLSASTRLRFSV--FDVRERMTLTAVPLGHAEVALGVIQDTSRL 308
            :|:|.:.|.:|...:.|...|     ..|..||  .::||:..:......| ::|...:.:.:
Worm    73 KLEENSDTAKFTFLLTFTDPA-----ENLEISVESEELREQWMIKLATCSH-QMARAELDELA-- 129

  Fly   309 RLPLTSPRGECGFITLASWSPDAAVEPGQSGNG---PPRSSTQLFDGSAGAGGATTSSRRAHRRT 370
                      ..|.|:   ||.|:  .|...:|   |..|:.|.|..||
Worm   130 ----------YKFYTM---SPSAS--SGGDSDGVIDPKTSAFQNFYLSA---------------- 163

  Fly   371 QSLPPKLGVRLFVPQQCGLQRVCSNPRLRTYRLHSSLGADISVQETLLESRLCCQLPQQLLSIWI 435
               |.::.....:.||..|      |..|           :.|:|.:.|::|...||::::.  :
Worm   164 ---PLRIAHNFAISQQNNL------PARR-----------VIVEECMWETKLSIILPKEIIK--L 206

  Fly   436 QREKELLQEISGMGELSGEWRWRQMNL--LEEHLRLLKDYSQAKQNIQQL--ARDGVSFKRSSAK 496
            .|:|  :.|.||:.| |....|.|.::  |.|.:|.|:..|:..:...:.  |..|.:|::|..|
Worm   207 NRKK--ISEFSGLLE-SRLKTWPQSSIPGLHEVIRQLRGMSETYEQCFEFVDAYSGPNFRKSVEK 268

  Fly   497 ADESLEFLPVNLHVQRMWAQNDTLQRRGLLDVVTVGA-----FTRHDPKGRKCGGLIKLLQ--ES 554
            ...:...:|.|||: ..:..|.:.:|    |.:|.|:     :..|:      ||::||..  :.
Worm   269 TRVAFGLVPTNLHI-HSYEINSSDKR----DFITAGSASAIPYRYHN------GGILKLYSQLDV 322

  Fly   555 KSWKLEQSNACKVQAANDAVQATKQLRKEIVELMSQLLQLASRRSSMDMMPLCNQMVARTRTLLN 619
            .|:..:.:...|.||..|       |:|.|.||
Worm   323 PSYNFDYTFWKKRQALLD-------LKKTIGEL-------------------------------- 348

  Fly   620 LWEPSIVEEAVAFIERHRIIEE--------PENVLMEPMSPFRKITQQLTALELKSPELEDFATP 676
                           .|:|.:|        |:.:.::..:..:::.:.|..:.:..|::|
Worm   349 ---------------SHKIEKEWKIAKFGSPDKICLQVHAGIKQVYEGLKDVLISLPDVE----- 393

  Fly   677 VVAPPDLWPRGQPPLMRSNSWHPSNSSPSSSLDIRAIDSLQHVVKCYNDHLRSLEQGRQPGRQAD 741
                                              |..:.|                       .:
Worm   394 ----------------------------------RCSELL-----------------------LE 401

  Fly   742 DEEQEEATYQSLPVAWQTQSEVSAGTQIPPSDNPADLSVLQLIDLDEIGRQAQRQRHHQPPAGFL 806
            :|::.|.:...:|           .|::                .|.|..|..|          |
Worm   402 EEKRREESGAKMP-----------ETRV----------------YDNIQNQIDR----------L 429

  Fly   807 DTKLMSSSPSANYYRPTEEPEPLDLTQLNIEASVMCLVSKLKFFCGRCDSPAIRLRHPKAPIKRE 871
            |...:|                     ||.:.:|:..::                   :||.:||
Worm   430 DAMSVS---------------------LNTKIAVIDTLN-------------------EAPHERE 454

  Fly   872 GFAVAPQQAPDVIAASAASGKQAPNLALDLKPQSVDSDGITTTGSVAVKKGNKFTDGLDLSMTTD 936
                          |...:.:||.:..||:
Worm   455 --------------ACEKNTRQAISTCLDI----------------------------------- 470

  Fly   937 WAAELRPSMRKLRHAMDRLLKTARLMHSVQRLQQDMRCNRLQASIMYRRDVCFSQALTALVSSLM 1001
                       |....|.:|: ::|...|:.||:....: ....|:.|.|...|||:|...::::
Worm   471 -----------LLALADTILE-SQLFSLVKSLQKPATAH-AYFHILIRTDFVLSQAITIATTAIL 522

  Fly  1002 LRLWGSE--LDMGYLVMLRDLGPLAYFEGLLTLYGNEADMWSDMCIAIEDL-SAVSFQLVRAQGE 1063
            .|:...|  ....:|:::         ...|:.||:|..|..|...|.:.| ..|.|:||||...
Worm   523 NRIQKREKPFTQDFLLVV---------FSFLSAYGDERGMIEDAVEAWKSLEQRVRFRLVRAPSA 578

  Fly  1064 VAQTPTPRITGSRQALEVQLPVPE---HSLPGNGNSIS-FKITPVFFNIGINEKASFAETLGQTK 1124
            |.:|..|.|.|:|.:|:|.:|:|.   ..||.:....| |.:|..:||:|:|.:|:|.::.|...
Worm   579 VCRTCIPMIQGTRSSLKVAIPLPHDYFDELPDHIKWTSEFTVTTSYFNLGVNHEATFGQSFGGVS 643

  Fly  1125 EQHRSNWDNYLRLSQYFGRYRKLGLGSVDTGESLQSLLGFMEQQLRANVSKNVKILHLAEDACRL 1189
            .:...|.|...:|:.:..|..    .|....|::..::..:..:   ...||:.:...|..||..
Worm   644 FESIVNQDAADKLNVFANRNE----ASPRAREAVMEVVNEVSSE---PSRKNLTMFDWAMTACEQ 701

  Fly  1190 MDGLRFTSCKSAKDRTGMAVTLEQCRVLVREFQLPAKHVPYALSTMRSEGTRMDNVLKNIGKRKY 1254
            :.|....||||.|||||||.||||.|||..........|...:|::|.||.|.:|..||:||..|
Worm   702 LGGEAVISCKSGKDRTGMASTLEQGRVLRETCGFNTAQVSEVVSSLRKEGVRRENCRKNVGKPVY 766

  Fly  1255 AFNRTQVSFLPAMYRPPVGSYGK 1277
            :|:..|:.|||...|||.|:|.:
Worm   767 SFSPFQMHFLPKALRPPSGTYSQ 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42271	NP_996434.2	PH_INPP4A_INPP4B	1..145	CDD:270091
		PH	21..123	CDD:278594
		C2	201..318	CDD:301316	13/73 (18%)
R01H10.7	NP_001366686.1	PH	<41..118	CDD:214574	11/49 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166366
Domainoid	1	1.000	173	1.000	Domainoid score	I2207
eggNOG	1	0.900	-	-		E1_KOG4428
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	174	1.000	Inparanoid score	I2713
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129165at2759
OrthoFinder	1	1.000	-	-		FOG0002887
OrthoInspector	1	1.000	-	-		oto17364
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12187
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5733
SonicParanoid	1	1.000	-	-		X1907
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.890