Protein Alignment CG42271 and inpp-4B

DIOPT Version :10

• Sequence 1: NP_996434.2
• Gene: CG42271 / 2768892
• FlyBaseID: FBgn0259166
• Length: 1280
• Species: Drosophila melanogaster
• Sequence 2: NP_001366686.1
• Gene: inpp-4B / 187517
• WormBaseID: WBGene00010975
• Length: 793
• Species: Caenorhabditis elegans
• Alignment Length: 1063
• Identity: 218/1063 - (20%)
• Similarity: 375/1063 - (35%)
• Gaps: 377/1063 - (35%)

  Fly   246 ELQERTRTPQFLCTMRFQRSAGLSASTRLRFSV--FDVRERMTLTAVPLGHAEVALGVIQDTSRL 308
            :|:|.:.|.:|...:.|...|     ..|..||  .::||:..:......| ::|...:.:.:
 Worm    73 KLEENSDTAKFTFLLTFTDPA-----ENLEISVESEELREQWMIKLATCSH-QMARAELDELA-- 129

  Fly   309 RLPLTSPRGECGFITLASWSPDAAVEPGQSGNG---PPRSSTQLFDGSAGAGGATTSSRRAHRRT 370
                      ..|.|:   ||.|:  .|...:|   |..|:.|.|..||
 Worm   130 ----------YKFYTM---SPSAS--SGGDSDGVIDPKTSAFQNFYLSA---------------- 163

  Fly   371 QSLPPKLGVRLFVPQQCGLQRVCSNPRLRTYRLHSSLGADISVQETLLESRLCCQLPQQLLSIWI 435
               |.::.....:.||..|      |..|           :.|:|.:.|::|...||::::.  :
 Worm   164 ---PLRIAHNFAISQQNNL------PARR-----------VIVEECMWETKLSIILPKEIIK--L 206

  Fly   436 QREKELLQEISGMGELSGEWRWRQMNL--LEEHLRLLKDYSQAKQNIQQL--ARDGVSFKRSSAK 496
            .|:|  :.|.||:.| |....|.|.::  |.|.:|.|:..|:..:...:.  |..|.:|::|..|
 Worm   207 NRKK--ISEFSGLLE-SRLKTWPQSSIPGLHEVIRQLRGMSETYEQCFEFVDAYSGPNFRKSVEK 268

  Fly   497 ADESLEFLPVNLHVQRMWAQNDTLQRRGLLDVVTVGA-----FTRHDPKGRKCGGLIKLLQ--ES 554
            ...:...:|.|||: ..:..|.:.:|    |.:|.|:     :..|:      ||::||..  :.
 Worm   269 TRVAFGLVPTNLHI-HSYEINSSDKR----DFITAGSASAIPYRYHN------GGILKLYSQLDV 322

  Fly   555 KSWKLEQSNACKVQAANDAVQATKQLRKEIVELMSQLLQLASRRSSMDMMPLCNQMVARTRTLLN 619
            .|:..:.:...|.||..|       |:|.|.||
 Worm   323 PSYNFDYTFWKKRQALLD-------LKKTIGEL-------------------------------- 348

  Fly   620 LWEPSIVEEAVAFIERHRIIEE--------PENVLMEPMSPFRKITQQLTALELKSPELEDFATP 676
                           .|:|.:|        |:.:.::..:..:::.:.|..:.:..|::|
 Worm   349 ---------------SHKIEKEWKIAKFGSPDKICLQVHAGIKQVYEGLKDVLISLPDVE----- 393

  Fly   677 VVAPPDLWPRGQPPLMRSNSWHPSNSSPSSSLDIRAIDSLQHVVKCYNDHLRSLEQGRQPGRQAD 741
                                              |..:.|                       .:
 Worm   394 ----------------------------------RCSELL-----------------------LE 401

  Fly   742 DEEQEEATYQSLPVAWQTQSEVSAGTQIPPSDNPADLSVLQLIDLDEIGRQAQRQRHHQPPAGFL 806
            :|::.|.:...:|           .|::                .|.|..|..|          |
 Worm   402 EEKRREESGAKMP-----------ETRV----------------YDNIQNQIDR----------L 429

  Fly   807 DTKLMSSSPSANYYRPTEEPEPLDLTQLNIEASVMCLVSKLKFFCGRCDSPAIRLRHPKAPIKRE 871
            |...:|                     ||.:.:|:..::                   :||.:||
 Worm   430 DAMSVS---------------------LNTKIAVIDTLN-------------------EAPHERE 454

  Fly   872 GFAVAPQQAPDVIAASAASGKQAPNLALDLKPQSVDSDGITTTGSVAVKKGNKFTDGLDLSMTTD 936
                          |...:.:||.:..||:
 Worm   455 --------------ACEKNTRQAISTCLDI----------------------------------- 470

  Fly   937 WAAELRPSMRKLRHAMDRLLKTARLMHSVQRLQQDMRCNRLQASIMYRRDVCFSQALTALVSSLM 1001
                       |....|.:|: ::|...|:.||:....: ....|:.|.|...|||:|...::::
 Worm   471 -----------LLALADTILE-SQLFSLVKSLQKPATAH-AYFHILIRTDFVLSQAITIATTAIL 522

  Fly  1002 LRLWGSE--LDMGYLVMLRDLGPLAYFEGLLTLYGNEADMWSDMCIAIEDL-SAVSFQLVRAQGE 1063
            .|:...|  ....:|:::         ...|:.||:|..|..|...|.:.| ..|.|:||||...
 Worm   523 NRIQKREKPFTQDFLLVV---------FSFLSAYGDERGMIEDAVEAWKSLEQRVRFRLVRAPSA 578

  Fly  1064 VAQTPTPRITGSRQALEVQLPVPE---HSLPGNGNSIS-FKITPVFFNIGINEKASFAETLGQTK 1124
            |.:|..|.|.|:|.:|:|.:|:|.   ..||.:....| |.:|..:||:|:|.:|:|.::.|...
 Worm   579 VCRTCIPMIQGTRSSLKVAIPLPHDYFDELPDHIKWTSEFTVTTSYFNLGVNHEATFGQSFGGVS 643

  Fly  1125 EQHRSNWDNYLRLSQYFGRYRKLGLGSVDTGESLQSLLGFMEQQLRANVSKNVKILHLAEDACRL 1189
            .:...|.|...:|:.:..|..    .|....|::..::..:..:   ...||:.:...|..||..
 Worm   644 FESIVNQDAADKLNVFANRNE----ASPRAREAVMEVVNEVSSE---PSRKNLTMFDWAMTACEQ 701

  Fly  1190 MDGLRFTSCKSAKDRTGMAVTLEQCRVLVREFQLPAKHVPYALSTMRSEGTRMDNVLKNIGKRKY 1254
            :.|....||||.|||||||.||||.|||..........|...:|::|.||.|.:|..||:||..|
 Worm   702 LGGEAVISCKSGKDRTGMASTLEQGRVLRETCGFNTAQVSEVVSSLRKEGVRRENCRKNVGKPVY 766

  Fly  1255 AFNRTQVSFLPAMYRPPVGSYGK 1277
            :|:..|:.|||...|||.|:|.:
 Worm   767 SFSPFQMHFLPKALRPPSGTYSQ 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42271	NP_996434.2	PH_INPP4A_INPP4B	1..145	CDD:270091
		C2	201..318	CDD:472691	13/73 (18%)
inpp-4B	NP_001366686.1	PH	<41..118	CDD:214574	11/49 (22%)