DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42271 and Inpp4b

DIOPT Version :9

Sequence 1:	NP_996434.2	Gene:	CG42271 / 2768892	FlyBaseID:	FBgn0259166	Length:	1280	Species:	Drosophila melanogaster
Sequence 2:	NP_446369.1	Gene:	Inpp4b / 116699	RGDID:	620470	Length:	942	Species:	Rattus norvegicus

Alignment Length:	1137	Identity:	266/1137 - (23%)
Similarity:	445/1137 - (39%)	Gaps:	303/1137 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 MPLEQQMQEQLQLHGQPAEELSVPVPTEVVAPFEELDLSEL------PICETALSCDTLPLDTLG 218
            |.::::...:...|..||.:.:.|         |::..:.:      |..|..|:|..|......
  Rat     1 MEIKEEGTSEEGQHFLPAAQANDP---------EDIQFTSIQKSPNEPQLEFILACKDLVAPVSD 56

  Fly   219 RPPNPQVVCSLLPTAGEDCVWREHARTELQERTRTPQFLCTMRFQRSAGLSASTRLRFSVFDVRE 283
            |..|..|..|::... |..:.| ::.||:.|.|:.|.||..:.|.....:...||::.:|:||::
  Rat    57 RKLNTVVQVSVIHPV-EQTLTR-YSSTEIVEGTKDPLFLTGVTFPSDYPIYEETRIKLTVYDVKD 119

  Fly   284 R----MTLTAVP-------------LGHAEVALGVIQDTSRLRLPL---TSPRGE-CGFITLASW 327
            :    :..:.:|             ||.|...:|.:..:....|.|   ||..|: .|.|.:
  Rat   120 KPHDTIRTSVLPEHKDPPPEVARSFLGCASFKVGELLKSKEQLLSLSLRTSDGGKVVGTIEV--- 181

  Fly   328 SPDAAVEPGQSGNGPPRSSTQLFDGSAGAGGATTSSRRAHRRTQSLPPKLGVRLFVPQQCGLQRV 392
               :.|:.|:..:|.....|....|...|....:::..:....::||             .:..|
  Rat   182 ---SLVKMGEIEDGDTDHITTDVQGQKCALVYDSTAPESLSGKENLP-------------FMNAV 230

  Fly   393 CSNPRLRTYRLHSSLGADISVQETLLESRLCCQLPQQLLSIWIQREKELLQEISGMGELSGEWRW 457
            ..||..:.||..:|....:.::|.:.||.|...:|::|:|:.|:.:....||:..:|:||..|..
  Rat   231 LRNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQELKELGDLSPHWDN 295

  Fly   458 RQMNLLEEHLRLLKDYSQAKQNIQQLARD-GVSFKRSSAKADESLEFLPVNLHVQRMWAQNDTLQ 521
            .:.|:|....:::..|...   :.:|::: |.|||.||:|.:::|||:|:|||:|||...:..|
  Rat   296 LRNNVLSHCDQMVTMYQDI---LTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHL- 356

  Fly   522 RRGLLDVVTVGAFTRHDPKGRKCGGLIKLLQESKSWK---------LEQSNACKVQAANDAVQAT 577
            :..|.||:||||...|. :|.|.|||.|||...::.:         ....|..|   |.:.:.:.
  Rat   357 KDALYDVITVGAPAAHF-QGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAK---AKEVLSSI 417

  Fly   578 KQLRKEIVELMSQLLQLASRRSSMDMMPLCNQMVARTRTLLNLWEPSIVEEAVAFIERHRIIEEP 642
            .||:..:......||..||:.|...:......:..:|...::.::..:|..|:..:...|    |
  Rat   418 NQLQPLVATHADLLLTSASQHSPDSLRSSLKLLSEKTELFVHAFKDQLVRSALLALYTAR----P 478

  Fly   643 ENVLMEPMSPFRKITQQLTALELKSPELEDFATPVVAPPDLWPRGQPPLMRSNSWHPSNSSPSSS 707
            ..:|.:|.||  |::.:..:.:..||:
  Rat   479 GGILRKPPSP--KVSTEEKSSQHDSPQ-------------------------------------- 503

  Fly   708 LDIRAIDSLQHVVKCYNDHLRSLEQGRQPGRQADDEEQEEATYQSLPVAWQTQSEVSAGTQIPPS 772
             .:|..||:.|    ::|:               |||:           |
  Rat   504 -QLRRQDSIPH----HSDY---------------DEEE-----------W--------------- 522

  Fly   773 DNPADLSVLQLIDLDEIGRQAQRQRHHQPPAGFLDTKLMSSSPSANYYRPTEEPEPLDLTQLNIE 837
                                                                     |....|:.
  Rat   523 ---------------------------------------------------------DRVWANVG 530

  Fly   838 ASVMCLVSKLKFFCGRCDSPAIRLRHPKAPIKREGFAVAPQQAPDVIAASAASGKQAPNLALDLK 902
            .|:.|:::|:.....|
  Rat   531 KSLNCIIAKVDKLIER------------------------------------------------- 546

  Fly   903 PQSVDSDGITTTGSVAVKKGN---KFTDGLDLSMTTDWAAELRPSMRKLRHAMDRLLKTARLMHS 964
                ||....:||..:.|.|:   ...|.|......||..:|.|.:..|:..|..::..|:...:
  Rat   547 ----DSRNDKSTGGDSSKDGDADPNLEDSLTSHPREDWYEQLHPLILTLKECMAEVVNRAKQSLT 607

  Fly   965 VQRLQQDMRCNRLQASIM--YRRDVCFSQALTALVSSLMLRLWGSELDMGYLVMLRDLGPLAYFE 1027
            ...||:  ....|...:|  .|||:.|||||..||...:::|..|..|.|:|..|..:|.:..:|
  Rat   608 FVLLQE--LAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTSLHDPGFLQQLHTVGLIVQYE 670

  Fly  1028 GLLTLYGNEADMWSDMCIAIEDLSAVSFQLVRAQGEVAQTPTPRITGSRQ--ALEVQLPVPE-HS 1089
            |||:.|.:|..|..||.:.|.||..|:|::..|   .:....|.:||.|:  .:||:||... .|
  Rat   671 GLLSTYSDEIGMLEDMAVGISDLRKVAFKITEA---TSNDVLPVLTGRREHYVVEVKLPATVFES 732

  Fly  1090 LPGNGNSISFK------ITPVFFNIGINEKASFAETLGQTKEQHRSNWDNYLRLSQYFGRY-RKL 1147
            ||     :..|      :.||.||:||||:.:.||..|....|...|.:|:..:.:|:..: .|:
  Rat   733 LP-----LQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELVQEYYSIFMEKM 792

  Fly  1148 G---LGSVDTGESLQSLLGFMEQQLRANVSKNVKILHLAEDACRLMDGLRFTSCKSAKDRTGMAV 1209
            .   :........|:.||..:.|.::|...|||:|:.||...||.::|:|||.||||||||.|:|
  Rat   793 PPDYISHFQEQNDLKGLLDNLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSV 857

  Fly  1210 TLEQCRVLVREFQLPAKHVPYALSTMRSEGTR 1241
            |||||.:|..|.||.......||..|||..|:
  Rat   858 TLEQCSILRDEHQLHKDFFIRALDCMRSRQTQ 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42271	NP_996434.2	PH_INPP4A_INPP4B	1..145	CDD:270091
		PH	21..123	CDD:278594
		C2	201..318	CDD:301316	33/136 (24%)
Inpp4b	NP_446369.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		4/21 (19%)
		C2A_Copine	39..175	CDD:176013	34/137 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..516		11/79 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..575		7/26 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345227
Domainoid	1	1.000	384	1.000	Domainoid score	I786
eggNOG	1	0.900	-	-		E1_KOG4428
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	384	1.000	Inparanoid score	I1964
OMA	1	1.010	-	-		QHG46978
OrthoDB	1	1.010	-	-		D129165at2759
OrthoFinder	1	1.000	-	-		FOG0002887
OrthoInspector	1	1.000	-	-		otm44395
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12187
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1907
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.870