DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42271 and Prex2

DIOPT Version :9

Sequence 1:	NP_996434.2	Gene:	CG42271 / 2768892	FlyBaseID:	FBgn0259166	Length:	1280	Species:	Drosophila melanogaster
Sequence 2:	XP_006495504.1	Gene:	Prex2 / 109294	MGIID:	1923385	Length:	1617	Species:	Mus musculus

Alignment Length:	1445	Identity:	277/1445 - (19%)
Similarity:	476/1445 - (32%)	Gaps:	462/1445 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 RFDKEGLLIITDRQEGFLWRSSEVR------VERWCKLRGNLLFYLKDKD-----PKSAVAG--- 68
            :|..|.:|......:|..:..||::      |..:|:|.......::|||     .||.|..
Mouse   444 QFKPEQMLYRFRYDDGTFYPRSEMQDVISKGVRLYCRLHSLFTPVVRDKDYHLRTYKSVVMANKL 508

  Fly    69 ---LLVLENCRARIQNEERDSEGYVFDL---------------DFKDSP-SERFITRSSAERLAW 114
               |:...:||.|       .|..:|.:               :|||.| ..||......|
Mouse   509 IDWLIAQGDCRTR-------EEAMIFAVGLCDNGFMHHVLEKSEFKDEPLLFRFFADEEME---- 562

  Fly   115 VQCIEHASSEKLNALIRQLK--EQIVSQSRQPSSGASSSMGNHIDLGMPLEQQMQEQLQLHGQPA 177
                  .|:.|...:...||  |.::::|....|...|       .|..||.:.:
Mouse   563 ------GSNMKHRLMKHDLKVVENVIAKSLLIKSNEGS-------YGFGLEDKNK---------- 604

  Fly   178 EELSVPVPTEVVAPFEELDLSELPICETALSCDTLPLDTLGRPPNPQVVCSLLPTAGEDCVWREH 242
                  ||  ::...|:...:|:...|.......:..|.:...|.|:|.|.|..........|..
Mouse   605 ------VP--IIKLVEKGSNAEMAGMEVGKKIFAINGDLVFLRPFPEVDCFLKSCLNSRKPLRVL 661

  Fly   243 ARTELQERTRTPQFLCTMRFQ-RSAGLSASTRLRFSVFDVRERMTLTAVPLGHAEVALGV----- 301
            ..|:.:|..:.|.....:.|| |..|.|                .:.||..|....|.|:
Mouse   662 VSTKPRETVKIPDSADGLGFQIRGFGPS----------------VVHAVGRGTVAAAAGLHPGQC 710

  Fly   302 IQDTSRLRLPLTSPRGECGFITLA------------SW---SPDAAVEPGQSGNGPPRSSTQLFD 351
            |...:.:.:...:.......:|..            .|   |.::|.|..|..:..|...
Mouse   711 IIKVNGINVSKETHASVIAHVTACRKYKRPMKQDSIQWVYDSLESAQEDIQKSHSKPPGD----- 770

  Fly   352 GSAGAGGATTSSRRAHRRTQSLPPKLGVRLFVP-QQCGLQRVCSNPRLR---TYRLHSSLGADIS 412
               |||.|...      :.:.:..|......:. ::..:.....|..|.   .|...|:.|...:
Mouse   771 ---GAGDAFEC------KVEDVIDKFNTMAIIDGKKEHVSLTVDNVHLEYGVVYEYDSTAGTKCN 826

  Fly   413 VQETLLESRLCCQLPQQLLSIWIQREKELLQEISGMGEL----SGEWRWRQMNLLEEHL------ 467
            |.|.::|.:....|..::|....:.::..:|..:.:..|    :.:.:.:..::..|.:
Mouse   827 VVEKMVEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIATDLQSKFTSMCSERIEHVCHR 891

  Fly   468 --------RLLKD-----YSQAKQNIQQLARDGVSFKRSSAKADESLEFLPVNLHVQRM---WAQ 516
                    |:||:     :.|||..|..|               .|.:|.|.|.||..|   :.:
Mouse   892 ISSYGRFSRVLKNRAWPTFKQAKPKISPL---------------HSSDFCPTNCHVNVMEVSYPK 941

  Fly   517 NDTLQRRGLLDVVTVG-AF---------TRHDPKGRKCGGLIKLLQESKS---WKLEQSNACKVQ 568
            ..|          ::| ||         ..||             :|:||   .||  |....:|
Mouse   942 TST----------SLGSAFGVQLDSRKHNSHD-------------KENKSVEPGKL--SPMVYIQ 981

  Fly   569 AANDAVQATKQL---RKEIVELMSQLLQLASRRSSMDMMPLCNQMVARTRTLLNLWEPSIVEEAV 630
            .....:.|...|   .|:     ...||...:...::...:.::::.:.:|.|...|.|:.:
Mouse   982 HTITTMAAPSGLSLGHKD-----GHGLQYLLKEEDLETQDIYHKLLGKLQTALKEVEMSVCQ--- 1038

  Fly   631 AFIERHRIIEEPENVLMEPMSPFRKITQQLTALELKSPELEDFATPVVAPPDLWPRGQPPLMRSN 695
                                     |...|:::.. ||:||...|..|.|.|          ..|
Mouse  1039 -------------------------IDDLLSSITY-SPKLERKTTECVTPMD----------SDN 1067

  Fly   696 SWHPSNSSPSSSLDIRAIDSLQHVVKCYNDHLRSLEQGRQPGRQADDEEQEEA--------TYQS 752
            .....||..                .|:|              .|.||:::..        :|..
Mouse  1068 EKGERNSKR----------------VCFN--------------VAGDEQEDSGHDTVSNRDSYSG 1102

  Fly   753 LPVAWQTQSEVSAGTQIPPSDNPADLSVLQLIDLDEIGRQAQRQRHHQPPAGFLDTKLMSSSPSA 817
            :| .|.:.. :.....:..||..::.:.:                     |.|  |.:.||..|:
Mouse  1103 IP-TWASMF-LKQHKALFCSDCNSNRNSI---------------------ASF--TSICSSQCSS 1142

  Fly   818 NYYRPTEEPEPLDLTQLNIEASVMCLVSKLKFFCGRCDSPAIRLRHPKAPIKREGFAVAPQQAPD 882
            .::  ::|.:..|  :|.|                     ::|:.|.|.............|...
Mouse  1143 YFH--SDEMDSGD--ELPI---------------------SVRISHDKQDKIHTCLEQLFSQIDS 1182

  Fly   883 VIAASAASGKQAPNLALDLKPQSVDSDGITTTGSVAVKKGNKFTDGLDLSMTTDWAAELRPSM-- 945
            :|           ||   ||.|:|..         |.::....|.|..|.   ::..|:...:
Mouse  1183 II-----------NL---LKGQAVIR---------AFEQTKYLTPGRGLQ---EFQQEMEAKLSC 1221

  Fly   946 -RKLRHAMDRLLKTARLMHSVQRLQQDMR-------CNRLQASIMY-------RRDVCFSQALTA 995
             |:||..:.:  ....|..|:|.|.|.:|       |..|.|.:.|       |||:.|.|:|.|
Mouse  1222 PRRLRLHLKQ--DPWNLPSSIQALAQSIRKHAEEVKCRILLALLEYSDSETQLRRDMVFCQSLVA 1284

  Fly   996 LVSSLMLRLWGS----------------ELDMGYLVMLRDLGPLAYFEGLLT-LYGNEADMWSDM 1043
            .|.:...:|..:                |....:|..:.:.|.|.:|:.||: ...:|..|..|.
Mouse  1285 TVCAFSEQLMAALNQMFDNSKENEMETCEASRRWLDQIANAGVLFHFQSLLSPNLKDEQAMLEDT 1349

  Fly  1044 CIAIEDLSAVSFQLVRAQGE--VAQTP-TPRITGSRQALEVQL--------PVPEHSLPGNGNSI 1097
            .:|:.||..|||....::.:  ||..| |.::.||||||:|..        .:|:....|.|
Mouse  1350 LVALFDLEKVSFFFKPSEEDPLVANVPLTYQVEGSRQALKVYFYMDSYHFEQLPQRLKNGGG--- 1411

  Fly  1098 SFKITPVFFNIGIN--EKASFAETLGQTKEQHRSNWDNYLRLSQYFGRYRKLGLGSVDTGESLQS 1160
             |||.||.|:..:.  |...:.:.:...:.|.:.|..:..::.||..:.|...|...::..:..|
Mouse  1412 -FKIHPVLFSQALESMEGYCYRDNISVEEFQAQINTASLEKVKQYNQKLRAFYLDKSNSPPNTTS 1475

  Fly  1161 LLGFMEQQLR------------------------ANV---SKNVKILHLAEDACRLMDGLRFTSC 1198
            ...::::.::                        .|.   :..|.:|.::.:.|..:.......|
Mouse  1476 KAAYIDKLMKPLNALDELYRLITSFIRSKRIAACVNTPCSASGVGLLSVSSELCDRLGACHIIMC 1540

  Fly  1199 KSAKDRTGMAVTLEQCRVLVREFQLPAKHVPYALSTMRSEGTRMDNVLKNIGKRKYAFNRTQVSF 1263
            .|...|..::|||||...|.|...||.:::..|:..||.:|.|:.|..||:|.|    :||..|
Mouse  1541 SSGVHRCTLSVTLEQTITLARSHGLPPRYIMQAMDVMRKQGARVQNTAKNLGVR----DRTPQS- 1600

  Fly  1264 LPAMYR-----PPVG 1273
            .|.:|:     ||||
Mouse  1601 APRLYKLCEPPPPVG 1615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42271	NP_996434.2	PH_INPP4A_INPP4B	1..145	CDD:270091	34/161 (21%)
		PH	21..123	CDD:278594	27/134 (20%)
		C2	201..318	CDD:301316	22/122 (18%)
Prex2	XP_006495504.1	RhoGEF	19..204	CDD:366202
		PH_Collybistin_ASEF	210..356	CDD:269931
		DEP_1_P-Rex	374..454	CDD:239886	3/9 (33%)
		DEP_2_P-Rex	466..558	CDD:239887	22/98 (22%)
		PDZ_signaling	587..662	CDD:238492	17/99 (17%)
		PDZ_signaling	669..736	CDD:238492	13/82 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810