DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42271 and inpp4b

DIOPT Version :9

Sequence 1:	NP_996434.2	Gene:	CG42271 / 2768892	FlyBaseID:	FBgn0259166	Length:	1280	Species:	Drosophila melanogaster
Sequence 2:	XP_012811045.2	Gene:	inpp4b / 100496097	XenbaseID:	XB-GENE-949180	Length:	927	Species:	Xenopus tropicalis

Alignment Length:	1109	Identity:	272/1109 - (24%)
Similarity:	430/1109 - (38%)	Gaps:	292/1109 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 EELSVPVPTEVVAPFE------------ELDLSELPICETALSCDTLPLDTLGRPPNPQVVCSLL 230
            ||.::.|...::.|.|            :..|:: |..|.||:|..|......|..|..|..|:.
Frog     5 EEQALDVAQNLIFPAEGGNPVGQDTARIQKTLAD-PKLEFALACKDLLTAARDRKLNTFVQISVA 68

  Fly   231 -PTAGEDCVWREHARTELQERTRTPQFLCTMRFQRSAGLSASTRLRFSVFDVRERMTLTAVP--- 291
             ||  |..:.| :|.||:.|.||.|.||..:.|.....:...|:::.:|:||:::...|.:|
Frog    69 HPT--EQSLTR-YANTEVVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSQETVLPEAS 130

  Fly   292 ---LGHAEVALG---------VIQDTSRLRLPLTSPRG--ECGFITLASWSPDAAVEPGQSGNGP 342
               ....:..||         |.....:|.|.|.:..|  :.|.|.:      :.|:.|:..||.
Frog   131 DPRTNSGKSLLGCSTFKVRDLVKSKEQQLSLNLKTLNGGKKIGNIEV------SLVKMGEIENGE 189

  Fly   343 PRSSTQLFDGSAGAGGATTSSRRAHRRTQSLPPKLGVRLFVPQQCGLQRVCSNPRLRTYRLHSSL 407
            ....|....|...:.....||..|.....:|               |..|..||..:.||..||.
Frog   190 ADQITTDVHGQKCSLVCECSSPEAISGKDNL---------------LNTVFRNPIYKFYRFPSSD 239

  Fly   408 GADISVQETLLESRLCCQLPQQLLSIWIQREKELLQEISGMGELSGEWRWRQMNLLEEHLRLLKD 472
            ...|.|:|.:.||.:...:|:||||::|:.:...::::..:|:||..|...:.|:|..:..::..
Frog   240 NKWICVREQMAESSMSFHIPKQLLSLYIKEDTRRIEQLKELGDLSPHWDNLRQNVLAHYEEMVSV 304

  Fly   473 YSQAKQNIQQLARDGVSFKRSSAKADESLEFLPVNLHVQRMWAQNDTLQRRGLLDVVTVGAFTRH 537
            |.::.:.:::  ..|.|||.|.:|.::||||:|:|||:|||...:..| :..|.||:|:||...|
Frog   305 YQESLEELEK--HTGSSFKSSCSKGEKSLEFVPINLHLQRMRVHSQKL-KDALYDVITIGAPAAH 366

  Fly   538 DPKGRKCGGLIKLLQESKSWKLEQSNACKVQAANDAVQATKQLRKEIVELMSQLLQLASRRSSMD 602
            . :|.|.|||.:||...::.|......|...:..:..:|     |||:..::.|..|.|
Frog   367 S-QGFKNGGLRRLLSRFEAEKKNTGYQCIYYSPENTAKA-----KEILSSINHLQPLIS------ 419

  Fly   603 MMPLCNQMVARTRTLLNLWEPSIVEEAVAFIERHRIIEEPENVLMEPMSPF-RKITQQLTALELK 666
                     :.|..|||..:....|.          :::....|.|....| |....||.:..|.
Frog   420 ---------SHTDLLLNSAKQHSAES----------LKDSLKTLSETTERFVRSFKDQLISNALL 465

  Fly   667 SPELEDFATPVVAPPDLWPRGQPPLMRSNSWHPSNSSPSSSLDIRAIDSLQHVVKCYNDHLRSLE 731
            :                               .|.:.||                |.|..|
Frog   466 A-------------------------------LSTARPS----------------CANKKL---- 479

  Fly   732 QGRQPGRQADDEEQEEATYQSLPVAWQTQSEVSAGTQIPPSDNPADLSVLQLIDLDEIGRQAQRQ 796
              ..|....:|.:.:|                        .||           |.:|.||
Frog   480 --TDPLSDTEDNKTDE------------------------QDN-----------LHQITRQ---- 503

  Fly   797 RHHQPPAGFLDTKLMSSSPSANYYRPTEEPEPLDLTQLNIEASVMCLVSKLKFFCGRCDSPAIRL 861
                           .|.|..:.|    :.|..|....|:..|:.|:::.
Frog   504 ---------------DSIPHLSDY----DEEEWDRVWANVGKSLNCIIAM--------------- 534

  Fly   862 RHPKAPIKREGFAVAPQQAPDVIAASAASGKQAPNLALDLKPQSVDSDGITTTG-SVAVKKGNKF 925
                                                          :|.:...| |....|....
Frog   535 ----------------------------------------------TDRLLEQGNSTRENKTECS 553

  Fly   926 TDGLDLSMTTDWAAELRPSMRKLRHAMDRLLKTARLMHSVQRLQQDMRCNRLQA-SIMYRRDVCF 989
            ::.:......||..:|.|.:..|:..::.::..|:...:.. :.|::.|...|. .:.:||||.|
Frog   554 SEDITSQQNGDWYEQLYPLIITLKDCVEEVVDRAKKSMTFV-VFQELACGLPQCLQLTFRRDVVF 617

  Fly   990 SQALTALVSSLMLRLWGSELDMGYLVMLRDLGPLAYFEGLLTLYGNEADMWSDMCIAIEDLSAVS 1054
            ||||:.|....:::|..|..:..:|..|..:|.|..:||||:.|..|..|..||.|.|.||..|:
Frog   618 SQALSGLTCGFIIKLHSSLHNEAFLHQLHTVGLLVQYEGLLSTYSEEVGMLEDMSIGISDLRHVA 682

  Fly  1055 FQLVRAQGEVAQTPTPRITGSRQ--ALEVQLP------VPEHSLPGNGNSISFKITPVFFNIGIN 1111
            |::..|..|   ...|.:||.|:  .:||:||      :|:....|.    ...:.|||||:|||
Frog   683 FKITEATSE---DFLPLVTGRRERFMVEVKLPTKMFELLPQEIKDGK----LLCVHPVFFNVGIN 740

  Fly  1112 EKASFAETLGQTKEQHRSNWDNYLRLSQYFGRYRKLGLGSVDTG--------ESLQSLLGFMEQQ 1168
            |:.:.||..|.|..|...|.:|...|.:|:    ::.:..|.:.        ..::.||..:.|.
Frog   741 EQQTIAERFGDTSLQESINQENVEHLEEYY----RMCIEKVPSACPQLLQEQSDVKELLENLHQN 801

  Fly  1169 LRANVSKNVKILHLAEDACRLMDGLRFTSCKSAKDRTGMAVTLEQCRVLVREFQLPAKHVPYALS 1233
            .:|...|||:|:.||...||.|:|:|||.||||||||.|:||||||::|..|..|.......||.
Frog   802 TQAKKRKNVEIMWLAATICRKMNGVRFTCCKSAKDRTSMSVTLEQCQILRDEHDLHKDFFVRALD 866

  Fly  1234 TMRS 1237
            .|||
Frog   867 CMRS 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42271	NP_996434.2	PH_INPP4A_INPP4B	1..145	CDD:270091
		PH	21..123	CDD:278594
		C2	201..318	CDD:301316	37/134 (28%)
inpp4b	XP_012811045.2	C2A_Copine	39..173	CDD:176013	37/136 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	391	1.000	Domainoid score	I780
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	391	1.000	Inparanoid score	I1945
OMA	1	1.010	-	-		QHG46978
OrthoDB	1	1.010	-	-		D129165at2759
OrthoFinder	1	1.000	-	-		FOG0002887
OrthoInspector	1	1.000	-	-		otm47442
Panther	1	1.100	-	-	LDO	PTHR12187
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1907
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080