DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33253 and STOML2

DIOPT Version :9

Sequence 1:	NP_001259699.1	Gene:	CG33253 / 2768889	FlyBaseID:	FBgn0030992	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_038470.1	Gene:	STOML2 / 30968	HGNCID:	14559	Length:	356	Species:	Homo sapiens

Alignment Length:	272	Identity:	74/272 - (27%)
Similarity:	134/272 - (49%)	Gaps:	53/272 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 PISVFICFKVVSEYERAVIFRMGRLRSGGARGPGVFFVLPCVDDY-YPVDLRTVSFDVPPQEVLS 149
            |.:..:.|  |.:.|..|:.||||...  ...||:..::|.:|.. |...|:.:..:||.|..::
Human    33 PRNTVVLF--VPQQEAWVVERMGRFHR--ILEPGLNILIPVLDRIRYVQSLKEIVINVPEQSAVT 93

  Fly   150 KDSVTVTVDAVVYYRISDPLKAVIQVYNYSHSTSLLAATTLRNVLGTRNLSELLTERETISHTMQ 214
            .|:||:.:|.|:|.||.||.||...|.:..::.:.||.||:|:.||..:|.::..|||:::.::.
Human    94 LDNVTLQIDGVLYLRIMDPYKASYGVEDPEYAVTQLAQTTMRSELGKLSLDKVFRERESLNASIV 158

  Fly   215 MSLDEATDPWGVKVERVEIKDVSLPTALQRAMAAEAEAAREARAKVIAAEGEMKS---------- 269
            .::::|.|.||::..|.||||:.:|..::.:|..:.||.|..||.|:.:||..:|
Human   159 DAINQAADCWGIRCLRYEIKDIHVPPRVKESMQMQVEAERRKRATVLESEGTRESAINVAEGKKQ 223

  Fly   270 --------------SRALREASEIIS---ASPSALQL--------------------RYLQTLSS 297
                          ::|..|||.:::   |...|:::                    :|:...|.
Human   224 AQILASEAEKAEQINQAAGEASAVLAKAKAKAEAIRILAAALTQHNGDAAASLTVAEQYVSAFSK 288

  Fly   298 ISTEKNSTIIFP 309
            ::.:.| ||:.|
Human   289 LAKDSN-TILLP 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33253	NP_001259699.1	PHB	92..239	CDD:214581	50/147 (34%)
CG33253	NP_001259699.1	SPFH_SLP-4	112..319	CDD:259813	65/246 (26%)
STOML2	NP_038470.1	HflC	41..314	CDD:223407	72/262 (27%)
		SPFH_paraslipin	74..184	CDD:259811	38/109 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..356
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810