DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33253 and Nphs2

DIOPT Version :9

Sequence 1:	NP_001259699.1	Gene:	CG33253 / 2768889	FlyBaseID:	FBgn0030992	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_570841.3	Gene:	Nphs2 / 170672	RGDID:	620461	Length:	383	Species:	Rattus norvegicus

Alignment Length:	315	Identity:	133/315 - (42%)
Similarity:	197/315 - (62%)	Gaps:	30/315 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QHRARL-------HVGSPGSGGIQASSSTETFPLTPQHQSSQHAVHIPPPPSLPYQGLKTSENDD 65
            :|||..       .|.|||..|      ||...|....:              |.:|:|.|   .
  Rat    56 EHRAPAATVVNVDEVRSPGEEG------TEVVALLESER--------------PEEGIKPS---G 97

  Fly    66 MGCVEILATVVSVLIMVLTFPISVFICFKVVSEYERAVIFRMGRLRSGGARGPGVFFVLPCVDDY 130
            :|..|.|..:.|::.:::|||.|::.|.|||.||||.:|||:|.|..|.|:|||:||.|||:|.|
  Rat    98 LGACEWLLVLSSLIFIIVTFPFSIWFCIKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPCLDTY 162

  Fly   131 YPVDLRTVSFDVPPQEVLSKDSVTVTVDAVVYYRISDPLKAVIQVYNYSHSTSLLAATTLRNVLG 195
            :.||||..:.::|..||::||...:.:|||.|||:.:....:..:.:.|.:...|..||::.:|.
  Rat   163 HKVDLRLQTLEIPFHEVVTKDMFIMEIDAVCYYRMENASLLLSSLAHVSKAIQFLVQTTMKRLLA 227

  Fly   196 TRNLSELLTERETISHTMQMSLDEATDPWGVKVERVEIKDVSLPTALQRAMAAEAEAAREARAKV 260
            .|:|:|:|.||::|:..::::||..|..||:||||.|||||.||..||.::|.||||.|:|:.:|
  Rat   228 HRSLTEILLERKSIAQDVKVALDSVTCVWGIKVERTEIKDVRLPAGLQHSLAVEAEAQRQAKVRV 292

  Fly   261 IAAEGEMKSSRALREASEIISASPSALQLRYLQTLSSISTEKNSTIIFPLPMELL 315
            ||||||..:|.:||.|:||:|.:|:|:|||||.||.|:||:|.||::.|||.::|
  Rat   293 IAAEGEKAASESLRMAAEILSGTPAAVQLRYLHTLQSLSTDKPSTVVLPLPFDML 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33253	NP_001259699.1	PHB	92..239	CDD:214581	66/146 (45%)
CG33253	NP_001259699.1	SPFH_SLP-4	112..319	CDD:259813	97/204 (48%)
Nphs2	NP_570841.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73		4/16 (25%)
		SPFH_podocin	122..344	CDD:259809	108/221 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354434
Domainoid	1	1.000	58	1.000	Domainoid score	I10528
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062075at2759
OrthoFinder	1	1.000	-	-		FOG0000760
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750