DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33253 and Nphs2

DIOPT Version :9

Sequence 1:	NP_001259699.1	Gene:	CG33253 / 2768889	FlyBaseID:	FBgn0030992	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_569723.1	Gene:	Nphs2 / 170484	MGIID:	2157018	Length:	385	Species:	Mus musculus

Alignment Length:	302	Identity:	129/302 - (42%)
Similarity:	193/302 - (63%)	Gaps:	23/302 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VGSPGSGGIQASSSTETFPLTPQHQSSQHAVHIPPPPSLPYQGLKTSENDDMGCVEILATVVSVL 79
            |..||..|      ||...|....:              |.:|:|.|   .:|..|.|..:.|::
Mouse    72 VRGPGEEG------TEVVALLESER--------------PEEGIKPS---GLGACEWLLVLASLI 113

  Fly    80 IMVLTFPISVFICFKVVSEYERAVIFRMGRLRSGGARGPGVFFVLPCVDDYYPVDLRTVSFDVPP 144
            .:::|||.|::.|.|||.||||.:|||:|.|..|.|:|||:||.|||:|.|:.||||..:.::|.
Mouse   114 FIIMTFPFSIWFCIKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPCLDTYHKVDLRLQTLEIPF 178

  Fly   145 QEVLSKDSVTVTVDAVVYYRISDPLKAVIQVYNYSHSTSLLAATTLRNVLGTRNLSELLTERETI 209
            .||::||...:.:|||.|||:.:....:..:.:.|.:...|..||::.:|..|:|:|:|.||::|
Mouse   179 HEVVTKDMFIMEIDAVCYYRMENASLLLSSLAHVSKAIQFLVQTTMKRLLAHRSLTEILLERKSI 243

  Fly   210 SHTMQMSLDEATDPWGVKVERVEIKDVSLPTALQRAMAAEAEAAREARAKVIAAEGEMKSSRALR 274
            :..::::||..|..||:||||.|||||.||..||.::|.||||.|:|:.:|||||||..:|.:||
Mouse   244 AQDVKVALDAVTCIWGIKVERTEIKDVRLPAGLQHSLAVEAEAQRQAKVRVIAAEGEKAASESLR 308

  Fly   275 EASEIISASPSALQLRYLQTLSSISTEKNSTIIFPLPMELLT 316
            .|:||:|.:|:|:|||||.||.|:||||.:|::.|||.::|:
Mouse   309 MAAEILSGTPAAVQLRYLHTLQSLSTEKPATVVLPLPFDMLS 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33253	NP_001259699.1	PHB	92..239	CDD:214581	66/146 (45%)
CG33253	NP_001259699.1	SPFH_SLP-4	112..319	CDD:259813	97/205 (47%)
Nphs2	NP_569723.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		SPFH_podocin	124..346	CDD:259809	108/221 (49%)
		PHB	125..289	CDD:214581	75/163 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..385
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850729
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000760
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740