Protein Alignment CG33253 and PHB2

DIOPT Version :10

• Sequence 1: NP_001259699.1
• Gene: CG33253 / 2768889
• FlyBaseID: FBgn0030992
• Length: 414
• Species: Drosophila melanogaster
• Sequence 2: NP_001138303.1
• Gene: PHB2 / 11331
• HGNCID: 30306
• Length: 299
• Species: Homo sapiens
• Alignment Length: 245
• Identity: 62/245 - (25%)
• Similarity: 112/245 - (45%)
• Gaps: 43/245 - (17%)

  Fly    88 SVFICFKVVSEYERAVIF-RMGRLRSGGARGPGVFFVLPCVDDYYPV--DLRTVSFDVPPQEVL- 148
            |||    .|....||:.| |:|.::.......|:.|.:|...  ||:  |:|     ..|:::.
Human    39 SVF----TVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQ--YPIIYDIR-----ARPRKISS 92

  Fly   149 ---SKDSVTVTVDAVVYYR-ISDPLKAVIQVYNYSHSTSLLAA---TTLRNVLGTRNLSELLTER 206
               |||...|.:...|..| .:..|.::.|.....:...:|.:   ..|::|:...|.|:|:|:|
Human    93 PTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQR 157

  Fly   207 ETISHTMQMSLDEATDPWGVKVERVEIKDVSL----PTALQRAMAAEAEAAR----------EAR 257
            ..:|..::..|.|....:.:.::.|.|.::|.    ..|::....|:.||.|          |.|
Human   158 AQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQR 222

  Fly   258 AKVIAAEGEMKSSRALREASEIISASPSALQLRYLQTLSSIS----TEKN 303
            .|::.||||.::::.|.||   :|.:|..::||.::...:||    |.:|
Human   223 QKIVQAEGEAEAAKMLGEA---LSKNPGYIKLRKIRAAQNISKTIATSQN 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33253	NP_001259699.1	SPFH_SLP-4	112..319	CDD:259813	53/220 (24%)
PHB2	NP_001138303.1	Necessary for transcriptional repression. /evidence=ECO:0000269|PubMed:10359819	19..49		4/13 (31%)
		SPFH_prohibitin	40..235	CDD:259799	50/205 (24%)
		LC3-interaction region. /evidence=ECO:0000269|PubMed:28017329	121..124		1/2 (50%)
		Necessary for transcriptional repression. /evidence=ECO:0000269|PubMed:10359819	150..174		7/23 (30%)