DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdic4 and dync1i2a

DIOPT Version :9

Sequence 1:	NP_001368966.1	Gene:	Sdic4 / 2768886	FlyBaseID:	FBgn0053499	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	XP_017213212.2	Gene:	dync1i2a / 767729	ZFINID:	ZDB-GENE-060929-1086	Length:	626	Species:	Danio rerio

Alignment Length:	550	Identity:	291/550 - (52%)
Similarity:	378/550 - (68%)	Gaps:	63/550 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 YSTLSGGKKQPLNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQNL 77
            :|.|..|   ||.|::..:...:.||||.:.|||:|||.:          ...|.|:|:.
Zfish   119 HSELGRG---PLKLAMTKMTHVDFPPKEVVSYTKETQTPT----------MTEQKDEEDE----- 165

  Fly    78 GNGFTSKLPPGYLTHGLPTVKDVAPAITP-LEIKKETEVKKEV-----NELSEEQKQMIILSENF 136
                                ::..||..| .|.:||...:|:|     :||:||:|..|:.||.|
Zfish   166 --------------------EEETPAAQPEAETEKEKPEEKQVEEALPHELTEEEKLQILHSEEF 210

  Fly   137 QRFVVRAGRVIERALSENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDW 201
            ..|...:.|::||||||:||::.||.|....|:..:.::..:|||||.|.|:||||.|.:|.:||
Zfish   211 MDFFDHSTRIVERALSEHVDVFFDYSGRDMEEKEGEMQAGTKLSLNRKFVDDRWSKQRVVTCLDW 275

  Fly   202 STHFPELVVGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGT 266
            |..:|||:|.||:||||:|:|||||.:|||.|:||:|||.||||||||||..||||:|||::|||
Zfish   276 SPQYPELLVASYNNNEEAPHEPDGVALVWNMKYKKATPEYVFHCQSAVMSAAFAKFHPNLVVGGT 340

  Fly   267 YSGQIVLWDNRVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQ 331
            |||||||||||..:|||:||||||||||||||||:.:||||||||:||||:|||:||||||||||
Zfish   341 YSGQIVLWDNRSNRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKMCSWSLDMLSQ 405

  Fly   332 PQDTLELQQRQSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGI 396
            |||::||..:|||::|:|||:||..::|:.|:|||||.||:|||||.|:|::|::|.|.||||||
Zfish   406 PQDSMELVFKQSKSVAVTSMSFPLGDVNNFVVGSEDGSVYTASRHGSRAGISEMFEGHHGPITGI 470

  Fly   397 STHYNQLSPDFGHLFLTSS----IKIWSLKLPISSCQFSVVSGINSNKPLYSFEDNSDYMMDVAW 457
            ..|......||.|||||:|    :|:||.|               :|||||||||||||:.||.|
Zfish   471 HCHTAAGPVDFSHLFLTASFDWTVKLWSNK---------------NNKPLYSFEDNSDYVYDVMW 520

  Fly   458 SPVHPALFAAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVY 522
            |||||||||.|||.||:||||||.||||||||:.|.|:|||||:.|:.||..:.:||..|::::|
Zfish   521 SPVHPALFACVDGLGRVDLWNLNNDTEVPTASVAVDGSPALNRLRWSQSGREIAVGDSEGQIHIY 585

  Fly   523 DVAENLAQPSRDEWSRFNTHLSEIKMNQSD 552
            ||.|.:|.|..|||:||...|.||..|:.|
Zfish   586 DVGEQIAVPRNDEWTRFVRTLVEINENRDD 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdic4	NP_001368966.1	Dynein_IC2	23..51	CDD:402922	12/27 (44%)
		WD40	196..523	CDD:421866	213/330 (65%)
		WD40 repeat	196..245	CDD:293791	31/48 (65%)
		WD40 repeat	251..289	CDD:293791	28/37 (76%)
		WD40 repeat	298..337	CDD:293791	31/38 (82%)
		WD40 repeat	349..446	CDD:293791	49/100 (49%)
		WD40 repeat	452..490	CDD:293791	30/37 (81%)
		WD40 repeat	498..524	CDD:293791	10/25 (40%)
dync1i2a	XP_017213212.2	Dynein_IC2	126..154	CDD:402922	12/27 (44%)
		WD40	269..586	CDD:421866	213/331 (64%)
		WD40 repeat	270..317	CDD:293791	29/46 (63%)
		WD40 repeat	324..363	CDD:293791	29/38 (76%)
		WD40 repeat	372..415	CDD:293791	33/42 (79%)
		WD40 repeat	423..461	CDD:293791	22/37 (59%)
		WD40 repeat	470..509	CDD:293791	20/53 (38%)
		WD40 repeat	515..542	CDD:293791	20/26 (77%)
		WD40 repeat	561..587	CDD:293791	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573336
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	624	1.000	Inparanoid score	I842
OMA	1	1.010	-	-		QHG54336
OrthoDB	1	1.010	-	-		D1453532at2759
OrthoFinder	1	1.000	-	-		FOG0001314
OrthoInspector	1	1.000	-	-		mtm6471
orthoMCL	1	0.900	-	-		OOG6_101571
Panther	1	1.100	-	-	O	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X812
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.910