DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sdic4 and dnai2a

DIOPT Version :9

Sequence 1:	NP_001368966.1	Gene:	Sdic4 / 2768886	FlyBaseID:	FBgn0053499	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	XP_017213955.1	Gene:	dnai2a / 563648	ZFINID:	ZDB-GENE-070410-46	Length:	567	Species:	Danio rerio

Alignment Length:	465	Identity:	119/465 - (25%)
Similarity:	202/465 - (43%)	Gaps:	64/465 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 LTHGLPTVKDVAPAITPLEIKKETEVKKEVNELSEEQKQMIILSENFQRFVVRAGRVIE---RAL 151
            ::||:..|:...|         || :....:||:...::.:...|::|:.|:....|:|   :.:
Zfish    78 VSHGMNHVEGGWP---------ET-ISANNDELTLRYRKKVQKDESYQQTVIETVSVMENYKQKV 132

  Fly   152 SENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDW---STHFPELVVG-S 212
            .|...:|..     |:.........|...:..|..|.:..| |..||:.|   ..|  :|.|. |
Zfish   133 FEKSQVYFK-----DNRVVVKREDMASARIINVLRDPKKEK-RAATSLSWHPVDNH--KLAVAYS 189

  Fly   213 YHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNR 277
            ....:..|........:||.:..|. ||......|.::...:...|.::::||:|:|||..||.|
Zfish   190 CVEFQRGPKNMSSDSYIWNIENNKQ-PEMTLKSVSPLVCLEYNLKNISILIGGSYNGQIGYWDTR 253

  Fly   278 VQKRTPIQRTPLSAAAHTH--PVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQ 340
            ...: |:|   :||..|:|  |||.:..:.|:......|.|:||::..|.:..:|:|...|.|..
Zfish   254 SGSQ-PVQ---ISAIEHSHKDPVYKVIWLQTKIGTEAFSASTDGQVLFWDIRNMSEPTKQLILDP 314

  Fly   341 RQSK----AIAITSMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEV---YERHLGPITGIST 398
            .:||    |....||.|. |.:...::|:|.|.|...:|. |.:....:   |..||||:..:
Zfish   315 AKSKNLNNAFGAFSMEFD-NTMPKFLVGTEQGLVVLCNRK-LETTDEPIVCTYSGHLGPVYAV-- 375

  Fly   399 HYNQLSPDFGHLFLTS---SIKIWSLKLPISSCQFSVVSGINSNKPLYSFEDNSDYMMDVAWSPV 460
               |.:|.|...|||.   :.:|||..:.:||              :.|.:.::.::||..||||
Zfish   376 ---QRNPFFPKYFLTVADWTARIWSEDIRLSS--------------IMSTKYHTSHLMDGCWSPV 423

  Fly   461 HPALFAAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVA 525
            .||:|..|...|.||:|::....:.|..|:.|......:......|.| :|.|.:.|.:.:..::
Zfish   424 RPAVFFTVKMDGTLDVWDILLKQKDPVLSLKVCDETLYSIRVKNDSPL-MCCGSQLGTVTLLKMS 487

  Fly   526 ENLAQPSRDE 535
            .||.....:|
Zfish   488 PNLCTLQSNE 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdic4	NP_001368966.1	Dynein_IC2	23..51	CDD:402922
		WD40	196..523	CDD:421866	95/342 (28%)
		WD40 repeat	196..245	CDD:293791	13/52 (25%)
		WD40 repeat	251..289	CDD:293791	12/37 (32%)
		WD40 repeat	298..337	CDD:293791	10/38 (26%)
		WD40 repeat	349..446	CDD:293791	27/102 (26%)
		WD40 repeat	452..490	CDD:293791	15/37 (41%)
		WD40 repeat	498..524	CDD:293791	5/25 (20%)
dnai2a	XP_017213955.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910