DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdic4 and dync1i2

DIOPT Version :9

Sequence 1:	NP_001368966.1	Gene:	Sdic4 / 2768886	FlyBaseID:	FBgn0053499	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	XP_012825730.1	Gene:	dync1i2 / 407935	XenbaseID:	XB-GENE-960812	Length:	655	Species:	Xenopus tropicalis

Alignment Length:	539	Identity:	287/539 - (53%)
Similarity:	377/539 - (69%)	Gaps:	57/539 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PLNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQNLGNGFTSKLPP 87
            |:.|.:..|...:..|:||:.|||:|||        .:||.|.:||::|.
Frog   154 PIKLGMSKVTQVDFAPRETVSYTKETQT--------PILAQDNEGDEDEE--------------- 195

  Fly    88 GYLTHGLPTVKDVAPAITPLE-----IKKETEVKKEVNELSEEQKQMIILSENFQRFVVRAGRVI 147
                      :.|||....::     .|||.:.:...:||:||:||.||.||.|..|...:.|::
Frog   196 ----------ETVAPKAVAIQEEDKPEKKEEKTEAPPHELTEEEKQQIIHSEEFVSFFDHSTRIV 250

  Fly   148 ERALSENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGS 212
            ||||||:|:|:.||.|....|:..:.::.|:||.||.|:||||||:|.::.:|||:.:|||:|.|
Frog   251 ERALSEHVNIFFDYSGRDLEEKEGEIQAGAKLSFNRQFFDERWSKHRVVSCLDWSSQYPELLVAS 315

  Fly   213 YHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNR 277
            |:|||::|:|||||.:|||.|:||.|||.||||||||||..||:|:|||::||||||||||||||
Frog   316 YNNNEDAPHEPDGVALVWNMKYKKMTPEYVFHCQSAVMSAAFARFHPNLVVGGTYSGQIVLWDNR 380

  Fly   278 VQKRTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQ 342
            ..||||:||||||||||||||||:.:||||||||:||||:|||:|||||||||||||::||..:|
Frog   381 SNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSQPQDSMELVHKQ 445

  Fly   343 SKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDF 407
            |||:|:|.|:||..::|:.|:|||:|.||:|.|||.::|::|::|.|.||||||..|....:.||
Frog   446 SKAVAVTCMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHSAVGAVDF 510

  Fly   408 GHLFLTSS----IKIWSLKLPISSCQFSVVSGINSNKPLYSFEDNSDYMMDVAWSPVHPALFAAV 468
            .|||:|||    :|:|:.|               :|||||||||||||:.||.|||.||||||.|
Frog   511 SHLFVTSSFDWTVKLWTTK---------------NNKPLYSFEDNSDYVYDVMWSPTHPALFACV 560

  Fly   469 DGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSR 533
            ||.|||||||||.|||||||||.|.|.||||||.||.||..:.:|:..|::::|||.|.:|.|..
Frog   561 DGVGRLDLWNLNNDTEVPTASITVEGNPALNRVRWTHSGREIAVGNSEGEIFIYDVGEQIAVPRN 625

  Fly   534 DEWSRFNTHLSEIKMNQSD 552
            |||:||...|:||..|::|
Frog   626 DEWTRFARTLAEINANRAD 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdic4	NP_001368966.1	Dynein_IC2	23..51	CDD:402922	11/27 (41%)
		WD40	196..523	CDD:421866	209/330 (63%)
		WD40 repeat	196..245	CDD:293791	29/48 (60%)
		WD40 repeat	251..289	CDD:293791	28/37 (76%)
		WD40 repeat	298..337	CDD:293791	31/38 (82%)
		WD40 repeat	349..446	CDD:293791	44/100 (44%)
		WD40 repeat	452..490	CDD:293791	30/37 (81%)
		WD40 repeat	498..524	CDD:293791	11/25 (44%)
dync1i2	XP_012825730.1	Dynein_IC2	154..182	CDD:288403	12/35 (34%)
		WD40 repeat	299..346	CDD:293791	27/46 (59%)
		WD40	372..>616	CDD:225201	162/258 (63%)
		WD40	397..>622	CDD:295369	143/239 (60%)
		WD40 repeat	451..498	CDD:293791	23/46 (50%)
		WD40 repeat	506..538	CDD:293791	17/46 (37%)
		WD40 repeat	544..582	CDD:293791	30/37 (81%)
		WD40 repeat	590..616	CDD:293791	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	376	1.000	Domainoid score	I857
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37921
Inparanoid	1	1.050	613	1.000	Inparanoid score	I890
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1453532at2759
OrthoFinder	1	1.000	-	-		FOG0001314
OrthoInspector	1	1.000	-	-		mtm9426
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X812
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060