DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdic4 and Dync2i1

DIOPT Version :9

Sequence 1:	NP_001368966.1	Gene:	Sdic4 / 2768886	FlyBaseID:	FBgn0053499	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	XP_006240750.1	Gene:	Dync2i1 / 314523	RGDID:	1306493	Length:	1037	Species:	Rattus norvegicus

Alignment Length:	632	Identity:	122/632 - (19%)
Similarity:	219/632 - (34%)	Gaps:	177/632 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TYSTLSGGKKQPLNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQN 76
            |:|.|.   ..|:|  .|::...|...|.    |||.....    |.|.:..|.|.:|.|:.
  Rat   485 TFSLLD---LPPVN--EYDMYIRNFGKKN----TKQAYVQY----NEDNVERDIQTEDIETR--- 533

  Fly    77 LGNGFTSKLPPGYLTHGLPTVKD-----VAPAI-TPLEIKKETEVKKEVNELSEEQKQMIILSEN 135
              ..:|.....|.:..|....||     |.|.| ||                            .
  Rat   534 --EVWTQHPGEGTVVSGGSEEKDFSDVTVVPKIDTP----------------------------R 568

  Fly   136 FQRFVVRAGRVIERALSENVDIYTDYIGGGDS-------EEANDERSHARLSLNRVFYDERWSKN 193
            ...|:..|.:|:...|.|      |.:..|.|       :..|...|.::|:.:..|...|  |.
  Rat   569 LSNFLRAACQVVAVLLEE------DRLAAGPSWIPRAQDKALNISDSSSQLNTSLPFLQSR--KV 625

  Fly   194 RCITSMDWSTHFPELVVGSYHNNEESPNEPD----GVVMVWNTKFKKSTPEDVFHCQSAVMSTCF 254
            .|:    .::......|.|.|:..|....|.    .::.||:. ::.|.|:.|..|:|.|...||
  Rat   626 SCL----HASRVQRQTVVSVHDLPEKAFAPSLDSRHLLCVWDI-WQPSGPQKVLICESKVTCCCF 685

  Fly   255 AKFNPNLILGGTYSGQIVLWDNR-------------------------------VQKRTPIQR-T 287
            :.....|:..||..|.:|:||.|                               |..|:|:|. .
  Rat   686 SPLKAFLLFAGTVHGSVVVWDLREDSRIHHYVRLSSCFWAFRTPTFSTDGILTSVNHRSPLQAIE 750

  Fly   288 PLSAAAHTHPVYCLQMVGTQN-----AHNVISISSDGKLCSW------SLDMLSQPQDTLELQQR 341
            |::.:|:....:.|....||.     :.::.|:...|.|..|      ..|:.....|...:...
  Rat   751 PVATSAYKKQSFVLSPFSTQEEMAGLSFHIASLDESGVLNVWVVVELPKADISGSMSDLGLIPGG 815

  Fly   342 QSKAIAIT----------------------SMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNE 384
            :.|.:..|                      |:.|..::.|..|:|::.|.:..::|...|.. .:
  Rat   816 RIKLVHSTVIQLGHSLSHKDGELWGSTQTLSVKFLPSDPNHFVVGTDMGLISHSTRQDWRVS-PK 879

  Fly   385 VYERHLGPITGISTHYNQLSPDFGHLFLT----SSIKIWSLKLPISSCQFSVVSGINSNKPLYSF 445
            |::.....:..|..:....||....:||.    .||::..|               .|.:|:..:
  Rat   880 VFKPQQHGVRPIKVNVIDFSPFEETVFLAGCSDGSIRLHQL---------------TSERPIMQW 929

  Fly   446 EDNSD--YMMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTA----------SIVVAGAPAL 498
            ::::.  .:..:.|||..||:|...|.:.|:.:|:|.::...|.|          ::.:.|.|..
  Rat   930 DNSTSGRSVTSLQWSPTRPAVFLVQDDASRIYVWDLLENDLGPVAQQPISPDKLVAMTIVGEPEK 994

  Fly   499 NRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDEWSRFNTHLSE 545
            ...|:    :.:.:...:|.:.:.::......|:.||.|:.:..|.:
  Rat   995 TSGSF----VALVLARTSGTVDIQNLKRRWTTPAADEHSQLHLLLQK 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdic4	NP_001368966.1	Dynein_IC2	23..51	CDD:402922	8/27 (30%)
		WD40	196..523	CDD:421866	75/411 (18%)
		WD40 repeat	196..245	CDD:293791	10/52 (19%)
		WD40 repeat	251..289	CDD:293791	14/69 (20%)
		WD40 repeat	298..337	CDD:293791	9/49 (18%)
		WD40 repeat	349..446	CDD:293791	20/122 (16%)
		WD40 repeat	452..490	CDD:293791	12/47 (26%)
		WD40 repeat	498..524	CDD:293791	2/25 (8%)
Dync2i1	XP_006240750.1	PRP38_assoc	87..166	CDD:289628
		WD40	608..1004	CDD:225201	80/422 (19%)
		WD40	677..965	CDD:295369	57/303 (19%)
		WD40 repeat	680..709	CDD:293791	10/28 (36%)
		WD40 repeat	714..757	CDD:293791	5/42 (12%)
		WD40 repeat	762..803	CDD:293791	8/40 (20%)
		WD40 repeat	844..885	CDD:293791	9/41 (22%)
		WD40 repeat	893..926	CDD:293791	8/47 (17%)
		WD40 repeat	938..963	CDD:293791	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910