DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdic4 and DYNC1I1

DIOPT Version :9

Sequence 1:	NP_001368966.1	Gene:	Sdic4 / 2768886	FlyBaseID:	FBgn0053499	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_004402.1	Gene:	DYNC1I1 / 1780	HGNCID:	2963	Length:	645	Species:	Homo sapiens

Alignment Length:	532	Identity:	281/532 - (52%)
Similarity:	363/532 - (68%)	Gaps:	50/532 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQNLGNGFTSKLPPGYL 90
            |.|..|...:..|:|.:.|:|:|||        .:....::.|:|:..:.....|..|:|.
Human   148 LGVSKVTQVDFLPREVVSYSKETQT--------PLATHQSEEDEEDEEMVESKVGQDSELE---- 200

  Fly    91 THGLPTVKDVAPAITPLEIKKETEVKK-EVNELSEEQKQMIILSENFQRFVVRAGRVIERALSEN 154
                             ...|:.|||: ...||:||:||.|:.||.|..|..|..|||||||:|:
Human   201 -----------------NQDKKQEVKEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAED 248

  Fly   155 VDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNNEES 219
            .||:.||.|....|:..|.::.|.||.||.||||.|||:|.:|.||||..:|||:|.||:|||::
Human   249 SDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYNNNEDA 313

  Fly   220 PNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPI 284
            |:|||||.:|||.||||:|||.||||||:|||.|||:|:|||::||||||||||||||..:|||:
Human   314 PHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPV 378

  Fly   285 QRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKAIAIT 349
            ||||||||||||||||:.:||||||||:|::|:|||:|||||||||.||:::||...:||.:|:|
Human   379 QRTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVT 443

  Fly   350 SMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTS 414
            .||||..::|:.|:|||:|.||:|.|||.::|:.||:|.|.||:|||:.|......||.|||:||
Human   444 GMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTS 508

  Fly   415 S----IKIWSLKLPISSCQFSVVSGINSNKPLYSFEDNSDYMMDVAWSPVHPALFAAVDGSGRLD 475
            |    :|:|:.|               .||||||||||:||:.||.||||||||||.|||.||||
Human   509 SFDWTVKLWTTK---------------HNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLD 558

  Fly   476 LWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDEWSRFN 540
            |||||.||||||||:.:.||.|||||.|..:|..|.:||..|:::||||.| ||.|..|||:||.
Human   559 LWNLNNDTEVPTASVAIEGASALNRVRWAQAGKEVAVGDSEGRIWVYDVGE-LAVPHNDEWTRFA 622

  Fly   541 THLSEIKMNQSD 552
            ..|.||:.|::|
Human   623 RTLVEIRANRAD 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdic4	NP_001368966.1	Dynein_IC2	23..51	CDD:402922	9/24 (38%)
		WD40	196..523	CDD:421866	205/330 (62%)
		WD40 repeat	196..245	CDD:293791	32/48 (67%)
		WD40 repeat	251..289	CDD:293791	28/37 (76%)
		WD40 repeat	298..337	CDD:293791	27/38 (71%)
		WD40 repeat	349..446	CDD:293791	45/100 (45%)
		WD40 repeat	452..490	CDD:293791	31/37 (84%)
		WD40 repeat	498..524	CDD:293791	12/25 (48%)
DYNC1I1	NP_004402.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		Interaction with DCTN1. /evidence=ECO:0000250	2..123
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..125
		Dynein_IC2	147..173	CDD:371592	10/32 (31%)
		Interaction with DYNLT1. /evidence=ECO:0000269\|PubMed:27502274	147..163		4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..221		16/80 (20%)
		WD40	283..606	CDD:392136	209/337 (62%)
		WD 1	285..334		31/48 (65%)
		WD40 repeat	291..337	CDD:293791	30/45 (67%)
		WD 2	338..378		30/39 (77%)
		WD40 repeat	346..385	CDD:293791	29/38 (76%)
		WD 3	387..428		31/40 (78%)
		WD40 repeat	393..434	CDD:293791	28/40 (70%)
		WD 4	437..477		21/39 (54%)
		WD40 repeat	442..481	CDD:293791	20/38 (53%)
		WD 5	482..527		22/59 (37%)
		WD40 repeat	488..529	CDD:293791	21/55 (38%)
		WD 6	530..570		32/39 (82%)
		WD40 repeat	535..573	CDD:293791	31/37 (84%)
		WD 7	576..615		21/39 (54%)
		WD40 repeat	581..607	CDD:293791	12/25 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140636
Domainoid	1	1.000	377	1.000	Domainoid score	I864
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	600	1.000	Inparanoid score	I957
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54336
OrthoDB	1	1.010	-	-		D1453532at2759
OrthoFinder	1	1.000	-	-		FOG0001314
OrthoInspector	1	1.000	-	-		mtm8531
orthoMCL	1	0.900	-	-		OOG6_101571
Panther	1	1.100	-	-	O	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X812
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.910