DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sdic2 and dync1i2a

DIOPT Version :10

Sequence 1:NP_996516.1 Gene:Sdic2 / 2768883 FlyBaseID:FBgn0053497 Length:543 Species:Drosophila melanogaster
Sequence 2:NP_001429003.1 Gene:dync1i2a / 767729 ZFINID:ZDB-GENE-060929-1086 Length:626 Species:Danio rerio


Alignment Length:535 Identity:295/535 - (55%)
Similarity:380/535 - (71%) Gaps:44/535 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 YSTLSGGKKQPLNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQNL 77
            :|.|..|   ||.|::..:...:.||||.:.|||:|||.:          ...|.|:|:.     
Zfish   119 HSELGRG---PLKLAMTKMTHVDFPPKEVVSYTKETQTPT----------MTEQKDEEDE----- 165

  Fly    78 GNGFTSKLPPGYLTHGLPTVKDVAPAITP-LEIKKETEVKKEV-----NELSEEQKQMIILSENF 136
                                ::..||..| .|.:||...:|:|     :||:||:|..|:.||.|
Zfish   166 --------------------EEETPAAQPEAETEKEKPEEKQVEEALPHELTEEEKLQILHSEEF 210

  Fly   137 QRFVVRAGRVIERALSENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDW 201
            ..|...:.|::||||||:||::.||.|....|:..:.::..:|||||.|.|:||||.|.:|.:||
Zfish   211 MDFFDHSTRIVERALSEHVDVFFDYSGRDMEEKEGEMQAGTKLSLNRKFVDDRWSKQRVVTCLDW 275

  Fly   202 STHFPELVVGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGT 266
            |..:|||:|.||:||||:|:|||||.:|||.|:||:|||.||||||||||..||||:|||::|||
Zfish   276 SPQYPELLVASYNNNEEAPHEPDGVALVWNMKYKKATPEYVFHCQSAVMSAAFAKFHPNLVVGGT 340

  Fly   267 YSGQIVLWDNRVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQ 331
            |||||||||||..:|||:||||||||||||||||:.:||||||||:||||:|||:||||||||||
Zfish   341 YSGQIVLWDNRSNRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKMCSWSLDMLSQ 405

  Fly   332 PQDTLELQQRQSKAIAITSMAFPANEINSVVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGI 396
            |||::||..:|||::|:|||:||..::|:.|:|||||.||:|||||.|:|::|::|.|.||||||
Zfish   406 PQDSMELVFKQSKSVAVTSMSFPLGDVNNFVVGSEDGSVYTASRHGSRAGISEMFEGHHGPITGI 470

  Fly   397 STHYNQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSG 461
            ..|......||.|||||:|.|||:||||.|:.|||||||||||||.||.||||||||||.|||.|
Zfish   471 HCHTAAGPVDFSHLFLTASFDWTVKLWSNKNNKPLYSFEDNSDYVYDVMWSPVHPALFACVDGLG 535

  Fly   462 RLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDEWS 526
            |:||||||.||||||||:.|.|:|||||:.|:.||..:.:||..|::::|||.|.:|.|..|||:
Zfish   536 RVDLWNLNNDTEVPTASVAVDGSPALNRLRWSQSGREIAVGDSEGQIHIYDVGEQIAVPRNDEWT 600

  Fly   527 RFNTHLSEIKMNQSD 541
            ||...|.||..|:.|
Zfish   601 RFVRTLVEINENRDD 615

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sdic2NP_996516.1 Dynein_IC2 21..51 CDD:463291 12/29 (41%)
WD40 196..512 CDD:475233 217/315 (69%)
WD40 repeat 196..245 CDD:293791 31/48 (65%)
WD40 repeat 251..289 CDD:293791 28/37 (76%)
WD40 repeat 298..337 CDD:293791 31/38 (82%)
WD40 repeat 349..435 CDD:293791 52/85 (61%)
WD40 repeat 441..479 CDD:293791 31/37 (84%)
WD40 repeat 487..513 CDD:293791 10/25 (40%)
dync1i2aNP_001429003.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 20..108
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 142..197 20/89 (22%)
WD 1. /evidence=ECO:0000255 265..314 30/48 (63%)
WD 2. /evidence=ECO:0000255 318..358 31/39 (79%)
WD 3. /evidence=ECO:0000255 367..408 34/40 (85%)
WD 4. /evidence=ECO:0000255 417..457 24/39 (62%)
WD 5. /evidence=ECO:0000255 462..507 27/44 (61%)
WD 6. /evidence=ECO:0000255 510..550 33/39 (85%)
WD 7. /evidence=ECO:0000255 556..595 17/38 (45%)
Blue background indicates that the domain is not in the aligned region.

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