DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdic2 and dnai4

DIOPT Version :9

Sequence 1:	NP_001285481.1	Gene:	Sdic2 / 2768883	FlyBaseID:	FBgn0053497	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001018595.1	Gene:	dnai4 / 553797	ZFINID:	ZDB-GENE-050522-322	Length:	778	Species:	Danio rerio

Alignment Length:	655	Identity:	147/655 - (22%)
Similarity:	250/655 - (38%)	Gaps:	184/655 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FLRSTYSTLSGGK-----------------KQPLNLSVYNVQATNIPPKETL----------VYT 45
            |.||.:.:.|..:                 ||.|:.|:.::|:....|||.|          .|.
Zfish   129 FTRSFFGSASASRISQTAESVTDETKDLLVKQDLSNSISDIQSHREEPKEQLRENILDSTANCYL 193

  Fly    46 KQTQTTSTGGGNGDVLAFDAQGDDEES-SLQNLGNGFTS--KLPPG---YLTHGLPTVKDVAPAI 104
            .:|:|...    .|:.|.....:.|:: :::...|.:|.  |...|   |:...:.|..| ||..
Zfish   194 SETETIWL----LDIPAVSVSLESEDAEAVKERNNAYTELCKNRQGNDKYVERSMQTFSD-APKT 253

  Fly   105 TPLEIKKETEVKKEV-----------NELSEEQKQMIILSENFQRFVVRA---GRVI-----ERA 150
            ..::....|.|.|.|           |.:|:.....::.||..:..:..:   |.::     .::
Zfish   254 KEVQCDSITMVDKAVMCTVWDMYDSFNNISDVSANTVVSSERHEATIPESSPEGHLVHPKRSNQS 318

  Fly   151 LSENVDIYTDYIGGGDS------------EEAN------------DERSHARLSLNRVFY----- 186
            ||....:.|  :.|..:            ||.:            |.....|:.|..||.
Zfish   319 LSVVSTVST--VSGSSTHIEKMACVLPLDEEPDLQLILQSDKLKQDLALMERVVLANVFQPKLAA 381

  Fly   187 ------------------DERW---SKN-------------------RCITSMDWSTHFPELVVG 211
                              :|.|   |||                   |.:|.|.|:...|:|:..
Zfish   382 YRQLPIIEDPDCVQMVMEEESWTEQSKNSHCPFLERLWDFSCELTMGRNVTCMVWNKKNPDLLAV 446

  Fly   212 SYHNNE-ESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWD 275
            .|...| ::||  .|:|..|:.| ..:.|:.||:|:|.|.:..|:..|.|.:..|.|.|.|.:::
Zfish   447 GYGQVEFKNPN--SGLVCCWSLK-NPTWPDRVFYCESGVTALDFSASNANQLAVGMYDGTIAIYN 508

  Fly   276 NRVQKRTPIQRTPLSAAAHTHPVYCLQMV------GTQNAHNVISISSDGKLCSW-------SLD 327
            .:..::|||..:...|..||.||:.|..:      .......::|:||||::..|       .:|
Zfish   509 VQTSEQTPITDSSDCANLHTSPVWQLTWIDHEDGLAADKGEILVSVSSDGRISKWIHYKSMECVD 573

  Fly   328 MLSQPQDTLELQQRQSKAIAITSMAFPANEINSVVMGSEDGYVYSASRHGLRSGVNE----VYER 388
            ::......|:.:|..|.........|..|:....::|:|:|:::..|     |..||    .|:.
Zfish   574 LMKLKIHDLQWKQHISSLTPGMCFDFHPNDSKIYLVGTEEGHIHKCS-----SSYNEQYLDSYKA 633

  Fly   389 HLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPAL 453
            |..|:..::     .||....:||:.|.||||:||......|:..|......|.|:.|||....:
Zfish   634 HKRPVYKVT-----WSPFCSDVFLSCSSDWTIQLWRQDLQIPVMGFTSGQRVVFDIMWSPHCATV 693

  Fly   454 FAAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLH------------VCIGDEAG 506
            |.|| ..|::::|:|...:..||.            |:||..|::            |.:||..|
Zfish   694 FGAV-SEGKVEIWDLRVSSLDPTL------------VNWTSPGVNPTALLFSPETDCVLVGDSEG 745

  Fly   507 KLYVY 511
            ::.||
Zfish   746 QVTVY 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdic2	NP_001285481.1	Dynein_IC2	23..51	CDD:288403	9/37 (24%)
		NtpH	108..>178	CDD:225368	16/112 (14%)
		WD40	196..512	CDD:295369	93/346 (27%)
		WD40 repeat	196..245	CDD:293791	16/49 (33%)
		WD40	<224..523	CDD:225201	84/317 (26%)
		WD40 repeat	251..289	CDD:293791	10/37 (27%)
		WD40 repeat	298..337	CDD:293791	9/51 (18%)
		WD40 repeat	349..435	CDD:293791	24/89 (27%)
		WD40 repeat	441..479	CDD:293791	13/37 (35%)
		WD40 repeat	487..513	CDD:293791	10/37 (27%)
dnai4	NP_001018595.1	WD40 repeat	431..473	CDD:293791	13/44 (30%)
		WD40	<459..754	CDD:225201	84/316 (27%)
		WD 1. /evidence=ECO:0000255	477..517		11/39 (28%)
		WD40	479..751	CDD:295369	76/295 (26%)
		WD40 repeat	483..526	CDD:293791	11/42 (26%)
		WD 2. /evidence=ECO:0000255	526..573		11/46 (24%)
		WD40 repeat	531..576	CDD:293791	9/44 (20%)
		WD 3. /evidence=ECO:0000255	586..629		11/47 (23%)
		WD40 repeat	589..624	CDD:293791	8/39 (21%)
		WD 4. /evidence=ECO:0000255	633..673		14/44 (32%)
		WD40 repeat	638..675	CDD:293791	12/41 (29%)
		WD 5. /evidence=ECO:0000255	676..715		11/39 (28%)
		WD40 repeat	681..707	CDD:293791	10/26 (38%)
		WD 6. /evidence=ECO:0000255	721..760		7/30 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54336
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820