DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sdic2 and DYNC1I1

DIOPT Version :10

Sequence 1:NP_996516.1 Gene:Sdic2 / 2768883 FlyBaseID:FBgn0053497 Length:543 Species:Drosophila melanogaster
Sequence 2:NP_004402.1 Gene:DYNC1I1 / 1780 HGNCID:2963 Length:645 Species:Homo sapiens


Alignment Length:517 Identity:285/517 - (55%)
Similarity:365/517 - (70%) Gaps:31/517 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 LSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQNLGNGFTSKLPPGYL 90
            |.|..|...:..|:|.:.|:|:|||        .:....::.|:|:..:.....|..|:|.    
Human   148 LGVSKVTQVDFLPREVVSYSKETQT--------PLATHQSEEDEEDEEMVESKVGQDSELE---- 200

  Fly    91 THGLPTVKDVAPAITPLEIKKETEVKK-EVNELSEEQKQMIILSENFQRFVVRAGRVIERALSEN 154
                             ...|:.|||: ...||:||:||.|:.||.|..|..|..|||||||:|:
Human   201 -----------------NQDKKQEVKEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAED 248

  Fly   155 VDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNNEES 219
            .||:.||.|....|:..|.::.|.||.||.||||.|||:|.:|.||||..:|||:|.||:|||::
Human   249 SDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYNNNEDA 313

  Fly   220 PNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPI 284
            |:|||||.:|||.||||:|||.||||||:|||.|||:|:|||::||||||||||||||..:|||:
Human   314 PHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPV 378

  Fly   285 QRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKAIAIT 349
            ||||||||||||||||:.:||||||||:|::|:|||:|||||||||.||:::||...:||.:|:|
Human   379 QRTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVT 443

  Fly   350 SMAFPANEINSVVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTS 414
            .||||..::|:.|:|||:|.||:|.|||.::|:.||:|.|.||:|||:.|......||.|||:||
Human   444 GMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTS 508

  Fly   415 SIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTASI 479
            |.|||:|||:.|..|||||||||:|||.||.||||||||||.|||.|||||||||.||||||||:
Human   509 SFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASV 573

  Fly   480 VVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDEWSRFNTHLSEIKMNQSD 541
            .:.||.|||||.|..:|..|.:||..|:::||||.| ||.|..|||:||...|.||:.|::|
Human   574 AIEGASALNRVRWAQAGKEVAVGDSEGRIWVYDVGE-LAVPHNDEWTRFARTLVEIRANRAD 634

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sdic2NP_996516.1 Dynein_IC2 21..51 CDD:463291 9/24 (38%)
WD40 196..512 CDD:475233 209/315 (66%)
WD40 repeat 196..245 CDD:293791 32/48 (67%)
WD40 repeat 251..289 CDD:293791 28/37 (76%)
WD40 repeat 298..337 CDD:293791 27/38 (71%)
WD40 repeat 349..435 CDD:293791 48/85 (56%)
WD40 repeat 441..479 CDD:293791 32/37 (86%)
WD40 repeat 487..513 CDD:293791 12/25 (48%)
DYNC1I1NP_004402.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58
Interaction with DCTN1. /evidence=ECO:0000250 2..123
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 96..125
Dynein_IC2 143..173 CDD:463291 10/32 (31%)
Interaction with DYNLT1. /evidence=ECO:0000269|PubMed:27502274 147..163 4/14 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..221 16/80 (20%)
WD 1 285..334 31/48 (65%)
WD40 repeat 291..337 CDD:293791 30/45 (67%)
WD40 <318..607 CDD:441893 193/288 (67%)
WD 2 338..378 30/39 (77%)
WD40 repeat 346..385 CDD:293791 29/38 (76%)
WD 3 387..428 31/40 (78%)
WD40 repeat 393..434 CDD:293791 28/40 (70%)
WD 4 437..477 21/39 (54%)
WD40 repeat 442..481 CDD:293791 20/38 (53%)
WD 5 482..527 25/44 (57%)
WD40 repeat 488..529 CDD:293791 24/40 (60%)
WD 6 530..570 33/39 (85%)
WD40 repeat 535..573 CDD:293791 32/37 (86%)
WD 7 576..615 21/39 (54%)
WD40 repeat 581..607 CDD:293791 12/25 (48%)
Blue background indicates that the domain is not in the aligned region.

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