DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sdic2 and wdr-60

DIOPT Version :9

Sequence 1:	NP_001285481.1	Gene:	Sdic2 / 2768883	FlyBaseID:	FBgn0053497	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001367569.1	Gene:	wdr-60 / 175676	WormBaseID:	WBGene00016165	Length:	668	Species:	Caenorhabditis elegans

Alignment Length:	592	Identity:	105/592 - (17%)
Similarity:	211/592 - (35%)	Gaps:	131/592 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLAFDAQGDDEESSLQNLGNGFTSKLPPGYL 90
            |:..:::.|...||.|:. .|.:....|.....|...:....::|..:.:....|..:|| .|.:
Worm   103 LATSHMRRTEASPKPTIA-PKISNAQITVQSTIDNKPYSYHNEEERQTQEQRAFGRLNKL-RGLI 165

  Fly    91 T--------------------HGLPTVKDVAPAITPLEIKKETEVKKEVNELSEEQKQMIILSEN 135
            :                    :.||:.|..|...|..:...| ||:.|..| :||::.....||:
Worm   166 SIEVTKSQVFTDLSSNIFEPFNSLPSNKSHALTQTGKDCHTE-EVQTERGE-TEEKETQCPHSES 228

  Fly   136 ------------------FQRFVVRAGRVIERALSENVDIYTDYIGGGDSEEANDERSHARLSLN 182
                              .::|...|.:.|...|          |....|.|.::.|..:....:
Worm   229 TRIEDGIEKERTSTDRARLKKFFFAATQTIREIL----------ISEDKSAEEDETREKSISKFS 283

  Fly   183 RVFYDERW------SKNRCITSMDWSTHFPELVVGSYHNNEESPNEPDGVVMVWNTKF---KKST 238
            |.:...|.      ||:.||...:     .:.|:.:| ...||| .||.:......:|   |:..
Worm   284 RGYNPFRLCQVVTKSKSTCIRKGE-----SDSVLVAY-EIFESP-APDLINKSLIVEFFVHKRRP 341

  Fly   239 PEDVFHCQSAV----------------MSTCFAKFNPNLILGGTYSGQIVLW---DNRVQKRTP- 283
            |:.:|..:|.|                |...|..|  :|.:...:....:.|   :..:..|.|
Worm   342 PKRLFVVESIVSVMELSQSSQILYVCLMDGTFCAF--DLSITDAFFDDNLPWVDSETNIALRRPT 404

  Fly   284 ----IQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQ----- 339
                ...|.:|.|.   |:..:.:..:.....:.:|.:.|.:..|..:.:.:.:..|.|.
Worm   405 FDSSFLATTVSDAT---PLIGIALGKSSVGEEITTIDTAGTISYWIANRVEKNELRLLLTAVIRP 466

  Fly   340 ----QRQSKAIAITSMAFPANEINSVVMGSEDGYVYSASRHGLRSGVNEVY---ERHLGPITGIS 397
                :|.|.:.|:::.....|.:...: |::.|.:||..:......:.::|   :...|.:|.|:
Worm   467 HPVLKRHSTSFAVSAFCHVTNPLRFFI-GTDTGMLYSMYKSDTSQAIPKIYKTEKEKYGEVTVIA 530

  Fly   398 THYNQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSF--EDNSDYVMDVAWSPVHPALFAAVDGS 460
            .     :|....:.:....:.:|.::.......:.:.  .|.|..|..::||..:|:.|..:..|
Worm   531 A-----NPSDNTVLIVGFSNGSISVYRTTQASSIVNIPTADLSTRVTWISWSLTNPSGFYTIHNS 590

  Fly   461 GRLDLWNLN-----QDTEVPTASIVVAGAPALNRVSWTPSGL---HVCIGDEAGKLYVYDVAENL 517
            ..:..|:|.     :..:..|.|:.|..:.     :|.....   ::..|...|...|: |.|:.
Worm   591 NIITYWDLGFKLSPKSVDHRTDSVQVLASD-----TWLSENAKIGYMAFGLSNGDSEVH-VLEDP 649

  Fly   518 AQPSRDE 524
            |:.:::|
Worm   650 ARKNQNE 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdic2	NP_001285481.1	Dynein_IC2	23..51	CDD:288403	6/24 (25%)
		NtpH	108..>178	CDD:225368	17/87 (20%)
		WD40	196..512	CDD:295369	61/364 (17%)
		WD40 repeat	196..245	CDD:293791	12/51 (24%)
		WD40	<224..523	CDD:225201	57/347 (16%)
		WD40 repeat	251..289	CDD:293791	7/45 (16%)
		WD40 repeat	298..337	CDD:293791	3/38 (8%)
		WD40 repeat	349..435	CDD:293791	11/90 (12%)
		WD40 repeat	441..479	CDD:293791	9/42 (21%)
		WD40 repeat	487..513	CDD:293791	4/28 (14%)
wdr-60	NP_001367569.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810