DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rai1 and Dxo

DIOPT Version :9

Sequence 1:	NP_996492.1	Gene:	Rai1 / 2768882	FlyBaseID:	FBgn0030793	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_997662.1	Gene:	Dxo / 361799	RGDID:	1303267	Length:	397	Species:	Rattus norvegicus

Alignment Length:	366	Identity:	101/366 - (27%)
Similarity:	168/366 - (45%)	Gaps:	38/366 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 AMYNTPFPSISRPKCIGVCSINASREFVDDASCASYLAGQP--WPPLPFDLNGGIEDVIRKPVEN 81
            ::|:.|||...||..:|..|::|.|::..||....|.:..|  .|...|||..|..|..:...|.
  Rat    34 SLYSGPFPFYRRPSELGCFSLDAQRQYHGDARALRYYSPPPINGPGPDFDLRDGYPDRYQPRDEE 98

  Fly    82 GKRDLEIMLTYIKQHQKELLRQSSSDARNLRLDSDFVTLRGILRQIMCLQYDNR-SFRVKATLLN 145
            .:..|:.:|.::.:|:.:|      :.....|....||.||.|.:::...|:.: .:::.|:...
  Rat    99 VRERLDHLLRWVLEHRNQL------EGGPGWLAGATVTWRGHLTKLLTTPYERQEGWQLAASRFQ 157

  Fly   146 GNVYMCKEETPEQQLENANMSRAQRVMCSWGFKFEQYLTSAQAQGKPVTNVPVNEAEEFMGVYRT 210
            |.:|:.:.|||..:.:........|.:...|:|||||:.:.:..|.|..:..||....|..|.|:
  Rat   158 GTLYLSEVETPAARAQRLARPPLLRELMYMGYKFEQYMCADKPGGSPDPSGEVNTNVAFCSVLRS 222

  Fly   211 NLAGILMLYGAELDCVDSKEPVDFKDCRVLDSLKFVELKTSVFNMNPHQIRTFKSFKSANWWSQS 275
            .|....:|:..|:||::.:.|     |....|. :||||||....:|.|.|:|...|...||:||
  Rat   223 RLGNHPLLFSGEVDCLNPQAP-----CTQPPSC-YVELKTSKEMHSPGQWRSFYRHKLLKWWAQS 281

  Fly   276 FLVGITTLYVGLRDTKGM---LQRIDEIDVATLARN--KPWSASAMAWYLEQFLRNLKKLLVNIN 335
            ||.|:..:..|.|:.:|.   |:....:::....||  :.|:.|....:...||...:..:|. :
  Rat   282 FLPGVPYVVAGFRNPEGFVCSLKTFPTMEMFENVRNDQEGWNPSVCMNFCAAFLSFAQSTVVQ-D 345

  Fly   336 DPFAVVQVTFLNKHA-SYE--------VLRGPEHQILPNWY 367
            ||..|        |. |:|        |.|...:..||:||
  Rat   346 DPRLV--------HLFSWEPGGPVTVSVHRDAPYAFLPSWY 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rai1	NP_996492.1	RAI1	224..296	CDD:285815	27/74 (36%)
Dxo	NP_997662.1	Substrate binding. /evidence=ECO:0000250\|UniProtKB:O70348	131..133		0/1 (0%)
Dxo	NP_997662.1	RAI1	235..300	CDD:400814	26/70 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344268
Domainoid	1	1.000	79	1.000	Domainoid score	I8502
eggNOG	1	0.900	-	-		E1_KOG1982
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38061
Inparanoid	1	1.050	125	1.000	Inparanoid score	I4617
OMA	1	1.010	-	-		QHG53045
OrthoDB	1	1.010	-	-		D1034620at2759
OrthoFinder	1	1.000	-	-		FOG0004964
OrthoInspector	1	1.000	-	-		oto98227
orthoMCL	1	0.900	-	-		OOG6_104243
Panther	1	1.100	-	-	LDO	PTHR12395
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3502
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770