DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rai1 and Dxo

DIOPT Version :9

Sequence 1:	NP_996492.1	Gene:	Rai1 / 2768882	FlyBaseID:	FBgn0030793	Length:	375	Species:	Drosophila melanogaster
Sequence 2:	NP_001157242.1	Gene:	Dxo / 112403	MGIID:	1890444	Length:	397	Species:	Mus musculus

Alignment Length:	380	Identity:	103/380 - (27%)
Similarity:	171/380 - (45%)	Gaps:	48/380 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 HKL----------GAMYNTPFPSISRPKCIGVCSINASREFVDDASCASYLAGQP--WPPLPFDL 67
            |||          .::|:.|||...||..:|..|::|.|::..||....|.:..|  .|...|||
Mouse    20 HKLPRAVPLLRTQPSLYSGPFPFYRRPSELGCFSLDAQRQYHGDARALRYYSPPPINGPGPDFDL 84

  Fly    68 NGGIEDVIRKPVENGKRDLEIMLTYIKQHQKELLRQSSSDARNLRLDSDFVTLRGILRQIMCLQY 132
            ..|..|..:...|..:..|:.:|.::.:|:.:|      :.....|....||.||.|.:::...|
Mouse    85 RDGYPDRYQPRDEEVQERLDHLLRWVLEHRNQL------EGGPGWLAGATVTWRGHLTKLLTTPY 143

  Fly   133 DNR-SFRVKATLLNGNVYMCKEETPEQQLENANMSRAQRVMCSWGFKFEQYLTSAQAQGKPVTNV 196
            :.: .:::.|:...|.:|:.:.|||..:.:........|.:...|:|||||:.:.:..|.|..:.
Mouse   144 ERQEGWQLAASRFQGTLYLSEVETPAARAQRLARPPLLRELMYMGYKFEQYMCADKPGGSPDPSG 208

  Fly   197 PVNEAEEFMGVYRTNLAGILMLYGAELDCVDSKEPVDFKDCRVLDSLKFVELKTSVFNMNPHQIR 261
            .||....:..|.|:.|....:|:..|:||::.:.|     |....|. :||||||....:|.|.|
Mouse   209 EVNTNVAYCSVLRSRLGNHPLLFSGEVDCLNPQAP-----CTQPPSC-YVELKTSKEMHSPGQWR 267

  Fly   262 TFKSFKSANWWSQSFLVGITTLYVGLRDTKGM---LQRIDEIDVATLARN--KPWSASAMAWYLE 321
            :|...|...||:||||.|:..:..|.|:.:|.   |:....:::....||  :.|:.|....:..
Mouse   268 SFYRHKLLKWWAQSFLPGVPHVVAGFRNPEGFVCSLKTFPTMEMFENVRNDREGWNPSVCMNFCA 332

  Fly   322 QFLRNLKKLLVNINDPFAVVQVTFLNKHA-SYE--------VLRGPEHQILPNWY 367
            .||...:..:|. :||..|        |. |:|        |.|...:..||:||
Mouse   333 AFLSFAQSTVVQ-DDPRLV--------HLFSWEPGGPVTVSVHRDAPYAFLPSWY 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rai1	NP_996492.1	RAI1	224..296	CDD:285815	27/74 (36%)
Dxo	NP_001157242.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		3/9 (33%)
		Substrate binding. /evidence=ECO:0000269\|PubMed:23523372, ECO:0000269\|PubMed:28283058	131..133		0/1 (0%)
		RAI1	235..302	CDD:285815	26/72 (36%)
		Adenosine 3',5'-bisphosphate, inhibitor. /evidence=ECO:0000269\|PubMed:30180947	253..256		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840853
Domainoid	1	1.000	77	1.000	Domainoid score	I8894
eggNOG	1	0.900	-	-		E1_KOG1982
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38061
Inparanoid	1	1.050	122	1.000	Inparanoid score	I4730
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53045
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004964
OrthoInspector	1	1.000	-	-		oto94722
orthoMCL	1	0.900	-	-		OOG6_104243
Panther	1	1.100	-	-	LDO	PTHR12395
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R331
SonicParanoid	1	1.000	-	-		X3502
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790