DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AlkB and Alkbh3

DIOPT Version :9

Sequence 1:	NP_001334682.1	Gene:	AlkB / 2768870	FlyBaseID:	FBgn0065035	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	NP_001014202.1	Gene:	Alkbh3 / 362169	RGDID:	1359731	Length:	295	Species:	Rattus norvegicus

Alignment Length:	244	Identity:	51/244 - (20%)
Similarity:	79/244 - (32%)	Gaps:	67/244 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 PNIVNLNERLFDESVRSDW----------WKQLNLCSDGVEFQRIKSAMRWTTFGYHHNWDTKIY 157
            |..|:|.|        :||          |||.....:.:.:.:.:....:....|       .|
  Rat    94 PGFVDLKE--------ADWILERLCQDVPWKQRMGIREDITYPQPRLTAWYGELPY-------TY 143

  Fly   158 DEEMQSPFPEDLSSLCGLFAQALGYADFKPEAAIVNYY-PVGSTLSGHTDHSEPNKSAPLF-SFS 220
            ......|.|..|..|..|.::..........:.:.|:| ....::..|:|......|.|:. |.|
  Rat   144 SRVTMEPNPHWLPVLWTLKSRIEENTGHTFNSLLCNFYRDEKDSVDWHSDDEPSLGSCPVIASLS 208

  Fly   221 FGQTAIFLIGGRSLEEKPTAIYLQSGDVMIMSGESRLCYHAVPRIIKTQASATLSLIIEDVDNAD 285
            ||.|..|     .:.:||..  .::||           |..|.|:.......|| ||:|....||
  Rat   209 FGATRTF-----EMRKKPPP--EENGD-----------YTYVERVKIPLDHGTL-LIMEGATQAD 254

  Fly   286 IKTRTIDKDLFHDVGNPQFWEPFSRYMDDSRININIRQVL-----NPGD 329
            .:.|.                |...:..:.|:|:..|.|.     .|||
  Rat   255 WQHRV----------------PKEYHSRERRVNLTFRTVYPDPRGAPGD 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlkB	NP_001334682.1	None
Alkbh3	NP_001014202.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		2OG-FeII_Oxy	90..275	CDD:419693	46/230 (20%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q6NS38	141..143		1/8 (13%)
		Alpha-ketoglutarate binding. /evidence=ECO:0000250\|UniProtKB:Q96Q83	179..181		1/1 (100%)
		Alpha-ketoglutarate binding. /evidence=ECO:0000250\|UniProtKB:Q96Q83	269..275		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3145
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900