DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AlkB and ALKBH3

DIOPT Version :9

Sequence 1:	NP_001334682.1	Gene:	AlkB / 2768870	FlyBaseID:	FBgn0065035	Length:	332	Species:	Drosophila melanogaster
Sequence 2:	NP_631917.1	Gene:	ALKBH3 / 221120	HGNCID:	30141	Length:	286	Species:	Homo sapiens

Alignment Length:	214	Identity:	41/214 - (19%)
Similarity:	65/214 - (30%)	Gaps:	98/214 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 PNIVNLNERLFDESVRSDW----------WKQLNLCSDGVEFQRIKSAMRWTTFGYHHNWDTKIY 157
            |..|::.|        :||          |||.....:.:.:|:.:....:....|       .|
Human    94 PGFVDVKE--------ADWILEQLCQDVPWKQRTGIREDITYQQPRLTAWYGELPY-------TY 143

  Fly   158 DEEMQSPFPEDLSSLCGLFAQALGYADFKPEAAIVNYYPVGSTL-------SGHTDHS------- 208
            ......|.|                          :::||..||       :|||.:|
Human   144 SRITMEPNP--------------------------HWHPVLRTLKNRIEENTGHTFNSLLCNLYR 182

  Fly   209 ------------EPNKS-APLF-SFSFGQTAIFLIGGRSLEEKP-------------TAIYLQSG 246
                        ||:.. .|:. |.|||.|..|     .:.:||             ..|.|..|
Human   183 NEKDSVDWHSDDEPSLGRCPIIASLSFGATRTF-----EMRKKPPPEENGDYTYVERVKIPLDHG 242

  Fly   247 DVMIMSGESRLCY-HAVPR 264
            .::||.|.::..: |.||:
Human   243 TLLIMEGATQADWQHRVPK 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AlkB	NP_001334682.1	None
ALKBH3	NP_631917.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..45
		2OG-FeII_Oxy	90..275	CDD:328754	41/214 (19%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q6NS38	141..143		1/8 (13%)
		Alpha-ketoglutarate binding. /evidence=ECO:0000269\|PubMed:16858410, ECO:0007744\|PDB:2IUW	179..181		0/1 (0%)
		Alpha-ketoglutarate binding. /evidence=ECO:0000269\|PubMed:16858410, ECO:0007744\|PDB:2IUW	269..275
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3145
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900