DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr1 and PAPLN

DIOPT Version :9

Sequence 1:	NP_001286645.1	Gene:	dpr1 / 2768858	FlyBaseID:	FBgn0040726	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_001352835.1	Gene:	PAPLN / 89932	HGNCID:	19262	Length:	1278	Species:	Homo sapiens

Alignment Length:	280	Identity:	64/280 - (22%)
Similarity:	91/280 - (32%)	Gaps:	88/280 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PSNLLPYFDFDVPRNLTVTVGQTGFLHCRVERLGDKDVSWIRKRDLHILTAGGTTYTSDQRFQVL 112
            |:|.| ..|.:.||.:..:.||...:.||.|......:.|  :||       |.. .|..|.| |
Human  1039 PANRL-RLDQNQPRVVDASPGQRIRMTCRAEGFPPPAIEW--QRD-------GQP-VSSPRHQ-L 1091

  Fly   113 RPDGSANWTLQIKYPQPRDSGVYECQINTEPKMSLSYTFNVVE-----LKAEIFG-------PSD 165
            :||||    |.|......|.|.|.|           ..||..:     ::..:.|       |..
Human  1092 QPDGS----LVISRVAVEDGGFYTC-----------VAFNGQDRDQRWVQLRVLGELTISGLPPT 1141

  Fly   166 LMVKTGSDINLTCKIMQGPHELGNIFWYKGSEMLDGKGENEIDSSMARIRVEDDWTDGLTSRLKI 230
            :.|..|....|.| ::.|  |..||.|.:....:...|.        |:....|.|      |.|
Human  1142 VTVPEGDTARLLC-VVAG--ESVNIRWSRNGLPVQADGH--------RVHQSPDGT------LLI 1189

  Fly   231 KRAMPGDTGNYTC-----VPTVAKTSSVYVHVIIGEHPAAMQHNSSSN----------------- 273
            ......|.|:|||     ...|::::.|.|   :...|.|...:...:
Human  1190 YNLRARDEGSYTCSAYQGSQAVSRSTEVKV---VSPAPTAQPRDPGRDCVDQPELANCDLILQAQ 1251

  Fly   274 --SNSFYCGICCMLLSIVSC 291
              .|.:|...||     .||
Human  1252 LCGNEYYSSFCC-----ASC 1266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr1	NP_001286645.1	Ig	59..154	CDD:299845	27/94 (29%)
		IG_like	60..150	CDD:214653	25/89 (28%)
		IG_like	163..257	CDD:214653	24/98 (24%)
		Ig	174..244	CDD:143165	18/74 (24%)
PAPLN	NP_001352835.1	TSP1	29..80	CDD:214559
		ADAM_spacer1	183..298	CDD:310520
		TSP1	308..361	CDD:214559
		TSP1	369..424	CDD:214559
		TSP1	424..481	CDD:214559
		TSP1	488..539	CDD:214559
		Kunitz_BPTI	753..805	CDD:278443
		Papilin_u7	814..905	CDD:318767
		Ig	914..>978	CDD:325142
		I-set	1049..1119	CDD:254352	27/95 (28%)
		IG	1139..1219	CDD:214652	23/96 (24%)
		PLAC	1235..1267	CDD:312271	6/37 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900