DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr1 and Mxra8

DIOPT Version :9

Sequence 1:	NP_001286645.1	Gene:	dpr1 / 2768858	FlyBaseID:	FBgn0040726	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	NP_077225.4	Gene:	Mxra8 / 74761	MGIID:	1922011	Length:	442	Species:	Mus musculus

Alignment Length:	381	Identity:	80/381 - (20%)
Similarity:	124/381 - (32%)	Gaps:	149/381 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLNWLIGWLLLL---SMVLLRGYNAALAPTPPTTSTTTISPSNLLPYFDFDVPRNLTVTVGQTGF 72
            ||:.::.|.|||   |.||..|.:...|.:....|.:.:|                 :..|....
Mouse     3 LLSRVLLWKLLLLQSSAVLSSGPSGTAAASSSLVSESVVS-----------------LAAGTQAV 50

  Fly    73 LHCR-------VERLGDKD--VSW--------IRKRDLHILTAGGTTYTSDQRFQ--------VL 112
            |.|:       .:||.|:.  |.|        .|:|.:.:.:||      :||..        :|
Mouse    51 LRCQSPRMVWTQDRLHDRQRVVHWDLSGGPGSQRRRLVDMYSAG------EQRVYEPRDRDRLLL 109

  Fly   113 RP----DGSANWTLQIKYPQPRDSGVYEC-----------------QINTEPKMSLSYTFNVVEL 156
            .|    ||  |::|.|:.....|.|||.|                 ::..:|.:|.:|.....|:
Mouse   110 SPSAFHDG--NFSLLIRAVDRGDEGVYTCNLHHHYCHLDESLAVRLEVTEDPLLSRAYWDGEKEV 172

  Fly   157 KAEIFGPSDLMVKTGSDINLTCKIMQGPHELGNIFWYKGSEMLDGKGENEIDSSMARIRVEDDWT 221
                     |:|..|:...:||                                :.|..|   ||
Mouse   173 ---------LVVAHGAPALMTC--------------------------------INRAHV---WT 193

  Fly   222 D-GLTSRLKI---KRAMPGDTGNYTCVPTVAKTSSVYVHVIIGEH----PAAMQHNSSSNSNSFY 278
            | .|....::   .|.:||.:.:     ...:...:|..   ||.    |..::...|.|:|:|.
Mouse   194 DRHLEEAQQVVHWDRQLPGVSHD-----RADRLLDLYAS---GERRAYGPPFLRDRVSVNTNAFA 250

  Fly   279 CGICCMLL--------SIVSCCLQHFYETGCGYLHAAAAL---AKSAGLGPPKRAT 323
            .|...:.:        .|.||.|.|.|   || ||.....   .......||.||:
Mouse   251 RGDFSLRIDELERADEGIYSCHLHHHY---CG-LHERRVFHLQVTEPAFEPPARAS 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr1	NP_001286645.1	Ig	59..154	CDD:299845	29/140 (21%)
		IG_like	60..150	CDD:214653	28/135 (21%)
		IG_like	163..257	CDD:214653	15/97 (15%)
		Ig	174..244	CDD:143165	11/73 (15%)
Mxra8	NP_077225.4	V-set	46..156	CDD:284989	26/117 (22%)
		RGD 1. /evidence=ECO:0000305\|PubMed:18366072	128..130		0/1 (0%)
		V-set	171..291	CDD:284989	34/175 (19%)
		RGD 2. /evidence=ECO:0000305\|PubMed:18366072	251..253		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..319		4/7 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910