DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr1 and Hmcn2

DIOPT Version :9

Sequence 1:	NP_001286645.1	Gene:	dpr1 / 2768858	FlyBaseID:	FBgn0040726	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	XP_006498564.1	Gene:	Hmcn2 / 665700	MGIID:	2677838	Length:	5092	Species:	Mus musculus

Alignment Length:	312	Identity:	68/312 - (21%)
Similarity:	104/312 - (33%)	Gaps:	104/312 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GQTGFLHCRVERLGDKDVSWIRKRDLHILTAGGTTYTSDQRFQVLRPDGSANWTLQIKYPQPRDS 132
            |....|.|....:....::|  .::.:.||..|       .:.|     |.|.||.|..|.|:|:
Mouse   987 GVPASLPCIASGVPTPKITW--TKETNALTTSG-------HYSV-----SRNGTLVIVQPSPQDA 1037

  Fly   133 GVYEC---------------QINTEP--KMSLSYTFNVVELKAEIFGPSDLMVKTGSDINLTCKI 180
            |.|.|               .:||:|  ||:.|...:|         |..:.||.|.::.|.|:.
Mouse  1038 GAYVCTATNSVGFSSQEMWLSVNTKPMIKMNGSQAVDV---------PLRVTVKAGEEVTLDCEA 1093

  Fly   181 MQGPHELGNIFWYKGSEMLDGKGENEIDSSMARIRVEDDWTDGLTSRLKIKRAMPGDTGNYTCVP 245
            ...|..|  :.|.|.:..|              :.|.:.:....:..|::.:|..||.|.|.|..
Mouse  1094 QGSPTPL--LTWTKDANPL--------------LPVTNRYELLPSGSLRLAQAQVGDNGLYGCTA 1142

  Fly   246 T--VAKTSSVYV----------------HVIIGEH---PAAMQHNSSSNSNSFYCGICCMLLSIV 289
            :  ...||..||                .|:.||.   ....:.|.....|.|..|:..|
Mouse  1143 SNPAGATSRRYVLRVQVPPQVQPGPRVLKVLAGEALDLNCVAEGNPQPQLNWFKDGMALM----- 1202

  Fly   290 SCCLQHFYETGCGYLHAAAALAKSAGLGPPKRATLTTSETGISAAEVAAAAG 341
                   .|...|.:|.||               :.||:.|:...|.:.:||
Mouse  1203 -------GEGAQGSVHFAA---------------VKTSDAGLYRCEASNSAG 1232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr1	NP_001286645.1	Ig	59..154	CDD:299845	25/102 (25%)
		IG_like	60..150	CDD:214653	25/98 (26%)
		IG_like	163..257	CDD:214653	23/111 (21%)
		Ig	174..244	CDD:143165	14/69 (20%)
Hmcn2	XP_006498564.1	vWFA	38..196	CDD:238119
		Ig	445..511	CDD:319273
		IG	525..605	CDD:214652
		I-set	609..693	CDD:369462
		IG	707..783	CDD:214652
		IG_like	793..876	CDD:214653
		I-set	889..969	CDD:369462
		Ig	992..1058	CDD:386229	18/79 (23%)
		IG	1076..1157	CDD:214652	23/96 (24%)
		Ig	1161..1242	CDD:386229	19/99 (19%)
		Ig	1262..1336	CDD:386229
		I-set	1345..1429	CDD:369462
		I-set	1449..1523	CDD:369462
		IG	1553..1633	CDD:214652
		IGc2	1654..1716	CDD:197706
		Ig	1741..1819	CDD:386229
		Ig	1839..1903	CDD:386229
		I-set	1907..1986	CDD:369462
		Ig_3	1998..2073	CDD:372822
		Ig	2092..2179	CDD:386229
		Ig	2183..2273	CDD:386229
		Ig	2291..2367	CDD:386229
		IGc2	2389..2451	CDD:197706
		I-set	2476..2554	CDD:369462
		I-set	2558..2650	CDD:369462
		I-set	2668..2740	CDD:369462
		Ig	2782..2859	CDD:386229
		I-set	2876..2954	CDD:369462
		I-set	2966..3046	CDD:369462
		I-set	3050..3141	CDD:369462
		Ig	3145..3233	CDD:386229
		Ig	3256..3320	CDD:319273
		Ig	3347..3422	CDD:386229
		IG_like	3436..3511	CDD:214653
		IGc2	3530..3592	CDD:197706
		Ig	3614..3695	CDD:386229
		I-set	3699..3786	CDD:369462
		Ig	3789..3874	CDD:386229
		Ig	3900..3967	CDD:319273
		I-set	3974..4060	CDD:369462
		Ig	4064..4151	CDD:386229
		I-set	4155..4240	CDD:369462
		IGc2	4259..4321	CDD:197706
		I-set	4335..4421	CDD:369462
		G2F	4423..4605	CDD:369383
		FXa_inhibition	4664..4699	CDD:373209
		EGF_CA	4701..4744	CDD:311536
		EGF_CA	4746..4783	CDD:214542
		EGF_CA	4789..4829	CDD:214542
		EGF_CA	4896..4935	CDD:214542
		EGF_CA	4936..4974	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910