DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr1 and ROBO2

DIOPT Version :9

Sequence 1:	NP_001286645.1	Gene:	dpr1 / 2768858	FlyBaseID:	FBgn0040726	Length:	367	Species:	Drosophila melanogaster
Sequence 2:	XP_011532283.1	Gene:	ROBO2 / 6092	HGNCID:	10250	Length:	1597	Species:	Homo sapiens

Alignment Length:	281	Identity:	65/281 - (23%)
Similarity:	104/281 - (37%)	Gaps:	75/281 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LLLLSMVLLRGYNAALAPTPPTTSTTTISP--------SNLLPYFDF-----DVPRNLTVTVGQT 70
            ||.:.|:.|.|         ||.|..|.:|        .:.|...||     :.|.::.|:.|:.
Human    15 LLFVLMLFLSG---------PTLSKLTRTPWKGKPWKGGSRLRQEDFPPRIVEHPSDVIVSKGEP 70

  Fly    71 GFLHCRVERLGDKDVSWIRKRDLHILTAGGTTYTSD----QRFQVLRPDGSANWTLQI---KYPQ 128
            ..|:|:.|......:.|.:         .|....:|    :..::|.|.||. :.|:|   :..:
Human    71 TTLNCKAEGRPTPTIEWYK---------DGERVETDKDDPRSHRMLLPSGSL-FFLRIVHGRRSK 125

  Fly   129 PRDSGVYECQINTEPKMSLSYTFNVVELKAEI----------FGPSDLMVKTGSDINLTCKIMQG 183
            | |.|.|.|       ::.:|....|...|.:          ..|:|::|..|....|.|:..:|
Human   126 P-DEGSYVC-------VARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRG 182

  Fly   184 PHELGNIFWYKGSEMLDGKGENEIDSSMARIRVEDDWTDGLTSRLKIKRAMPGDTGNYTCVPT-- 246
             |....|:|.|....:|.|.|        ||.:..       .:|.|......|.|.||||.|
Human   183 -HPEPTIYWKKDKVRIDDKEE--------RISIRG-------GKLMISNTRKSDAGMYTCVGTNM 231

  Fly   247 VAKTSSVYVHVIIGEHPAAMQ 267
            |.:..|....:.:.|.|..::
Human   232 VGERDSDPAELTVFERPTFLR 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr1	NP_001286645.1	Ig	59..154	CDD:299845	21/101 (21%)
		IG_like	60..150	CDD:214653	20/96 (21%)
		IG_like	163..257	CDD:214653	27/95 (28%)
		Ig	174..244	CDD:143165	18/69 (26%)
ROBO2	XP_011532283.1	Ig1_Robo	53..152	CDD:143317	23/116 (20%)
		Ig	160..244	CDD:325142	27/99 (27%)
		Ig	265..333	CDD:325142
		Ig4_Robo	355..444	CDD:143203
		IG	451..532	CDD:214652
		FN3	549..642	CDD:238020
		FN3	673..758	CDD:238020
		FN3	766..859	CDD:238020
		PTN13_u3	<1374..>1431	CDD:318742
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910